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Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.
J Neuroimmunol. 2011 Oct 28; 239(1-2):87-90.JN

Abstract

LM1 is localized in human peripheral nerve myelin. Antibodies to ganglioside complexes (GSCs) have been reported in Guillain-Barré syndrome (GBS). We investigated IgG antibodies to LM1 and two GSCs (GM1 and LMI, or GD1b and LM1) in the sera of each 40 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and GBS, using ELISA. We detected anti-LM1 antibody in five with GBS and seven with CIDP; anti-GM1/LM1 antibody in three with GBS and one with CIDP; and anti-GD1b/LM1 antibody in two with CIDP. Antibodies to LM1 and LM1-containing GSCs may be among the targets for autoimmunity in GBS and CIDP.

Authors+Show Affiliations

Department of Neurology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21914557

Citation

Kuwahara, Motoi, et al. "Antibodies to LM1 and LM1-containing Ganglioside Complexes in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy." Journal of Neuroimmunology, vol. 239, no. 1-2, 2011, pp. 87-90.
Kuwahara M, Suzuki S, Takada K, et al. Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol. 2011;239(1-2):87-90.
Kuwahara, M., Suzuki, S., Takada, K., & Kusunoki, S. (2011). Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. Journal of Neuroimmunology, 239(1-2), 87-90. https://doi.org/10.1016/j.jneuroim.2011.08.016
Kuwahara M, et al. Antibodies to LM1 and LM1-containing Ganglioside Complexes in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy. J Neuroimmunol. 2011 Oct 28;239(1-2):87-90. PubMed PMID: 21914557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. AU - Kuwahara,Motoi, AU - Suzuki,Seiko, AU - Takada,Kazuo, AU - Kusunoki,Susumu, Y1 - 2011/09/13/ PY - 2011/06/14/received PY - 2011/08/22/revised PY - 2011/08/22/accepted PY - 2011/9/15/entrez PY - 2011/9/15/pubmed PY - 2011/12/20/medline SP - 87 EP - 90 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 239 IS - 1-2 N2 - LM1 is localized in human peripheral nerve myelin. Antibodies to ganglioside complexes (GSCs) have been reported in Guillain-Barré syndrome (GBS). We investigated IgG antibodies to LM1 and two GSCs (GM1 and LMI, or GD1b and LM1) in the sera of each 40 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and GBS, using ELISA. We detected anti-LM1 antibody in five with GBS and seven with CIDP; anti-GM1/LM1 antibody in three with GBS and one with CIDP; and anti-GD1b/LM1 antibody in two with CIDP. Antibodies to LM1 and LM1-containing GSCs may be among the targets for autoimmunity in GBS and CIDP. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/21914557/Antibodies_to_LM1_and_LM1_containing_ganglioside_complexes_in_Guillain_Barré_syndrome_and_chronic_inflammatory_demyelinating_polyneuropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(11)00233-5 DB - PRIME DP - Unbound Medicine ER -