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Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer.
Surg Today. 2011 Oct; 41(10):1370-9.ST

Abstract

PURPOSE

This study aimed to assess the prognostic value of the lymph node ratio (LNR), estimated by dividing the number of positive lymph nodes (LNs) by the number of LNs examined, for stage III colorectal cancer in comparison to the new tumor, nodes, and metastasis (TNM) system, and to evaluate the relationship between the number of LNs examined and the prognostic value of the LNR.

METHODS

We retrospectively reviewed the clinicopathological data of a cohort of 266 patients with stage III colorectal cancer. We assessed the impact of LNR on the prediction of cancer recurrence in comparison to the TNM system, as well as the prognostic value of LNR in patients with a low LN count.

RESULTS

In multivariate analysis, the LNR was found to be an independent risk factor of cancer recurrence. The application of the LNR, in addition to the new TNM system, was more predictive of survival than the TNM system alone. A prognostic separation by LNR was observed in patients who had an adequate number of LNs examined, but not in patients with a low LN count.

CONCLUSIONS

A stronger prognostic separation can be obtained by using the LNR together with the new TNM system. Adequate lymph node examination is important to ensure the prognostic value of LNR in patients with stage III colorectal cancer.

Authors+Show Affiliations

Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21922359

Citation

Shimomura, Manabu, et al. "Adequate Lymph Node Examination Is Essential to Ensure the Prognostic Value of the Lymph Node Ratio in Patients With Stage III Colorectal Cancer." Surgery Today, vol. 41, no. 10, 2011, pp. 1370-9.
Shimomura M, Ikeda S, Takakura Y, et al. Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer. Surg Today. 2011;41(10):1370-9.
Shimomura, M., Ikeda, S., Takakura, Y., Kawaguchi, Y., Tokunaga, M., Egi, H., Hinoi, T., Okajima, M., & Ohdan, H. (2011). Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer. Surgery Today, 41(10), 1370-9. https://doi.org/10.1007/s00595-010-4446-2
Shimomura M, et al. Adequate Lymph Node Examination Is Essential to Ensure the Prognostic Value of the Lymph Node Ratio in Patients With Stage III Colorectal Cancer. Surg Today. 2011;41(10):1370-9. PubMed PMID: 21922359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer. AU - Shimomura,Manabu, AU - Ikeda,Satoshi, AU - Takakura,Yuji, AU - Kawaguchi,Yasuo, AU - Tokunaga,Masakazu, AU - Egi,Hiroyuki, AU - Hinoi,Takao, AU - Okajima,Masazumi, AU - Ohdan,Hideki, Y1 - 2011/09/16/ PY - 2010/09/03/received PY - 2010/10/18/accepted PY - 2011/9/17/entrez PY - 2011/9/17/pubmed PY - 2012/4/4/medline SP - 1370 EP - 9 JF - Surgery today JO - Surg. Today VL - 41 IS - 10 N2 - PURPOSE: This study aimed to assess the prognostic value of the lymph node ratio (LNR), estimated by dividing the number of positive lymph nodes (LNs) by the number of LNs examined, for stage III colorectal cancer in comparison to the new tumor, nodes, and metastasis (TNM) system, and to evaluate the relationship between the number of LNs examined and the prognostic value of the LNR. METHODS: We retrospectively reviewed the clinicopathological data of a cohort of 266 patients with stage III colorectal cancer. We assessed the impact of LNR on the prediction of cancer recurrence in comparison to the TNM system, as well as the prognostic value of LNR in patients with a low LN count. RESULTS: In multivariate analysis, the LNR was found to be an independent risk factor of cancer recurrence. The application of the LNR, in addition to the new TNM system, was more predictive of survival than the TNM system alone. A prognostic separation by LNR was observed in patients who had an adequate number of LNs examined, but not in patients with a low LN count. CONCLUSIONS: A stronger prognostic separation can be obtained by using the LNR together with the new TNM system. Adequate lymph node examination is important to ensure the prognostic value of LNR in patients with stage III colorectal cancer. SN - 1436-2813 UR - https://www.unboundmedicine.com/medline/citation/21922359/Adequate_lymph_node_examination_is_essential_to_ensure_the_prognostic_value_of_the_lymph_node_ratio_in_patients_with_stage_III_colorectal_cancer_ L2 - https://dx.doi.org/10.1007/s00595-010-4446-2 DB - PRIME DP - Unbound Medicine ER -