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Airway angiogenesis in stable and exacerbated chronic obstructive pulmonary disease.
Scand J Immunol. 2012 Jan; 75(1):109-14.SJ

Abstract

Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL-8 and TNF-α in patients with COPD during the stable phase and during acute exacerbation of the disease. We analysed induced sputum samples from 28 patients with COPD. Thirteen of these patients were followed up and second samples of sputum were obtained during acute exacerbation of the disease. The two control groups consisted of 12 healthy smokers and seven healthy non-smokers, all with normal lung function tests. Concentrations of VEGF, angiogenin, IL-8, TNF-α and bFGF were measured by cytometric bead array. In the induced sputum of patients with stable COPD, concentrations of VEGF (P < 0.001, P = 0.02), angiogenin (P < 0.0001, P < 0.0001), IL-8 (P < 0.0001, P = 0.0021) and TNF-α (P < 0.001, P = 0.03) were significantly elevated in comparison with healthy smokers and non-smokers. No additional elevation of angiogenic factors was demonstrated at the time of exacerbation. There was a significant negative correlation between FEV1 and VEGF (P < 0.05, r = -0.38), angiogenin (P < 0.0001, r = -0.68) and IL-8 (P < 0.001, r = -0.54) among smokers (smoking COPD patients and healthy smokers). No significant differences were observed between groups of healthy smokers and non-smokers. These results showed increased airway angiogenesis in patients with COPD. Moreover, VEGF, IL-8 and angiogenin negatively correlated with pulmonary function, which suggests their important role in COPD airway remodelling. However, no additional angiogenic activation was found during exacerbation of COPD.

Authors+Show Affiliations

University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia. sabina.skrgat@klinika-golnik.siNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21916917

Citation

Kristan, S S., et al. "Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease." Scandinavian Journal of Immunology, vol. 75, no. 1, 2012, pp. 109-14.
Kristan SS, Marc MM, Kern I, et al. Airway angiogenesis in stable and exacerbated chronic obstructive pulmonary disease. Scand J Immunol. 2012;75(1):109-14.
Kristan, S. S., Marc, M. M., Kern, I., Flezar, M., Suskovic, S., Kosnik, M., & Korosec, P. (2012). Airway angiogenesis in stable and exacerbated chronic obstructive pulmonary disease. Scandinavian Journal of Immunology, 75(1), 109-14. https://doi.org/10.1111/j.1365-3083.2011.02623.x
Kristan SS, et al. Airway Angiogenesis in Stable and Exacerbated Chronic Obstructive Pulmonary Disease. Scand J Immunol. 2012;75(1):109-14. PubMed PMID: 21916917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway angiogenesis in stable and exacerbated chronic obstructive pulmonary disease. AU - Kristan,S S, AU - Marc,M M, AU - Kern,I, AU - Flezar,M, AU - Suskovic,S, AU - Kosnik,M, AU - Korosec,P, PY - 2011/9/16/entrez PY - 2011/9/16/pubmed PY - 2012/2/18/medline SP - 109 EP - 14 JF - Scandinavian journal of immunology JO - Scand J Immunol VL - 75 IS - 1 N2 - Angiogenesis is a prominent feature of structural tissue remodelling that occurs in chronic airway diseases, including chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the airway levels of VEGF, angiogenin, IL-8 and TNF-α in patients with COPD during the stable phase and during acute exacerbation of the disease. We analysed induced sputum samples from 28 patients with COPD. Thirteen of these patients were followed up and second samples of sputum were obtained during acute exacerbation of the disease. The two control groups consisted of 12 healthy smokers and seven healthy non-smokers, all with normal lung function tests. Concentrations of VEGF, angiogenin, IL-8, TNF-α and bFGF were measured by cytometric bead array. In the induced sputum of patients with stable COPD, concentrations of VEGF (P < 0.001, P = 0.02), angiogenin (P < 0.0001, P < 0.0001), IL-8 (P < 0.0001, P = 0.0021) and TNF-α (P < 0.001, P = 0.03) were significantly elevated in comparison with healthy smokers and non-smokers. No additional elevation of angiogenic factors was demonstrated at the time of exacerbation. There was a significant negative correlation between FEV1 and VEGF (P < 0.05, r = -0.38), angiogenin (P < 0.0001, r = -0.68) and IL-8 (P < 0.001, r = -0.54) among smokers (smoking COPD patients and healthy smokers). No significant differences were observed between groups of healthy smokers and non-smokers. These results showed increased airway angiogenesis in patients with COPD. Moreover, VEGF, IL-8 and angiogenin negatively correlated with pulmonary function, which suggests their important role in COPD airway remodelling. However, no additional angiogenic activation was found during exacerbation of COPD. SN - 1365-3083 UR - https://www.unboundmedicine.com/medline/citation/21916917/Airway_angiogenesis_in_stable_and_exacerbated_chronic_obstructive_pulmonary_disease_ L2 - https://doi.org/10.1111/j.1365-3083.2011.02623.x DB - PRIME DP - Unbound Medicine ER -