Tags

Type your tag names separated by a space and hit enter

Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes.
Diabet Med 2012; 29(4):492-500DM

Abstract

AIMS

Skin autofluorescence, a non-invasive measure of the accumulation for advanced glycation end products, has been reported to be a useful marker for diabetic vascular risks in the Caucasian population. The aim of this study was to evaluate associations between skin autofluorescence and vascular complications in non-Caucasian patients with Type 2 diabetes.

METHODS

Subjects in this cross-sectional study comprised 130 Japanese patients with Type 2 diabetes. Skin advanced glycation end products were assessed by skin autofluorescence using an autofluorescence reader. Association between skin autofluorescence and severity of vascular complications was evaluated.

RESULTS

Of the 130 patients, 60 (46.2%) had microvascular complications such as diabetic retinopathy, neuropathy and nephropathy, 10 (7.7%) had macrovascular complications and 63 (48.5%) had micro- and/or macrovascular complications. Skin autofluorescence increased with severity of vascular complications. Independent determinants of skin autofluorescence were age (β = 0.24, P < 0.01), mean HbA(1c) in previous year (β = 0.17, P = 0.03), microvascular complications (β = 0.44, P < 0.01) and macrovascular complications (β = 0.27, P < 0.01). Multiple logistic regression analysis revealed that diabetes duration (odds ratio 1.15, P < 0.01), systolic blood pressure (odds ratio 1.04, P = 0.01), skin autofluorescence (odds ratio 3.62, P = 0.01) and serum albumin (odds ratio 0.84, P < 0.01) were independent factors for the presence of vascular complications in these patients.

CONCLUSIONS

Skin autofluorescence had independent effects on vascular complications in Japanese patients with Type 2 diabetes. This indicates that skin advanced glycation end products are a surrogate marker for vascular risk and a non-invasive autofluorescence reader may be a useful tool to detect high-risk cases in non-Caucasian patients with diabetes.

Authors+Show Affiliations

Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima, Japan. kennichi@fmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21916970

Citation

Tanaka, K, et al. "Skin Autofluorescence Is Associated With Severity of Vascular Complications in Japanese Patients With Type 2 Diabetes." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 29, no. 4, 2012, pp. 492-500.
Tanaka K, Tani Y, Asai J, et al. Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes. Diabet Med. 2012;29(4):492-500.
Tanaka, K., Tani, Y., Asai, J., Nemoto, F., Kusano, Y., Suzuki, H., ... Watanabe, T. (2012). Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association, 29(4), pp. 492-500. doi:10.1111/j.1464-5491.2011.03448.x.
Tanaka K, et al. Skin Autofluorescence Is Associated With Severity of Vascular Complications in Japanese Patients With Type 2 Diabetes. Diabet Med. 2012;29(4):492-500. PubMed PMID: 21916970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes. AU - Tanaka,K, AU - Tani,Y, AU - Asai,J, AU - Nemoto,F, AU - Kusano,Y, AU - Suzuki,H, AU - Hayashi,Y, AU - Asahi,K, AU - Nakayama,M, AU - Miyata,T, AU - Watanabe,T, PY - 2011/9/16/entrez PY - 2011/9/16/pubmed PY - 2012/7/18/medline SP - 492 EP - 500 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 29 IS - 4 N2 - AIMS: Skin autofluorescence, a non-invasive measure of the accumulation for advanced glycation end products, has been reported to be a useful marker for diabetic vascular risks in the Caucasian population. The aim of this study was to evaluate associations between skin autofluorescence and vascular complications in non-Caucasian patients with Type 2 diabetes. METHODS: Subjects in this cross-sectional study comprised 130 Japanese patients with Type 2 diabetes. Skin advanced glycation end products were assessed by skin autofluorescence using an autofluorescence reader. Association between skin autofluorescence and severity of vascular complications was evaluated. RESULTS: Of the 130 patients, 60 (46.2%) had microvascular complications such as diabetic retinopathy, neuropathy and nephropathy, 10 (7.7%) had macrovascular complications and 63 (48.5%) had micro- and/or macrovascular complications. Skin autofluorescence increased with severity of vascular complications. Independent determinants of skin autofluorescence were age (β = 0.24, P < 0.01), mean HbA(1c) in previous year (β = 0.17, P = 0.03), microvascular complications (β = 0.44, P < 0.01) and macrovascular complications (β = 0.27, P < 0.01). Multiple logistic regression analysis revealed that diabetes duration (odds ratio 1.15, P < 0.01), systolic blood pressure (odds ratio 1.04, P = 0.01), skin autofluorescence (odds ratio 3.62, P = 0.01) and serum albumin (odds ratio 0.84, P < 0.01) were independent factors for the presence of vascular complications in these patients. CONCLUSIONS: Skin autofluorescence had independent effects on vascular complications in Japanese patients with Type 2 diabetes. This indicates that skin advanced glycation end products are a surrogate marker for vascular risk and a non-invasive autofluorescence reader may be a useful tool to detect high-risk cases in non-Caucasian patients with diabetes. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/21916970/Skin_autofluorescence_is_associated_with_severity_of_vascular_complications_in_Japanese_patients_with_Type_2_diabetes_ L2 - https://doi.org/10.1111/j.1464-5491.2011.03448.x DB - PRIME DP - Unbound Medicine ER -