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Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial.
Fertil Steril. 2011 Nov; 96(5):1112-5.FS

Abstract

OBJECTIVE

To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF.

DESIGN

Prospective randomized controlled clinical trial.

SETTING

Dutch-speaking Free University of Brussels.

PATIENT(S)

One hundred twenty patients, aged <40 years, treated by IVF or intracytoplasmic sperm injection.

INTERVENTION(S)

Ovarian stimulation was achieved using recombinant FSH starting on day 2 of the menstrual cycle at a fixed dose. To inhibit premature LH surge, daily GnRH antagonist was used from day 6 of stimulation. Triggering of final oocyte maturation was performed using 10,000 IU of hCG. Patients were randomized to receive hCG either as soon as three or more follicles of size ≥16 mm were present on ultrasonography (early-hCG group) or 1 day after the above criterion was met (late-hCG group).

MAIN OUTCOME MEASURE(S)

Ongoing pregnancy rate.

RESULT(S)

Significant differences were observed between the early-hCG and the late-hCG group regarding E(2) (1,388 ± 931 [mean ± SD] vs. 2,040 ± 1,231 pg/mL, respectively) and P (0.8 ± 0.3 vs. 1.1 ± 0.5 ng/mL, respectively) levels on the day of hCG administration and the number of metaphase II oocytes (9.2 ± 7.1 vs. 6.1 ± 4.9, respectively). No significant differences were observed between the early-hCG and the late-hCG group regarding positive hCG (46.2% vs. 50%, respectively) and ongoing pregnancy rates (34.6% vs. 40.7%, respectively).

CONCLUSION(S)

The current study provides evidence that earlier administration of hCG is not associated with the probability of pregnancy in cycles stimulated with recombinant FSH and GnRH antagonists.

Authors+Show Affiliations

Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. mimikyrou@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21924414

Citation

Kyrou, Dimitra, et al. "Is Earlier Administration of Human Chorionic Gonadotropin (hCG) Associated With the Probability of Pregnancy in Cycles Stimulated With Recombinant Follicle-stimulating Hormone and Gonadotropin-releasing Hormone (GnRH) Antagonists? a Prospective Randomized Trial." Fertility and Sterility, vol. 96, no. 5, 2011, pp. 1112-5.
Kyrou D, Kolibianakis EM, Fatemi HM, et al. Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial. Fertil Steril. 2011;96(5):1112-5.
Kyrou, D., Kolibianakis, E. M., Fatemi, H. M., Tarlatzis, B. C., Tournaye, H., & Devroey, P. (2011). Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial. Fertility and Sterility, 96(5), 1112-5. https://doi.org/10.1016/j.fertnstert.2011.08.029
Kyrou D, et al. Is Earlier Administration of Human Chorionic Gonadotropin (hCG) Associated With the Probability of Pregnancy in Cycles Stimulated With Recombinant Follicle-stimulating Hormone and Gonadotropin-releasing Hormone (GnRH) Antagonists? a Prospective Randomized Trial. Fertil Steril. 2011;96(5):1112-5. PubMed PMID: 21924414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial. AU - Kyrou,Dimitra, AU - Kolibianakis,Efstratios M, AU - Fatemi,Human M, AU - Tarlatzis,Basil C, AU - Tournaye,Herman, AU - Devroey,Paul, Y1 - 2011/09/15/ PY - 2011/07/14/received PY - 2011/08/06/revised PY - 2011/08/17/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2011/12/16/medline SP - 1112 EP - 5 JF - Fertility and sterility JO - Fertil. Steril. VL - 96 IS - 5 N2 - OBJECTIVE: To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF. DESIGN: Prospective randomized controlled clinical trial. SETTING: Dutch-speaking Free University of Brussels. PATIENT(S): One hundred twenty patients, aged <40 years, treated by IVF or intracytoplasmic sperm injection. INTERVENTION(S): Ovarian stimulation was achieved using recombinant FSH starting on day 2 of the menstrual cycle at a fixed dose. To inhibit premature LH surge, daily GnRH antagonist was used from day 6 of stimulation. Triggering of final oocyte maturation was performed using 10,000 IU of hCG. Patients were randomized to receive hCG either as soon as three or more follicles of size ≥16 mm were present on ultrasonography (early-hCG group) or 1 day after the above criterion was met (late-hCG group). MAIN OUTCOME MEASURE(S): Ongoing pregnancy rate. RESULT(S): Significant differences were observed between the early-hCG and the late-hCG group regarding E(2) (1,388 ± 931 [mean ± SD] vs. 2,040 ± 1,231 pg/mL, respectively) and P (0.8 ± 0.3 vs. 1.1 ± 0.5 ng/mL, respectively) levels on the day of hCG administration and the number of metaphase II oocytes (9.2 ± 7.1 vs. 6.1 ± 4.9, respectively). No significant differences were observed between the early-hCG and the late-hCG group regarding positive hCG (46.2% vs. 50%, respectively) and ongoing pregnancy rates (34.6% vs. 40.7%, respectively). CONCLUSION(S): The current study provides evidence that earlier administration of hCG is not associated with the probability of pregnancy in cycles stimulated with recombinant FSH and GnRH antagonists. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/21924414/Is_earlier_administration_of_human_chorionic_gonadotropin__hCG__associated_with_the_probability_of_pregnancy_in_cycles_stimulated_with_recombinant_follicle_stimulating_hormone_and_gonadotropin_releasing_hormone__GnRH__antagonists_A_prospective_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(11)02474-5 DB - PRIME DP - Unbound Medicine ER -