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Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults.
Nutr Metab Cardiovasc Dis. 2013 Apr; 23(4):350-7.NM

Abstract

BACKGROUND AND AIMS

The well-established triglyceride (TG) lowering effect of fish oil is accompanied by an increase in LDL-cholesterol (LDL-C) concentration. Less is known about the differential impact on LDL particle distribution - the smaller particles being associated with a greater risk for atherosclerosis. We aimed to examine the changes in serum concentrations of four subclasses of LDL particles as well as shifts in LDL phenotype patterns (A, B, AB) among hypertriglyceridemic adults.

METHODS AND RESULTS

This was a secondary analysis from a double-blind, parallel design, placebo controlled trial with 42 adults that experienced significant TG lowering and modest increases in total LDL-C concentrations after 12 weeks of 4 g/d EPA + DHA. Reduction in serum TG concentrations (mean ± SEM) was -26 ± 4% (-0.81 ± 10.12 mmol/L), p < 0.0001. Total LDL-C concentration increased by 13 ± 3% (+0.31 ± 0.08 mmol/L), p < 0.0001. The 12-week changes in concentrations of LDL1, LDL2, LDL3 and LDL4 were +0.06 ± 0.02 mmol/L [+2.2 ± 0.7 mg/dL], +0.07 ± 0.03 mmol/L [+2.6 ± 1.0 mg/dL], +0.16 ± 0.05 mmol/L [+6.3 ± 1.8 mg/dL], and +0.04 ± 0.04 mmol/L [+1.4 ± 1.7 mg/dL], respectively (+20 ± 5%, +64 ± 13%, +26 ± 6%, and +17 ± 9%), p < 0.05 for all but LDL4. Changes in LDL phenotype patterns A, B and A/B were negligible and not statistically significant.

CONCLUSION

In this population of hypertriglyceridemic adults, dietary supplementation with fish oil resulted in an increase in total LDL-C concentration which was distributed relatively evenly across the range of smaller and more atherogenic as well as larger and less atherogenic LDL particles.

Authors+Show Affiliations

Stanford Prevention Research Center and the Department of Medicine, Stanford University Medical School, 1265 Welch Road, SPRC X310, Stanford, CA 94305-5411, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21924882

Citation

Oelrich, B, et al. "Effect of Fish Oil Supplementation On Serum Triglycerides, LDL Cholesterol and LDL Subfractions in Hypertriglyceridemic Adults." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 4, 2013, pp. 350-7.
Oelrich B, Dewell A, Gardner CD. Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. Nutr Metab Cardiovasc Dis. 2013;23(4):350-7.
Oelrich, B., Dewell, A., & Gardner, C. D. (2013). Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(4), 350-7. https://doi.org/10.1016/j.numecd.2011.06.003
Oelrich B, Dewell A, Gardner CD. Effect of Fish Oil Supplementation On Serum Triglycerides, LDL Cholesterol and LDL Subfractions in Hypertriglyceridemic Adults. Nutr Metab Cardiovasc Dis. 2013;23(4):350-7. PubMed PMID: 21924882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. AU - Oelrich,B, AU - Dewell,A, AU - Gardner,C D, Y1 - 2011/09/15/ PY - 2011/02/28/received PY - 2011/06/16/revised PY - 2011/06/23/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2013/9/10/medline SP - 350 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 4 N2 - BACKGROUND AND AIMS: The well-established triglyceride (TG) lowering effect of fish oil is accompanied by an increase in LDL-cholesterol (LDL-C) concentration. Less is known about the differential impact on LDL particle distribution - the smaller particles being associated with a greater risk for atherosclerosis. We aimed to examine the changes in serum concentrations of four subclasses of LDL particles as well as shifts in LDL phenotype patterns (A, B, AB) among hypertriglyceridemic adults. METHODS AND RESULTS: This was a secondary analysis from a double-blind, parallel design, placebo controlled trial with 42 adults that experienced significant TG lowering and modest increases in total LDL-C concentrations after 12 weeks of 4 g/d EPA + DHA. Reduction in serum TG concentrations (mean ± SEM) was -26 ± 4% (-0.81 ± 10.12 mmol/L), p < 0.0001. Total LDL-C concentration increased by 13 ± 3% (+0.31 ± 0.08 mmol/L), p < 0.0001. The 12-week changes in concentrations of LDL1, LDL2, LDL3 and LDL4 were +0.06 ± 0.02 mmol/L [+2.2 ± 0.7 mg/dL], +0.07 ± 0.03 mmol/L [+2.6 ± 1.0 mg/dL], +0.16 ± 0.05 mmol/L [+6.3 ± 1.8 mg/dL], and +0.04 ± 0.04 mmol/L [+1.4 ± 1.7 mg/dL], respectively (+20 ± 5%, +64 ± 13%, +26 ± 6%, and +17 ± 9%), p < 0.05 for all but LDL4. Changes in LDL phenotype patterns A, B and A/B were negligible and not statistically significant. CONCLUSION: In this population of hypertriglyceridemic adults, dietary supplementation with fish oil resulted in an increase in total LDL-C concentration which was distributed relatively evenly across the range of smaller and more atherogenic as well as larger and less atherogenic LDL particles. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/21924882/Effect_of_fish_oil_supplementation_on_serum_triglycerides_LDL_cholesterol_and_LDL_subfractions_in_hypertriglyceridemic_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(11)00162-1 DB - PRIME DP - Unbound Medicine ER -