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Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children.
J Pediatr. 2012 Feb; 160(2):227-31.JPed

Abstract

OBJECTIVE

To explore the predictive value of plasma hydrogen sulfide (H(2)S) in differentiating between vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children.

STUDY DESIGN

Patients were divided between the POTS group (n=60) and VVS group (n=17) by using either the head-up test or head-up tilt test. Twenty-eight healthy children were selected for the control group. Plasma concentrations of H(2)S were determined for children in all groups (POTS, VVS, and control).

RESULTS

Plasma levels of H(2)S were significantly higher in children with VVS (95.3±3.8 μmol/L) and POTS (100.9±2.1 μmol/L) than in children in the control group (82.6±6.5 μmol/L). Compared with the VVS group, the POTS group had plasma levels of H(2)S that were significantly increased. The receiver operating characteristic curve for the predictive value of H(2)S differentiation of VVS from POTS showed a H(2)S plasma level of 98 μmol/L as the cutoff value for high probability of distinction. Such a level produced both high sensitivity (90%) and specificity (80%) rates of correctly discriminating between patients with VVS and patients with POTS.

CONCLUSION

H(2)S plasma level has both high sensitivity and specificity rates to predict the probability of correctly differentiating between patients with VVS and patients with POTS.

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Authors+Show Affiliations

Zhang F
Department of Pediatrics, Peking University First Hospital, Beijing, China.
Li X
No affiliation info available
Stella C
No affiliation info available
Chen L
No affiliation info available
Liao Y
No affiliation info available
Tang C
No affiliation info available
Jin H
No affiliation info available
Du J
No affiliation info available

MeSH

AdolescentBlood PressureChildDiagnosis, DifferentialFemaleHeart RateHumansHydrogen SulfideMalePostural Orthostatic Tachycardia SyndromePredictive Value of TestsSyncope, Vasovagal

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21920536

Citation

Zhang, Fengwen, et al. "Plasma Hydrogen Sulfide in Differential Diagnosis Between Vasovagal Syncope and Postural Orthostatic Tachycardia Syndrome in Children." The Journal of Pediatrics, vol. 160, no. 2, 2012, pp. 227-31.
Zhang F, Li X, Stella C, et al. Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children. J Pediatr. 2012;160(2):227-31.
Zhang, F., Li, X., Stella, C., Chen, L., Liao, Y., Tang, C., Jin, H., & Du, J. (2012). Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children. The Journal of Pediatrics, 160(2), 227-31. https://doi.org/10.1016/j.jpeds.2011.08.008
Zhang F, et al. Plasma Hydrogen Sulfide in Differential Diagnosis Between Vasovagal Syncope and Postural Orthostatic Tachycardia Syndrome in Children. J Pediatr. 2012;160(2):227-31. PubMed PMID: 21920536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma hydrogen sulfide in differential diagnosis between vasovagal syncope and postural orthostatic tachycardia syndrome in children. AU - Zhang,Fengwen, AU - Li,Xueying, AU - Stella,Chen, AU - Chen,Li, AU - Liao,Ying, AU - Tang,Chaoshu, AU - Jin,Hongfang, AU - Du,Junbao, Y1 - 2011/09/13/ PY - 2011/01/07/received PY - 2011/06/22/revised PY - 2011/08/01/accepted PY - 2011/9/17/entrez PY - 2011/9/17/pubmed PY - 2012/3/1/medline SP - 227 EP - 31 JF - The Journal of pediatrics JO - J Pediatr VL - 160 IS - 2 N2 - OBJECTIVE: To explore the predictive value of plasma hydrogen sulfide (H(2)S) in differentiating between vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children. STUDY DESIGN: Patients were divided between the POTS group (n=60) and VVS group (n=17) by using either the head-up test or head-up tilt test. Twenty-eight healthy children were selected for the control group. Plasma concentrations of H(2)S were determined for children in all groups (POTS, VVS, and control). RESULTS: Plasma levels of H(2)S were significantly higher in children with VVS (95.3±3.8 μmol/L) and POTS (100.9±2.1 μmol/L) than in children in the control group (82.6±6.5 μmol/L). Compared with the VVS group, the POTS group had plasma levels of H(2)S that were significantly increased. The receiver operating characteristic curve for the predictive value of H(2)S differentiation of VVS from POTS showed a H(2)S plasma level of 98 μmol/L as the cutoff value for high probability of distinction. Such a level produced both high sensitivity (90%) and specificity (80%) rates of correctly discriminating between patients with VVS and patients with POTS. CONCLUSION: H(2)S plasma level has both high sensitivity and specificity rates to predict the probability of correctly differentiating between patients with VVS and patients with POTS. SN - 1097-6833 UR - https://www.unboundmedicine.com/medline/citation/21920536/Plasma_hydrogen_sulfide_in_differential_diagnosis_between_vasovagal_syncope_and_postural_orthostatic_tachycardia_syndrome_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(11)00790-6 DB - PRIME DP - Unbound Medicine ER -