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Folate and risk of coronary heart disease: a meta-analysis of prospective studies.
Nutr Metab Cardiovasc Dis 2012; 22(10):890-9NM

Abstract

BACKGROUND AND AIMS

Epidemiologic studies are inconsistent regarding the association between folate and coronary heart disease (CHD) risk. The aim was to perform a meta-analysis to determine whether an association exists between folate and total CHD endpoints in prospective studies.

METHODS AND RESULTS

We searched the PUBMED and EMBASE databases for studies conducted from 1966 through August 2010. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random effects model. A total of 14 studies were included in the meta-analysis: 7 studies on dietary folate intake and 8 studies on blood folate levels. For dietary intake, the summary relative risk (RR) indicated a significant association between the highest folate intake and reduced risk of CHD (summary RR: 0.69; 95% CI: 0.60, 0.80). Furthermore, an increase in folate intake of 200 ug/day was associated with a 12% decrease in the risk of developing CHD (summary RR: 0.88; 95% CI: 0.82, 0.94). For blood folate levels, we also found a borderline inverse association of highest blood folate levels on CHD risk (summary RR: 0.74; 95% CI: 0.53, 1.02); our dose-response analysis indicated that an increment in blood folate levels of 5 mmol/l was associated with an 8% decrease in the risk of developing CHD (summary RR: 0.92; 95% CI: 0.84, 1.00).

CONCLUSION

This meta-analysis suggests that dietary folate intake and blood folate level are inversely associated with CHD risk.

Authors+Show Affiliations

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21924595

Citation

Wang, Z-M, et al. "Folate and Risk of Coronary Heart Disease: a Meta-analysis of Prospective Studies." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 22, no. 10, 2012, pp. 890-9.
Wang ZM, Zhou B, Nie ZL, et al. Folate and risk of coronary heart disease: a meta-analysis of prospective studies. Nutr Metab Cardiovasc Dis. 2012;22(10):890-9.
Wang, Z. M., Zhou, B., Nie, Z. L., Gao, W., Wang, Y. S., Zhao, H., ... Wang, L. S. (2012). Folate and risk of coronary heart disease: a meta-analysis of prospective studies. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 22(10), pp. 890-9. doi:10.1016/j.numecd.2011.04.011.
Wang ZM, et al. Folate and Risk of Coronary Heart Disease: a Meta-analysis of Prospective Studies. Nutr Metab Cardiovasc Dis. 2012;22(10):890-9. PubMed PMID: 21924595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate and risk of coronary heart disease: a meta-analysis of prospective studies. AU - Wang,Z-M, AU - Zhou,B, AU - Nie,Z-L, AU - Gao,W, AU - Wang,Y-S, AU - Zhao,H, AU - Zhu,J, AU - Yan,J-J, AU - Yang,Z-J, AU - Wang,L-S, Y1 - 2011/09/15/ PY - 2011/02/11/received PY - 2011/04/15/revised PY - 2011/04/19/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2013/2/8/medline SP - 890 EP - 9 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 22 IS - 10 N2 - BACKGROUND AND AIMS: Epidemiologic studies are inconsistent regarding the association between folate and coronary heart disease (CHD) risk. The aim was to perform a meta-analysis to determine whether an association exists between folate and total CHD endpoints in prospective studies. METHODS AND RESULTS: We searched the PUBMED and EMBASE databases for studies conducted from 1966 through August 2010. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random effects model. A total of 14 studies were included in the meta-analysis: 7 studies on dietary folate intake and 8 studies on blood folate levels. For dietary intake, the summary relative risk (RR) indicated a significant association between the highest folate intake and reduced risk of CHD (summary RR: 0.69; 95% CI: 0.60, 0.80). Furthermore, an increase in folate intake of 200 ug/day was associated with a 12% decrease in the risk of developing CHD (summary RR: 0.88; 95% CI: 0.82, 0.94). For blood folate levels, we also found a borderline inverse association of highest blood folate levels on CHD risk (summary RR: 0.74; 95% CI: 0.53, 1.02); our dose-response analysis indicated that an increment in blood folate levels of 5 mmol/l was associated with an 8% decrease in the risk of developing CHD (summary RR: 0.92; 95% CI: 0.84, 1.00). CONCLUSION: This meta-analysis suggests that dietary folate intake and blood folate level are inversely associated with CHD risk. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/21924595/Folate_and_risk_of_coronary_heart_disease:_a_meta_analysis_of_prospective_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(11)00106-2 DB - PRIME DP - Unbound Medicine ER -