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Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status.
Arch Gynecol Obstet. 2012 Apr; 285(4):991-1000.AG

Abstract

PURPOSE

The relationship of homocysteine (Hcy), folate and vitamin B(12) with bone mineral density (BMD) has been studied in various populations but still remains inconsistent. The aim of this study was to test whether the levels of plasma Hcy, serum and red blood cell folate, and vitamin B(12) are related to BMD in the group of adult Croatian women regardless of menopausal status. Some other lifestyle and dietary habits like smoking, physical activity and alcohol consumption were also observed in relation to BMD.

METHODS

One-hundred and thirty-one women, aged 45-65 years participated in the study. BMD was measured using dual-energy X-ray absorptiometry. Measurements were made at the lumbar spine (L1-L4), left femoral neck, total femur and distal third of the radius. Plasma total Hcy, serum folate, red blood cell folate and serum vitamin B(12) were also determined.

RESULTS

No significant correlations were found between Hcy, folate and/or vitamin B(12) and BMD of measured skeletal sites. Body mass index (BMI), age, as well as alcohol consumption were significantly correlated with BMD at the lumbar spine. Positive significant correlation was found between BMI and BMD at the femoral neck and total femur while BMI and age were significant predictors of BMD at the radius (multiple regression analysis). When only postmenopausal women were included, significant predictors of BMD at the lumbar spine were age, BMI, alcohol consumption and intake of hormone replacement therapy.

CONCLUSION

Results of this study suggest that Hcy, folate or vitamin B(12) levels were not related to BMD in population of healthy Croatian women aged 45-65. In the group of postmenopausal Croatian women, beside BMI and age, alcohol consumption was significant positive predictor of BMD at the lumbar spine.

Authors+Show Affiliations

Laboratory for Food Science, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia. icecic@pbf.hrNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21918881

Citation

Rumbak, Ivana, et al. "Bone Mineral Density Is Not Associated With Homocysteine Level, Folate and Vitamin B12 Status." Archives of Gynecology and Obstetrics, vol. 285, no. 4, 2012, pp. 991-1000.
Rumbak I, Zižić V, Sokolić L, et al. Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status. Arch Gynecol Obstet. 2012;285(4):991-1000.
Rumbak, I., Zižić, V., Sokolić, L., Cvijetić, S., Kajfež, R., & Colić Barić, I. (2012). Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status. Archives of Gynecology and Obstetrics, 285(4), 991-1000. https://doi.org/10.1007/s00404-011-2079-3
Rumbak I, et al. Bone Mineral Density Is Not Associated With Homocysteine Level, Folate and Vitamin B12 Status. Arch Gynecol Obstet. 2012;285(4):991-1000. PubMed PMID: 21918881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density is not associated with homocysteine level, folate and vitamin B12 status. AU - Rumbak,Ivana, AU - Zižić,Vesna, AU - Sokolić,Lea, AU - Cvijetić,Selma, AU - Kajfež,Romana, AU - Colić Barić,Irena, Y1 - 2011/09/15/ PY - 2011/01/05/received PY - 2011/08/30/accepted PY - 2011/9/16/entrez PY - 2011/9/16/pubmed PY - 2012/7/3/medline SP - 991 EP - 1000 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 285 IS - 4 N2 - PURPOSE: The relationship of homocysteine (Hcy), folate and vitamin B(12) with bone mineral density (BMD) has been studied in various populations but still remains inconsistent. The aim of this study was to test whether the levels of plasma Hcy, serum and red blood cell folate, and vitamin B(12) are related to BMD in the group of adult Croatian women regardless of menopausal status. Some other lifestyle and dietary habits like smoking, physical activity and alcohol consumption were also observed in relation to BMD. METHODS: One-hundred and thirty-one women, aged 45-65 years participated in the study. BMD was measured using dual-energy X-ray absorptiometry. Measurements were made at the lumbar spine (L1-L4), left femoral neck, total femur and distal third of the radius. Plasma total Hcy, serum folate, red blood cell folate and serum vitamin B(12) were also determined. RESULTS: No significant correlations were found between Hcy, folate and/or vitamin B(12) and BMD of measured skeletal sites. Body mass index (BMI), age, as well as alcohol consumption were significantly correlated with BMD at the lumbar spine. Positive significant correlation was found between BMI and BMD at the femoral neck and total femur while BMI and age were significant predictors of BMD at the radius (multiple regression analysis). When only postmenopausal women were included, significant predictors of BMD at the lumbar spine were age, BMI, alcohol consumption and intake of hormone replacement therapy. CONCLUSION: Results of this study suggest that Hcy, folate or vitamin B(12) levels were not related to BMD in population of healthy Croatian women aged 45-65. In the group of postmenopausal Croatian women, beside BMI and age, alcohol consumption was significant positive predictor of BMD at the lumbar spine. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/21918881/Bone_mineral_density_is_not_associated_with_homocysteine_level_folate_and_vitamin_B12_status_ L2 - https://dx.doi.org/10.1007/s00404-011-2079-3 DB - PRIME DP - Unbound Medicine ER -