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Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris.
Clin Chem Lab Med. 2011 Sep; 49(9):1547-54.CC

Abstract

BACKGROUND

Vaspin was a recently identified adipokine, playing a protective role in many metabolic diseases. The present study aimed to investigate the association between vaspin plasma level and stable angina pectoris (SAP) and unstable angina pectoris (UAP).

METHODS

A total of 88 patients with angiographically-proved coronary artery disease (CAD) (SAP 47, UAP 41) and 103 control subjects without cardiovascular diseases were enrolled in this study. Circulating vaspin, mRNA expression of vaspin in peripheral blood mononuclear cells (PBMC), clinical parameters, lipid profile and high-sensitivity C-reactive protein (hsCRP) were assayed. The severity of CAD was also assessed according to the number of vessels diseased.

RESULTS

There are significant differences in circulating vaspin levels and mRNA levels of PBMC between SAP and UAP groups (SAP 0.91±0.95 ng/mL and UAP 0.43±0.38 ng/mL, p<0.01 in circulating vaspin level; SAP 1.19±0.85 and UAP 0.82±0.56, p<0.05 in mRNA level of PBMC). An inverse correlation between the number of diseased vessels and plasma vaspin concentration was observed (r=-0.350, p<0.01) in the CAD group. Construction of receiver operating characteristic curves confirmed that vaspin plasma concentrations significantly differentiated CAD patients (area under the curve=0.684, p<0.001), as well as UAP (area under the curve=0.640, p<0.05).

CONCLUSION

Decreased vaspin plasma levels and mRNA levels in PBMC were observed in patients with UAP. Low vaspin concentrations correlate with CAD severity. The findings suggested that vaspin could serve as a novel biomarker of CAD as well as UAP.

Authors+Show Affiliations

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21913793

Citation

Li, Hai Ling, et al. "Vaspin Plasma Concentrations and mRNA Expressions in Patients With Stable and Unstable Angina Pectoris." Clinical Chemistry and Laboratory Medicine, vol. 49, no. 9, 2011, pp. 1547-54.
Li HL, Peng WH, Cui ST, et al. Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris. Clin Chem Lab Med. 2011;49(9):1547-54.
Li, H. L., Peng, W. H., Cui, S. T., Lei, H., Wei, Y. D., Li, W. M., & Xu, Y. W. (2011). Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris. Clinical Chemistry and Laboratory Medicine, 49(9), 1547-54. https://doi.org/10.1515/CCLM.2011.236
Li HL, et al. Vaspin Plasma Concentrations and mRNA Expressions in Patients With Stable and Unstable Angina Pectoris. Clin Chem Lab Med. 2011;49(9):1547-54. PubMed PMID: 21913793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaspin plasma concentrations and mRNA expressions in patients with stable and unstable angina pectoris. AU - Li,Hai Ling, AU - Peng,Wen Hui, AU - Cui,Shi Tao, AU - Lei,Hou, AU - Wei,Yi Dong, AU - Li,Wei Ming, AU - Xu,Ya Wei, PY - 2011/9/15/entrez PY - 2011/9/15/pubmed PY - 2012/1/21/medline SP - 1547 EP - 54 JF - Clinical chemistry and laboratory medicine JO - Clin Chem Lab Med VL - 49 IS - 9 N2 - BACKGROUND: Vaspin was a recently identified adipokine, playing a protective role in many metabolic diseases. The present study aimed to investigate the association between vaspin plasma level and stable angina pectoris (SAP) and unstable angina pectoris (UAP). METHODS: A total of 88 patients with angiographically-proved coronary artery disease (CAD) (SAP 47, UAP 41) and 103 control subjects without cardiovascular diseases were enrolled in this study. Circulating vaspin, mRNA expression of vaspin in peripheral blood mononuclear cells (PBMC), clinical parameters, lipid profile and high-sensitivity C-reactive protein (hsCRP) were assayed. The severity of CAD was also assessed according to the number of vessels diseased. RESULTS: There are significant differences in circulating vaspin levels and mRNA levels of PBMC between SAP and UAP groups (SAP 0.91±0.95 ng/mL and UAP 0.43±0.38 ng/mL, p<0.01 in circulating vaspin level; SAP 1.19±0.85 and UAP 0.82±0.56, p<0.05 in mRNA level of PBMC). An inverse correlation between the number of diseased vessels and plasma vaspin concentration was observed (r=-0.350, p<0.01) in the CAD group. Construction of receiver operating characteristic curves confirmed that vaspin plasma concentrations significantly differentiated CAD patients (area under the curve=0.684, p<0.001), as well as UAP (area under the curve=0.640, p<0.05). CONCLUSION: Decreased vaspin plasma levels and mRNA levels in PBMC were observed in patients with UAP. Low vaspin concentrations correlate with CAD severity. The findings suggested that vaspin could serve as a novel biomarker of CAD as well as UAP. SN - 1437-4331 UR - https://www.unboundmedicine.com/medline/citation/21913793/Vaspin_plasma_concentrations_and_mRNA_expressions_in_patients_with_stable_and_unstable_angina_pectoris_ L2 - https://www.degruyter.com/document/doi/10.1515/CCLM.2011.236 DB - PRIME DP - Unbound Medicine ER -