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Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction.
J Forensic Sci. 2012 Jan; 57(1):228-33.JF

Abstract

A rapid and simple gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous detection and quantification of five psychotropic phenylalkylamines (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and norketamine) in toenails. After external decontamination, nail clippings were mechanically pulverized with a bead mill and then incubated in methanol under ultrasonication at 50°C for 1 h. The resulting solutions were evaporated to dryness, derivatized, and analyzed by GC-MS. The intra- and inter-day precisions were within 10.7% and 13.9%, respectively. The intra- and inter-day accuracies were -4.2% to 5.0% and -2.4% to 8.4%, respectively. Limits of detection and quantification for each analyte were lower than 0.024 and 0.08 ng/mg, respectively. The recoveries were in the range of 80.6-87.5%. The results indicated that the proposed method is a simple, rapid, accurate, and precise for quantification of five phenylalkylamines in nails. The method was successfully applied to the simultaneous detection and quantification of phenylalkylamines in nail samples of possible drug abusers.

Authors+Show Affiliations

Drug Analysis Laboratory, Forensic Science Division, Supreme Prosecutors' Office, Seoul, Korea. paxus@spo.go.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

21923795

Citation

Kim, Jin Young, et al. "Rapid and Simple GC-MS Method for Determination of Psychotropic Phenylalkylamine Derivatives in Nails Using Micro-pulverized Extraction." Journal of Forensic Sciences, vol. 57, no. 1, 2012, pp. 228-33.
Kim JY, Cheong JC, Lee JI, et al. Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction. J Forensic Sci. 2012;57(1):228-33.
Kim, J. Y., Cheong, J. C., Lee, J. I., Son, J. H., & In, M. K. (2012). Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction. Journal of Forensic Sciences, 57(1), 228-33. https://doi.org/10.1111/j.1556-4029.2011.01913.x
Kim JY, et al. Rapid and Simple GC-MS Method for Determination of Psychotropic Phenylalkylamine Derivatives in Nails Using Micro-pulverized Extraction. J Forensic Sci. 2012;57(1):228-33. PubMed PMID: 21923795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid and simple GC-MS method for determination of psychotropic phenylalkylamine derivatives in nails using micro-pulverized extraction. AU - Kim,Jin Young, AU - Cheong,Jae Chul, AU - Lee,Jae Il, AU - Son,Ju Hee, AU - In,Moon Kyo, Y1 - 2011/09/16/ PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2012/4/28/medline SP - 228 EP - 33 JF - Journal of forensic sciences JO - J Forensic Sci VL - 57 IS - 1 N2 - A rapid and simple gas chromatography-mass spectrometry (GC-MS) method was developed and validated for the simultaneous detection and quantification of five psychotropic phenylalkylamines (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and norketamine) in toenails. After external decontamination, nail clippings were mechanically pulverized with a bead mill and then incubated in methanol under ultrasonication at 50°C for 1 h. The resulting solutions were evaporated to dryness, derivatized, and analyzed by GC-MS. The intra- and inter-day precisions were within 10.7% and 13.9%, respectively. The intra- and inter-day accuracies were -4.2% to 5.0% and -2.4% to 8.4%, respectively. Limits of detection and quantification for each analyte were lower than 0.024 and 0.08 ng/mg, respectively. The recoveries were in the range of 80.6-87.5%. The results indicated that the proposed method is a simple, rapid, accurate, and precise for quantification of five phenylalkylamines in nails. The method was successfully applied to the simultaneous detection and quantification of phenylalkylamines in nail samples of possible drug abusers. SN - 1556-4029 UR - https://www.unboundmedicine.com/medline/citation/21923795/Rapid_and_simple_GC_MS_method_for_determination_of_psychotropic_phenylalkylamine_derivatives_in_nails_using_micro_pulverized_extraction_ L2 - https://doi.org/10.1111/j.1556-4029.2011.01913.x DB - PRIME DP - Unbound Medicine ER -