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Synergy of glutathione, dithiothreitol and N-acetyl-L-cysteine self-assembled monolayers for electrochemical assay: sensitive determination of arsenic(III) in environmental and drinking water.
Analyst. 2011 Nov 07; 136(21):4526-32.A

Abstract

A simple and efficient electrochemical assay based on self-assembled monolayers (SAMs) was developed for the highly sensitive determination of arsenic(III) in water samples. The synergy of glutathione (GSH), dithiothreitol (DTT) and N-acetyl-L-cysteine (NAC) mixed SAMs enhanced the detection specificity and sensitivity of As(III) in water samples, resulting from the immobilization of a large number of As(III) moieties on the gold electrode surface via As-O and As-S linkages. After accumulating As(III), anodic stripping voltammetry (ASV) was performed, and linear sweep voltammetry (LSV) was employed for signal recording. Several main voltammetric parameters were optimized as follows: supporting electrolyte, 1 mol L(-1) HCl; deposition potential, -0.35 V; deposition time, 150 s. A good linear relationship (R = 0.9980) was attained between the concentration of the As(III) standard and peak current, in the range of 3-100 μg L(-1). The limit of detection (LOD) of this sensing system was determined to be 0.5 μg L(-1) at a signal-to-noise ratio of 3. A variety of common coexistent ions in water samples were examined, showing no obvious interferences on the As(III) determination. The amenability of this method to the analyses of water samples was also investigated. High recovery of 90.5% with the precision of 5.1% at spiked 10 μg L(-1), and low LOD of 0.3 μg L(-1) were obtained in seawater. The synergy effect of GSH, DTT and NAC provided the possibility for the rapid and sensitive LSV determination of As(III) in complicated water samples.

Authors+Show Affiliations

Key Laboratory of Coastal Zone Environmental Processes, CAS, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. lxchen@yic.ac.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21922099

Citation

Chen, Lingxin, et al. "Synergy of Glutathione, Dithiothreitol and N-acetyl-L-cysteine Self-assembled Monolayers for Electrochemical Assay: Sensitive Determination of arsenic(III) in Environmental and Drinking Water." The Analyst, vol. 136, no. 21, 2011, pp. 4526-32.
Chen L, Zhou N, Li J, et al. Synergy of glutathione, dithiothreitol and N-acetyl-L-cysteine self-assembled monolayers for electrochemical assay: sensitive determination of arsenic(III) in environmental and drinking water. Analyst. 2011;136(21):4526-32.
Chen, L., Zhou, N., Li, J., Chen, Z., Liao, C., & Chen, J. (2011). Synergy of glutathione, dithiothreitol and N-acetyl-L-cysteine self-assembled monolayers for electrochemical assay: sensitive determination of arsenic(III) in environmental and drinking water. The Analyst, 136(21), 4526-32. https://doi.org/10.1039/c1an15454k
Chen L, et al. Synergy of Glutathione, Dithiothreitol and N-acetyl-L-cysteine Self-assembled Monolayers for Electrochemical Assay: Sensitive Determination of arsenic(III) in Environmental and Drinking Water. Analyst. 2011 Nov 7;136(21):4526-32. PubMed PMID: 21922099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergy of glutathione, dithiothreitol and N-acetyl-L-cysteine self-assembled monolayers for electrochemical assay: sensitive determination of arsenic(III) in environmental and drinking water. AU - Chen,Lingxin, AU - Zhou,Na, AU - Li,Jinhua, AU - Chen,Zhaopeng, AU - Liao,Chunyang, AU - Chen,Jiannong, Y1 - 2011/09/16/ PY - 2011/9/17/entrez PY - 2011/9/17/pubmed PY - 2012/4/4/medline SP - 4526 EP - 32 JF - The Analyst JO - Analyst VL - 136 IS - 21 N2 - A simple and efficient electrochemical assay based on self-assembled monolayers (SAMs) was developed for the highly sensitive determination of arsenic(III) in water samples. The synergy of glutathione (GSH), dithiothreitol (DTT) and N-acetyl-L-cysteine (NAC) mixed SAMs enhanced the detection specificity and sensitivity of As(III) in water samples, resulting from the immobilization of a large number of As(III) moieties on the gold electrode surface via As-O and As-S linkages. After accumulating As(III), anodic stripping voltammetry (ASV) was performed, and linear sweep voltammetry (LSV) was employed for signal recording. Several main voltammetric parameters were optimized as follows: supporting electrolyte, 1 mol L(-1) HCl; deposition potential, -0.35 V; deposition time, 150 s. A good linear relationship (R = 0.9980) was attained between the concentration of the As(III) standard and peak current, in the range of 3-100 μg L(-1). The limit of detection (LOD) of this sensing system was determined to be 0.5 μg L(-1) at a signal-to-noise ratio of 3. A variety of common coexistent ions in water samples were examined, showing no obvious interferences on the As(III) determination. The amenability of this method to the analyses of water samples was also investigated. High recovery of 90.5% with the precision of 5.1% at spiked 10 μg L(-1), and low LOD of 0.3 μg L(-1) were obtained in seawater. The synergy effect of GSH, DTT and NAC provided the possibility for the rapid and sensitive LSV determination of As(III) in complicated water samples. SN - 1364-5528 UR - https://www.unboundmedicine.com/medline/citation/21922099/Synergy_of_glutathione_dithiothreitol_and_N_acetyl_L_cysteine_self_assembled_monolayers_for_electrochemical_assay:_sensitive_determination_of_arsenic_III__in_environmental_and_drinking_water_ L2 - https://doi.org/10.1039/c1an15454k DB - PRIME DP - Unbound Medicine ER -