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Coffee consumption and risk of stroke: a dose-response meta-analysis of prospective studies.
Am J Epidemiol 2011; 174(9):993-1001AJ

Abstract

Coffee consumption has been inconsistently associated with risk of stroke. The authors conducted a meta-analysis of prospective studies to quantitatively assess the association between coffee consumption and stroke risk. Pertinent studies were identified by searching PubMed and Embase from January 1966 through May 2011 and by reviewing the reference lists of retrieved articles. Prospective studies in which investigators reported relative risks of stroke for 3 or more categories of coffee consumption were eligible. Results from individual studies were pooled using a random-effects model. Eleven prospective studies, with 10,003 cases of stroke and 479,689 participants, met the inclusion criteria. There was some evidence of a nonlinear association between coffee consumption and risk of stroke (P for nonlinearity = 0.005). Compared with no coffee consumption, the relative risks of stroke were 0.86 (95% confidence interval (95% CI): 0.78, 0.94) for 2 cups of coffee per day, 0.83 (95% CI: 0.74, 0.92) for 3-4 cups/day, 0.87 (95% CI: 0.77, 0.97) for 6 cups/day, and 0.93 (95% CI: 0.79, 1.08) for 8 cups/day. There was marginal between-study heterogeneity among study-specific trends (I₂ = 12% and I₂ = 20% for the first and second spline transformations, respectively). Findings from this meta-analysis indicate that moderate coffee consumption may be weakly inversely associated with risk of stroke.

Authors+Show Affiliations

Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-17177 Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21920945

Citation

Larsson, Susanna C., and Nicola Orsini. "Coffee Consumption and Risk of Stroke: a Dose-response Meta-analysis of Prospective Studies." American Journal of Epidemiology, vol. 174, no. 9, 2011, pp. 993-1001.
Larsson SC, Orsini N. Coffee consumption and risk of stroke: a dose-response meta-analysis of prospective studies. Am J Epidemiol. 2011;174(9):993-1001.
Larsson, S. C., & Orsini, N. (2011). Coffee consumption and risk of stroke: a dose-response meta-analysis of prospective studies. American Journal of Epidemiology, 174(9), pp. 993-1001. doi:10.1093/aje/kwr226.
Larsson SC, Orsini N. Coffee Consumption and Risk of Stroke: a Dose-response Meta-analysis of Prospective Studies. Am J Epidemiol. 2011 Nov 1;174(9):993-1001. PubMed PMID: 21920945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and risk of stroke: a dose-response meta-analysis of prospective studies. AU - Larsson,Susanna C, AU - Orsini,Nicola, Y1 - 2011/09/13/ PY - 2011/9/17/entrez PY - 2011/9/17/pubmed PY - 2011/12/14/medline SP - 993 EP - 1001 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 174 IS - 9 N2 - Coffee consumption has been inconsistently associated with risk of stroke. The authors conducted a meta-analysis of prospective studies to quantitatively assess the association between coffee consumption and stroke risk. Pertinent studies were identified by searching PubMed and Embase from January 1966 through May 2011 and by reviewing the reference lists of retrieved articles. Prospective studies in which investigators reported relative risks of stroke for 3 or more categories of coffee consumption were eligible. Results from individual studies were pooled using a random-effects model. Eleven prospective studies, with 10,003 cases of stroke and 479,689 participants, met the inclusion criteria. There was some evidence of a nonlinear association between coffee consumption and risk of stroke (P for nonlinearity = 0.005). Compared with no coffee consumption, the relative risks of stroke were 0.86 (95% confidence interval (95% CI): 0.78, 0.94) for 2 cups of coffee per day, 0.83 (95% CI: 0.74, 0.92) for 3-4 cups/day, 0.87 (95% CI: 0.77, 0.97) for 6 cups/day, and 0.93 (95% CI: 0.79, 1.08) for 8 cups/day. There was marginal between-study heterogeneity among study-specific trends (I₂ = 12% and I₂ = 20% for the first and second spline transformations, respectively). Findings from this meta-analysis indicate that moderate coffee consumption may be weakly inversely associated with risk of stroke. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/21920945/Coffee_consumption_and_risk_of_stroke:_a_dose_response_meta_analysis_of_prospective_studies_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr226 DB - PRIME DP - Unbound Medicine ER -