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Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population.
Brain Res 2011; 1417:146-50BR

Abstract

Schizophrenia is a chronic psychiatric disorder with high heritability. Schizophrenic patients with early-age onset tend to have a greater genetic component and may be an attractive subpopulation for genetic studies. Brain-derived neurotrophic factor (BDNF) is considered a candidate gene for schizophrenia. A single nucleotide polymorphism (BDNF Val66Met) was reported to be associated with schizophrenia, although discrepancy remains. The aim of this study was to evaluate the association between BDNF Val66Met polymorphism and schizophrenia using an early onset sample in the Chinese Han population. Our sample consisted of 353 schizophrenic patients with onset before age 18 and 394 healthy controls. All subjects were of an ethnically homogenous Han Chinese origin. No significant differences of genotype or allele distribution were identified between the patients and controls. However, the Met allele was significantly associated with an earlier age of onset in male schizophrenic patients (Kaplan-Meier log-rank test P=0.005), but not in females (P=0.289). The BDNF Val66Met polymorphism has an important effect on the age of onset of schizophrenia in a gender-specific manner. This may represent a significant genetic clue for the etiology of schizophrenia and thus, further studies are required to uncover the exact role of BDNF in the development of schizophrenia.

Authors+Show Affiliations

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21917241

Citation

Yi, Zhenghui, et al. "Lack of Effect of Brain Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism On Early Onset Schizophrenia in Chinese Han Population." Brain Research, vol. 1417, 2011, pp. 146-50.
Yi Z, Zhang C, Wu Z, et al. Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population. Brain Res. 2011;1417:146-50.
Yi, Z., Zhang, C., Wu, Z., Hong, W., Li, Z., Fang, Y., & Yu, S. (2011). Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population. Brain Research, 1417, pp. 146-50. doi:10.1016/j.brainres.2011.08.037.
Yi Z, et al. Lack of Effect of Brain Derived Neurotrophic Factor (BDNF) Val66Met Polymorphism On Early Onset Schizophrenia in Chinese Han Population. Brain Res. 2011 Oct 12;1417:146-50. PubMed PMID: 21917241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population. AU - Yi,Zhenghui, AU - Zhang,Chen, AU - Wu,Zhiguo, AU - Hong,Wu, AU - Li,Zezhi, AU - Fang,Yiru, AU - Yu,Shunying, Y1 - 2011/08/22/ PY - 2011/07/19/received PY - 2011/08/13/revised PY - 2011/08/16/accepted PY - 2011/9/16/entrez PY - 2011/9/16/pubmed PY - 2012/1/19/medline SP - 146 EP - 50 JF - Brain research JO - Brain Res. VL - 1417 N2 - Schizophrenia is a chronic psychiatric disorder with high heritability. Schizophrenic patients with early-age onset tend to have a greater genetic component and may be an attractive subpopulation for genetic studies. Brain-derived neurotrophic factor (BDNF) is considered a candidate gene for schizophrenia. A single nucleotide polymorphism (BDNF Val66Met) was reported to be associated with schizophrenia, although discrepancy remains. The aim of this study was to evaluate the association between BDNF Val66Met polymorphism and schizophrenia using an early onset sample in the Chinese Han population. Our sample consisted of 353 schizophrenic patients with onset before age 18 and 394 healthy controls. All subjects were of an ethnically homogenous Han Chinese origin. No significant differences of genotype or allele distribution were identified between the patients and controls. However, the Met allele was significantly associated with an earlier age of onset in male schizophrenic patients (Kaplan-Meier log-rank test P=0.005), but not in females (P=0.289). The BDNF Val66Met polymorphism has an important effect on the age of onset of schizophrenia in a gender-specific manner. This may represent a significant genetic clue for the etiology of schizophrenia and thus, further studies are required to uncover the exact role of BDNF in the development of schizophrenia. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/21917241/Lack_of_effect_of_brain_derived_neurotrophic_factor__BDNF__Val66Met_polymorphism_on_early_onset_schizophrenia_in_Chinese_Han_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(11)01542-3 DB - PRIME DP - Unbound Medicine ER -