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Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats.
Asian Pac J Trop Med 2011; 4(8):619-23AP

Abstract

OBJECTIVE

To investigate hepatoprotective activity of ethanol extract of Melothria heterophylla Lour Cogn. (EEMH) against CCl(4)-induced hepatic damage in rats.

METHODS

β-sitosterol was isolated by column chromatography and characterized spectroscopically. Two different doses (200 and 400 mg/kg bw) of EEMH were administered orally in alternate days. The hepatoprotective activity was studied in liver by measuring biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein and total bilirubin. Lipid peroxidation product and different antioxidant enzyme activities were assessed in liver homogenate.

RESULTS

EEMH reduced all biochemical parameters and lipid peroxidation, as well as it increased the antioxidant enzyme activities in comparison with silymarin. The protective effect of the extract on CCl(4) induced damage was confirmed by histopathological examination of the liver.

CONCLUSIONS

This result strongly supports the protective effect of EEMH against acute liver injury, and may be attributed to its antioxidative activity.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. arijit_ncp@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21914539

Citation

Mondal, Arijit, et al. "Isolation and in Vivo Hepatoprotective Activity of Melothria Heterophylla (Lour.) Cogn. Against Chemically Induced Liver Injuries in Rats." Asian Pacific Journal of Tropical Medicine, vol. 4, no. 8, 2011, pp. 619-23.
Mondal A, Maity TK, Pal D, et al. Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats. Asian Pac J Trop Med. 2011;4(8):619-23.
Mondal, A., Maity, T. K., Pal, D., Sannigrahi, S., & Singh, J. (2011). Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats. Asian Pacific Journal of Tropical Medicine, 4(8), pp. 619-23. doi:10.1016/S1995-7645(11)60159-4.
Mondal A, et al. Isolation and in Vivo Hepatoprotective Activity of Melothria Heterophylla (Lour.) Cogn. Against Chemically Induced Liver Injuries in Rats. Asian Pac J Trop Med. 2011;4(8):619-23. PubMed PMID: 21914539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats. AU - Mondal,Arijit, AU - Maity,Tapan Kumar, AU - Pal,Dilipkumar, AU - Sannigrahi,Santanu, AU - Singh,Jagadish, PY - 2011/04/08/received PY - 2011/05/11/revised PY - 2011/06/15/accepted PY - 2011/9/15/entrez PY - 2011/9/15/pubmed PY - 2012/1/28/medline SP - 619 EP - 23 JF - Asian Pacific journal of tropical medicine JO - Asian Pac J Trop Med VL - 4 IS - 8 N2 - OBJECTIVE: To investigate hepatoprotective activity of ethanol extract of Melothria heterophylla Lour Cogn. (EEMH) against CCl(4)-induced hepatic damage in rats. METHODS: β-sitosterol was isolated by column chromatography and characterized spectroscopically. Two different doses (200 and 400 mg/kg bw) of EEMH were administered orally in alternate days. The hepatoprotective activity was studied in liver by measuring biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein and total bilirubin. Lipid peroxidation product and different antioxidant enzyme activities were assessed in liver homogenate. RESULTS: EEMH reduced all biochemical parameters and lipid peroxidation, as well as it increased the antioxidant enzyme activities in comparison with silymarin. The protective effect of the extract on CCl(4) induced damage was confirmed by histopathological examination of the liver. CONCLUSIONS: This result strongly supports the protective effect of EEMH against acute liver injury, and may be attributed to its antioxidative activity. SN - 2352-4146 UR - https://www.unboundmedicine.com/medline/citation/21914539/Isolation_and_in_vivo_hepatoprotective_activity_of_Melothria_heterophylla__Lour___Cogn__against_chemically_induced_liver_injuries_in_rats_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1995-7645(11)60159-4 DB - PRIME DP - Unbound Medicine ER -