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Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats.
Int J Biol Macromol. 2011 Dec 01; 49(5):942-7.IJ

Abstract

This study aimed to evaluate the effect of a polysaccharide named levan, which was produced by new isolated bacteria, on oxidative stress and hyperglycemia in alloxan-induced diabetic rats. Levan polysaccharide was given in drinking water for 60 days at a daily dose equivalent to 2%. The oral administration of levan in diabetic rats caused a decrease in glucose level in plasma and an increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities in both pancreas and liver. Furthermore, a protective action against hepatic and pancreatic toxicity in diabetic rats was clearly observed. Furthermore, a significant decrease in hepatic and pancreatic indices toxicity was observed, i.e., alkalines phosphatases (ALP), aspartate and lactate transaminases (AST and ALT), lactate deshydrogenases (LDH) activities and the thiobarbituric acid-reactive substances (TBARs). These beneficial effects of levan were confirmed by histological findings in hepatic and pancreatic tissues of diabetic rats. This study demonstrates for the first time that levan is efficient in inhibiting hyperglycemia and oxidative stress induced by diabetes and suggests that administration of levan may be helpful in the prevention of diabetic complications associated with oxidative stress.

Authors+Show Affiliations

Biochemistry Laboratory, Faculty of Sciences of Sfax, PB 802, 3018 Sfax, Tunisia. imenbiologie@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21925206

Citation

Dahech, Imen, et al. "Oral Administration of Levan Polysaccharide Reduces the Alloxan-induced Oxidative Stress in Rats." International Journal of Biological Macromolecules, vol. 49, no. 5, 2011, pp. 942-7.
Dahech I, Belghith KS, Hamden K, et al. Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. Int J Biol Macromol. 2011;49(5):942-7.
Dahech, I., Belghith, K. S., Hamden, K., Feki, A., Belghith, H., & Mejdoub, H. (2011). Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. International Journal of Biological Macromolecules, 49(5), 942-7. https://doi.org/10.1016/j.ijbiomac.2011.08.011
Dahech I, et al. Oral Administration of Levan Polysaccharide Reduces the Alloxan-induced Oxidative Stress in Rats. Int J Biol Macromol. 2011 Dec 1;49(5):942-7. PubMed PMID: 21925206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. AU - Dahech,Imen, AU - Belghith,Karima Srih, AU - Hamden,Khaled, AU - Feki,Abdelfattah, AU - Belghith,Hafedh, AU - Mejdoub,Hafedh, Y1 - 2011/09/10/ PY - 2011/07/02/received PY - 2011/07/29/revised PY - 2011/08/11/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2012/2/11/medline SP - 942 EP - 7 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 49 IS - 5 N2 - This study aimed to evaluate the effect of a polysaccharide named levan, which was produced by new isolated bacteria, on oxidative stress and hyperglycemia in alloxan-induced diabetic rats. Levan polysaccharide was given in drinking water for 60 days at a daily dose equivalent to 2%. The oral administration of levan in diabetic rats caused a decrease in glucose level in plasma and an increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities in both pancreas and liver. Furthermore, a protective action against hepatic and pancreatic toxicity in diabetic rats was clearly observed. Furthermore, a significant decrease in hepatic and pancreatic indices toxicity was observed, i.e., alkalines phosphatases (ALP), aspartate and lactate transaminases (AST and ALT), lactate deshydrogenases (LDH) activities and the thiobarbituric acid-reactive substances (TBARs). These beneficial effects of levan were confirmed by histological findings in hepatic and pancreatic tissues of diabetic rats. This study demonstrates for the first time that levan is efficient in inhibiting hyperglycemia and oxidative stress induced by diabetes and suggests that administration of levan may be helpful in the prevention of diabetic complications associated with oxidative stress. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/21925206/Oral_administration_of_levan_polysaccharide_reduces_the_alloxan_induced_oxidative_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(11)00311-4 DB - PRIME DP - Unbound Medicine ER -