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Identification of benzophenone C-glucosides from mango tree leaves and their inhibitory effect on triglyceride accumulation in 3T3-L1 adipocytes.
J Agric Food Chem. 2011 Nov 09; 59(21):11526-33.JA

Abstract

A 70% ethanol-water extract from the leaves of Mangifera indica L. (Anacardiaceae) inhibited triglyceride (TG) accumulation in 3T3-L1 cells. From the active fraction, seven new benzophenone C-glycosides, foliamangiferosides A (1), A(1) (2), A(2) (3), B (4), C(1) (5), C(2) (6), and C(3) (7), together with five known compounds were isolated and the structures were elucidated on the basis of chemical and physicochemical evidence. The effects of these compounds on TG and the free fatty acid level in 3T3-L1 cells were determined, and the structure-activity relationship was discussed. On the basis of the AMPK signaling pathway, several compounds were found to increase the AMPK enzyme expression and down-regulate lipogenic enzyme gene expression such as SREBP1c, FAS, and HSL.

Authors+Show Affiliations

Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21923172

Citation

Zhang, Yi, et al. "Identification of Benzophenone C-glucosides From Mango Tree Leaves and Their Inhibitory Effect On Triglyceride Accumulation in 3T3-L1 Adipocytes." Journal of Agricultural and Food Chemistry, vol. 59, no. 21, 2011, pp. 11526-33.
Zhang Y, Qian Q, Ge D, et al. Identification of benzophenone C-glucosides from mango tree leaves and their inhibitory effect on triglyceride accumulation in 3T3-L1 adipocytes. J Agric Food Chem. 2011;59(21):11526-33.
Zhang, Y., Qian, Q., Ge, D., Li, Y., Wang, X., Chen, Q., Gao, X., & Wang, T. (2011). Identification of benzophenone C-glucosides from mango tree leaves and their inhibitory effect on triglyceride accumulation in 3T3-L1 adipocytes. Journal of Agricultural and Food Chemistry, 59(21), 11526-33. https://doi.org/10.1021/jf2028494
Zhang Y, et al. Identification of Benzophenone C-glucosides From Mango Tree Leaves and Their Inhibitory Effect On Triglyceride Accumulation in 3T3-L1 Adipocytes. J Agric Food Chem. 2011 Nov 9;59(21):11526-33. PubMed PMID: 21923172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of benzophenone C-glucosides from mango tree leaves and their inhibitory effect on triglyceride accumulation in 3T3-L1 adipocytes. AU - Zhang,Yi, AU - Qian,Qian, AU - Ge,Dandan, AU - Li,Yuhong, AU - Wang,Xinrui, AU - Chen,Qiu, AU - Gao,Xiumei, AU - Wang,Tao, Y1 - 2011/10/11/ PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2012/2/23/medline SP - 11526 EP - 33 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 59 IS - 21 N2 - A 70% ethanol-water extract from the leaves of Mangifera indica L. (Anacardiaceae) inhibited triglyceride (TG) accumulation in 3T3-L1 cells. From the active fraction, seven new benzophenone C-glycosides, foliamangiferosides A (1), A(1) (2), A(2) (3), B (4), C(1) (5), C(2) (6), and C(3) (7), together with five known compounds were isolated and the structures were elucidated on the basis of chemical and physicochemical evidence. The effects of these compounds on TG and the free fatty acid level in 3T3-L1 cells were determined, and the structure-activity relationship was discussed. On the basis of the AMPK signaling pathway, several compounds were found to increase the AMPK enzyme expression and down-regulate lipogenic enzyme gene expression such as SREBP1c, FAS, and HSL. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/21923172/Identification_of_benzophenone_C_glucosides_from_mango_tree_leaves_and_their_inhibitory_effect_on_triglyceride_accumulation_in_3T3_L1_adipocytes_ L2 - https://doi.org/10.1021/jf2028494 DB - PRIME DP - Unbound Medicine ER -