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The impact of dialysis type on biomarkers for cardiovascular diseases.
Turk Kardiyol Dern Ars. 2011 Sep; 39(6):456-62.TK

Abstract

OBJECTIVES

The impact of dialysis type on the biomarkers that reflect the severity of cardiovascular diseases is not clearly known. We aimed to investigate the effect of dialysis type on biomarkers of cardiovascular diseases in patients with end-stage renal disease (ESRD).

STUDY DESIGN

The study included 108 patients who had been on dialysis treatment (57 patients receiving hemodialysis, 51 patients receiving peritoneal dialysis) for ESRD for at least three months. Blood samples were collected just after the dialysis. Serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), cardiac troponin I (TnI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and plasma fibrinogen levels were measured and compared between the two dialysis groups.

RESULTS

The two dialysis groups were similar with respect to age and gender. The frequency of hypertension was significantly higher in patients receiving peritoneal dialysis. This group also had higher total cholesterol, HDL cholesterol, LDL cholesterol, and hemoglobin levels. Serum levels of NT-proBNP, hs-CRP, IL-6, and TNF-α, and plasma fibrinogen levels were similar in the two dialysis groups (p>0.05), but TnI was significantly higher in patients receiving peritoneal dialysis (p=0.04). Comparison of the patient subgroups based on the duration of dialysis (<12 months, 12-36 months, and >36 months) showed that longer dialysis duration was associated with significantly lower values of NT-proBNP, TNF-α, and hs-CRP (p<0.05).

CONCLUSION

The dialysis type does not affect serum NT-proBNP, hs-CRP, IL-6, TNF-α, and plasma fibrinogen levels, but TnI level is higher in patients treated with peritoneal dialysis.

Authors+Show Affiliations

Department of Cardiology, Gazi University, Ankara, Turkey. asifesah@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21918314

Citation

Sahinarslan, Asife, et al. "The Impact of Dialysis Type On Biomarkers for Cardiovascular Diseases." Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, vol. 39, no. 6, 2011, pp. 456-62.
Sahinarslan A, Güz G, Mutluay R, et al. The impact of dialysis type on biomarkers for cardiovascular diseases. Turk Kardiyol Dern Ars. 2011;39(6):456-62.
Sahinarslan, A., Güz, G., Mutluay, R., Okyay, K., Demirtaş, C., Paşaoğlu, H., & Yalçın, R. (2011). The impact of dialysis type on biomarkers for cardiovascular diseases. Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, 39(6), 456-62. https://doi.org/10.5543/tkda.2011.01289
Sahinarslan A, et al. The Impact of Dialysis Type On Biomarkers for Cardiovascular Diseases. Turk Kardiyol Dern Ars. 2011;39(6):456-62. PubMed PMID: 21918314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of dialysis type on biomarkers for cardiovascular diseases. AU - Sahinarslan,Asife, AU - Güz,Galip, AU - Mutluay,Rüya, AU - Okyay,Kaan, AU - Demirtaş,Canan, AU - Paşaoğlu,Hatice, AU - Yalçın,Rıdvan, PY - 2011/9/16/entrez PY - 2011/9/16/pubmed PY - 2011/12/23/medline SP - 456 EP - 62 JF - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir JO - Turk Kardiyol Dern Ars VL - 39 IS - 6 N2 - OBJECTIVES: The impact of dialysis type on the biomarkers that reflect the severity of cardiovascular diseases is not clearly known. We aimed to investigate the effect of dialysis type on biomarkers of cardiovascular diseases in patients with end-stage renal disease (ESRD). STUDY DESIGN: The study included 108 patients who had been on dialysis treatment (57 patients receiving hemodialysis, 51 patients receiving peritoneal dialysis) for ESRD for at least three months. Blood samples were collected just after the dialysis. Serum N-terminal prohormone of brain natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP), cardiac troponin I (TnI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and plasma fibrinogen levels were measured and compared between the two dialysis groups. RESULTS: The two dialysis groups were similar with respect to age and gender. The frequency of hypertension was significantly higher in patients receiving peritoneal dialysis. This group also had higher total cholesterol, HDL cholesterol, LDL cholesterol, and hemoglobin levels. Serum levels of NT-proBNP, hs-CRP, IL-6, and TNF-α, and plasma fibrinogen levels were similar in the two dialysis groups (p>0.05), but TnI was significantly higher in patients receiving peritoneal dialysis (p=0.04). Comparison of the patient subgroups based on the duration of dialysis (<12 months, 12-36 months, and >36 months) showed that longer dialysis duration was associated with significantly lower values of NT-proBNP, TNF-α, and hs-CRP (p<0.05). CONCLUSION: The dialysis type does not affect serum NT-proBNP, hs-CRP, IL-6, TNF-α, and plasma fibrinogen levels, but TnI level is higher in patients treated with peritoneal dialysis. SN - 1016-5169 UR - https://www.unboundmedicine.com/medline/citation/21918314/The_impact_of_dialysis_type_on_biomarkers_for_cardiovascular_diseases_ L2 - https://www.journalagent.com/pubmed/linkout.asp?ISSN=1016-5169&amp;PMID=21918314 DB - PRIME DP - Unbound Medicine ER -