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Iron, genes, and viruses: the porphyria cutanea tarda triple threat.
Cutis. 2011 Aug; 88(2):73-6.C

Abstract

Porphyria cutanea tarda (PCT) is a vesiculobulIous disorder often associated with estrogens, hepatitis C virus (HCV), alcoholism, hereditary hemochromatosis (HH), and human immunodeficiency virus. Hepcidin, a peptide hormone produced by the liver, has been associated with iron metabolism in 3 common precipitating factors for PCT: HCV, HH, and alcohol consumption. We present the case of a patient with erosions and noninflammatory bullae on his hands and forearms who received a diagnosis of PCT. On further examination, the patient was found to be positive for 3 precipitating factors: HCV, an HH gene mutation, and alcohol use. For patients with PCT, it is important to perform phenotypic screening for HCV and HH. Targeting hepcidin with replacement therapy to decrease iron may be a treatment of not only HCV, HH, and alcoholic cirrhosis, but also PCT.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21916273

Citation

Van Meter, Jonathan R., et al. "Iron, Genes, and Viruses: the Porphyria Cutanea Tarda Triple Threat." Cutis, vol. 88, no. 2, 2011, pp. 73-6.
Van Meter JR, Tierney KR, Pittelkow MR. Iron, genes, and viruses: the porphyria cutanea tarda triple threat. Cutis. 2011;88(2):73-6.
Van Meter, J. R., Tierney, K. R., & Pittelkow, M. R. (2011). Iron, genes, and viruses: the porphyria cutanea tarda triple threat. Cutis, 88(2), 73-6.
Van Meter JR, Tierney KR, Pittelkow MR. Iron, Genes, and Viruses: the Porphyria Cutanea Tarda Triple Threat. Cutis. 2011;88(2):73-6. PubMed PMID: 21916273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron, genes, and viruses: the porphyria cutanea tarda triple threat. AU - Van Meter,Jonathan R, AU - Tierney,Kelly R, AU - Pittelkow,Mark R, PY - 2011/9/16/entrez PY - 2011/9/16/pubmed PY - 2011/10/1/medline SP - 73 EP - 6 JF - Cutis JO - Cutis VL - 88 IS - 2 N2 - Porphyria cutanea tarda (PCT) is a vesiculobulIous disorder often associated with estrogens, hepatitis C virus (HCV), alcoholism, hereditary hemochromatosis (HH), and human immunodeficiency virus. Hepcidin, a peptide hormone produced by the liver, has been associated with iron metabolism in 3 common precipitating factors for PCT: HCV, HH, and alcohol consumption. We present the case of a patient with erosions and noninflammatory bullae on his hands and forearms who received a diagnosis of PCT. On further examination, the patient was found to be positive for 3 precipitating factors: HCV, an HH gene mutation, and alcohol use. For patients with PCT, it is important to perform phenotypic screening for HCV and HH. Targeting hepcidin with replacement therapy to decrease iron may be a treatment of not only HCV, HH, and alcoholic cirrhosis, but also PCT. SN - 0011-4162 UR - https://www.unboundmedicine.com/medline/citation/21916273/Iron_genes_and_viruses:_the_porphyria_cutanea_tarda_triple_threat_ L2 - http://www.diseaseinfosearch.org/result/5879 DB - PRIME DP - Unbound Medicine ER -