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Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy.
Diabet Med. 2012 Jun; 29(6):771-5.DM

Abstract

AIMS

Recently, an association between two polymorphisms (1181G>C and 245T>G) of the osteoprotegerin (OPG) gene and diabetic Charcot neuroarthropathy was suggested on the basis of studies of a limited number of samples derived from subjects from one geographical region (Italy). The aim of this study was to assess the presence of various osteoprotegerin gene polymorphisms in patients with diabetes and Charcot neuroarthropathy compared with subjects with diabetic neuropathy but no Charcot foot and healthy controls from another geographical region (Poland).

METHODS

DNA was isolated from 54 patients with Charcot neuroarthropathy, 35 subjects with diabetic neuropathy but no Charcot foot, and 95 healthy controls to evaluate OPG gene polymorphisms and their possible contribution to the development of Charcot neuroarthropathy.

RESULTS

Statistically significant differences between the group of subjects with neuropathy but no Charcot neuroarthropathy and the control group were found for 1217C>T, 950T>C and 245T>G polymorphisms, between the group of patients with Charcot neuroarthropathy and the control group for 1181G>C and 950T>C polymorphisms, and between the group of subjects with neuropathy but no Charcot neuroarthropathy and the group of patients with Charcot neuroarthropathy for 1217C>T and 245T>G polymorphisms.

CONCLUSION

We suggest that genetic factors, particularly OPG gene polymorphisms, may play a role in the development of diabetic Charcot neuroarthropathy.

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Authors+Show Affiliations

Korzon-Burakowska A
Department of Diabetology and Hypertension, Medical University of Gdańsk, Gdańsk, Poland. akorzon@wp.pl
Jakóbkiewicz-Banecka J
No affiliation info available
Fiedosiuk A
No affiliation info available
Petrova N
No affiliation info available
Koblik T
No affiliation info available
Gabig-Cimińska M
No affiliation info available
Edmonds M
No affiliation info available
Małecki MT
No affiliation info available
Węgrzyn G
No affiliation info available

MeSH

AdultArthropathy, NeurogenicDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NeuropathiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedOsteoprotegerinPolandPolymorphism, Single Nucleotide

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21913967

Citation

Korzon-Burakowska, A, et al. "Osteoprotegerin Gene Polymorphism in Diabetic Charcot Neuroarthropathy." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 29, no. 6, 2012, pp. 771-5.
Korzon-Burakowska A, Jakóbkiewicz-Banecka J, Fiedosiuk A, et al. Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy. Diabet Med. 2012;29(6):771-5.
Korzon-Burakowska, A., Jakóbkiewicz-Banecka, J., Fiedosiuk, A., Petrova, N., Koblik, T., Gabig-Cimińska, M., Edmonds, M., Małecki, M. T., & Węgrzyn, G. (2012). Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy. Diabetic Medicine : a Journal of the British Diabetic Association, 29(6), 771-5. https://doi.org/10.1111/j.1464-5491.2011.03442.x
Korzon-Burakowska A, et al. Osteoprotegerin Gene Polymorphism in Diabetic Charcot Neuroarthropathy. Diabet Med. 2012;29(6):771-5. PubMed PMID: 21913967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoprotegerin gene polymorphism in diabetic Charcot neuroarthropathy. AU - Korzon-Burakowska,A, AU - Jakóbkiewicz-Banecka,J, AU - Fiedosiuk,A, AU - Petrova,N, AU - Koblik,T, AU - Gabig-Cimińska,M, AU - Edmonds,M, AU - Małecki,M T, AU - Węgrzyn,G, PY - 2011/9/15/entrez PY - 2011/9/15/pubmed PY - 2012/8/29/medline SP - 771 EP - 5 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 29 IS - 6 N2 - AIMS: Recently, an association between two polymorphisms (1181G>C and 245T>G) of the osteoprotegerin (OPG) gene and diabetic Charcot neuroarthropathy was suggested on the basis of studies of a limited number of samples derived from subjects from one geographical region (Italy). The aim of this study was to assess the presence of various osteoprotegerin gene polymorphisms in patients with diabetes and Charcot neuroarthropathy compared with subjects with diabetic neuropathy but no Charcot foot and healthy controls from another geographical region (Poland). METHODS: DNA was isolated from 54 patients with Charcot neuroarthropathy, 35 subjects with diabetic neuropathy but no Charcot foot, and 95 healthy controls to evaluate OPG gene polymorphisms and their possible contribution to the development of Charcot neuroarthropathy. RESULTS: Statistically significant differences between the group of subjects with neuropathy but no Charcot neuroarthropathy and the control group were found for 1217C>T, 950T>C and 245T>G polymorphisms, between the group of patients with Charcot neuroarthropathy and the control group for 1181G>C and 950T>C polymorphisms, and between the group of subjects with neuropathy but no Charcot neuroarthropathy and the group of patients with Charcot neuroarthropathy for 1217C>T and 245T>G polymorphisms. CONCLUSION: We suggest that genetic factors, particularly OPG gene polymorphisms, may play a role in the development of diabetic Charcot neuroarthropathy. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/21913967/Osteoprotegerin_gene_polymorphism_in_diabetic_Charcot_neuroarthropathy_ L2 - https://doi.org/10.1111/j.1464-5491.2011.03442.x DB - PRIME DP - Unbound Medicine ER -