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The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats.
J Ethnopharmacol. 2011 Oct 31; 138(1):142-9.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Leaves of Lithocarpus polystachyus Rehd. are used for the treatment of disorders such as diabetes, hypertension, and epilepsy in folk medicine of South China. The possible antidiabetic effects of the leaves were investigated in experimental type 2 and type 1 diabetic rats.

MATERIALS AND METHODS

Type 2 diabetic rats received orally three different extracts of Lithocarpus polystachyus Rehd. leaves for 4 weeks (aqueous extract [ST-1], ethanol extract [ST-2], flavonoid-rich fraction [ST-3]). At the end of the experiment biochemical parameters were tested and livers and pancreases were excised for histological study. After the comparison of the pharmacological test results of the three extracts, the one which showed the best bioactivity was further studied to confirm its antidiabetes effect on both type 2 and type 1 diabetic rats.

RESULTS

Compared to ST-1 and ST-2, ST-3 had better effects on regulation of blood glucose, glycosylated serum protein, cholesterol, triglyceride, malondialdehyde, superoxide dismutase and attenuation of liver injury in type 2 diabetic rats (p<0.01 or p<0.05). ST-3 administration for four weeks also significantly reduced the fasting serum insulin and C-peptide level and improved the insulin tolerance (p<0.05). In type 1 diabetic rats, ST-3 supplement for three weeks caused significant reduction in fasting blood glucose, total cholesterol, triglyceride, urea nitrogen, creatinine and liver mass, along with significantly inhibiting the decline of insulin level compared to diabetic control (p<0.05 or p<0.01).

CONCLUSION

The flavonoid-rich fraction of Lithocarpus polystachyus Rehd. leaves (ST-3) had better beneficial effect than that of the ethanol or aqueous extract in experimental diabetic rats, which means that the bioactivity of the herbal leaves is probably due to the presence of flavonoids. The results also strongly suggest that the antidiabetic effect of ST-3 was possibly through multiple mechanisms of action including blood lipid and antioxidant mediation. The results indicated that the aqueous flavonoid-rich fraction of Lithocarpus polystachyus Rehd. leaves possessed significant protective activity in type 2 and type 1 diabetes.

Authors+Show Affiliations

School of Chinese Pharmaceutical Science, Guangzhou University of Chinese Medicine, University Town, Guangzhou 510006, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21924344

Citation

Hou, Shao-Zhen, et al. "The Hypoglycemic Activity of Lithocarpus Polystachyus Rehd. Leaves in the Experimental Hyperglycemic Rats." Journal of Ethnopharmacology, vol. 138, no. 1, 2011, pp. 142-9.
Hou SZ, Chen SX, Huang S, et al. The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats. J Ethnopharmacol. 2011;138(1):142-9.
Hou, S. Z., Chen, S. X., Huang, S., Jiang, D. X., Zhou, C. J., Chen, C. Q., Liang, Y. M., & Lai, X. P. (2011). The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats. Journal of Ethnopharmacology, 138(1), 142-9. https://doi.org/10.1016/j.jep.2011.08.067
Hou SZ, et al. The Hypoglycemic Activity of Lithocarpus Polystachyus Rehd. Leaves in the Experimental Hyperglycemic Rats. J Ethnopharmacol. 2011 Oct 31;138(1):142-9. PubMed PMID: 21924344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats. AU - Hou,Shao-Zhen, AU - Chen,Shu-Xian, AU - Huang,Song, AU - Jiang,Dong-Xu, AU - Zhou,Cai-Jie, AU - Chen,Chang-Qing, AU - Liang,Ying-Min, AU - Lai,Xiao-Ping, Y1 - 2011/09/08/ PY - 2011/04/27/received PY - 2011/08/14/revised PY - 2011/08/29/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2012/5/4/medline SP - 142 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 138 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Leaves of Lithocarpus polystachyus Rehd. are used for the treatment of disorders such as diabetes, hypertension, and epilepsy in folk medicine of South China. The possible antidiabetic effects of the leaves were investigated in experimental type 2 and type 1 diabetic rats. MATERIALS AND METHODS: Type 2 diabetic rats received orally three different extracts of Lithocarpus polystachyus Rehd. leaves for 4 weeks (aqueous extract [ST-1], ethanol extract [ST-2], flavonoid-rich fraction [ST-3]). At the end of the experiment biochemical parameters were tested and livers and pancreases were excised for histological study. After the comparison of the pharmacological test results of the three extracts, the one which showed the best bioactivity was further studied to confirm its antidiabetes effect on both type 2 and type 1 diabetic rats. RESULTS: Compared to ST-1 and ST-2, ST-3 had better effects on regulation of blood glucose, glycosylated serum protein, cholesterol, triglyceride, malondialdehyde, superoxide dismutase and attenuation of liver injury in type 2 diabetic rats (p<0.01 or p<0.05). ST-3 administration for four weeks also significantly reduced the fasting serum insulin and C-peptide level and improved the insulin tolerance (p<0.05). In type 1 diabetic rats, ST-3 supplement for three weeks caused significant reduction in fasting blood glucose, total cholesterol, triglyceride, urea nitrogen, creatinine and liver mass, along with significantly inhibiting the decline of insulin level compared to diabetic control (p<0.05 or p<0.01). CONCLUSION: The flavonoid-rich fraction of Lithocarpus polystachyus Rehd. leaves (ST-3) had better beneficial effect than that of the ethanol or aqueous extract in experimental diabetic rats, which means that the bioactivity of the herbal leaves is probably due to the presence of flavonoids. The results also strongly suggest that the antidiabetic effect of ST-3 was possibly through multiple mechanisms of action including blood lipid and antioxidant mediation. The results indicated that the aqueous flavonoid-rich fraction of Lithocarpus polystachyus Rehd. leaves possessed significant protective activity in type 2 and type 1 diabetes. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21924344/The_hypoglycemic_activity_of_Lithocarpus_polystachyus_Rehd__leaves_in_the_experimental_hyperglycemic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00640-4 DB - PRIME DP - Unbound Medicine ER -