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Functional correlation between GABAergic and dopaminergic systems of dorsal hippocampus and ventral tegmental area in passive avoidance learning in rats.
Neuroscience. 2011 Nov 24; 196:104-14.N

Abstract

The aim of the present study was to investigate the existence of possible functional correlation between GABA-A and dopamine (DA) receptors of the dorsal hippocampus and the ventral tegmental area (VTA) in passive avoidance learning. Two guide cannulas were stereotaxically implanted in the CA1 region of the dorsal hippocampus and the VTA of male Wistar rats. In order to measure memory retrieval, the animals were trained in a step-through type passive avoidance task and tested 24 h after training. Post-training intra-CA1 administration of a GABA-A receptor agonist, muscimol (0.01-0.02 μg/rat) dose-dependently impaired memory retrieval. Post-training intra-VTA administration of SCH23390 (a dopamine D1 receptor antagonist; 0.1-0.8 μg/rat) or sulpiride (a D2 receptor antagonist; 0.5-1.5 μg/rat) decreased the inhibitory effect of muscimol (0.02 μg/rat, intra-CA1) on memory retrieval. Intra-VTA administration of the same doses of SCH23390, but not sulpiride, decreased the step-through latencies. On the other hand, post-training administration of muscimol (0.02 μg/rat) into the VTA inhibited memory retrieval. The administration of SCH23390 (0.01-0.2 μg/rat) or sulpiride (0.1-1 μg/rat) into the CA1 region, immediately after training, had no effect on memory retrieval. Furthermore, the amnesic effect of intra-VTA administration of muscimol was significantly decreased by intra-CA1 administration of sulpiride (0.5 and 1 μg/rat, intra-CA1), but not SCH23390. The practical conclusion is that the relationship between the hippocampus and the VTA may regulate memory formation in passive avoidance learning. Also, the correlation between the hippocampus and VTA by a dopaminergic system may be involved in mediating muscimol-induced amnesia.

Authors+Show Affiliations

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21925239

Citation

Nazari-Serenjeh, F, et al. "Functional Correlation Between GABAergic and Dopaminergic Systems of Dorsal Hippocampus and Ventral Tegmental Area in Passive Avoidance Learning in Rats." Neuroscience, vol. 196, 2011, pp. 104-14.
Nazari-Serenjeh F, Rezayof A, Zarrindast MR. Functional correlation between GABAergic and dopaminergic systems of dorsal hippocampus and ventral tegmental area in passive avoidance learning in rats. Neuroscience. 2011;196:104-14.
Nazari-Serenjeh, F., Rezayof, A., & Zarrindast, M. R. (2011). Functional correlation between GABAergic and dopaminergic systems of dorsal hippocampus and ventral tegmental area in passive avoidance learning in rats. Neuroscience, 196, 104-14. https://doi.org/10.1016/j.neuroscience.2011.08.073
Nazari-Serenjeh F, Rezayof A, Zarrindast MR. Functional Correlation Between GABAergic and Dopaminergic Systems of Dorsal Hippocampus and Ventral Tegmental Area in Passive Avoidance Learning in Rats. Neuroscience. 2011 Nov 24;196:104-14. PubMed PMID: 21925239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional correlation between GABAergic and dopaminergic systems of dorsal hippocampus and ventral tegmental area in passive avoidance learning in rats. AU - Nazari-Serenjeh,F, AU - Rezayof,A, AU - Zarrindast,M-R, Y1 - 2011/09/10/ PY - 2011/07/10/received PY - 2011/08/27/revised PY - 2011/08/29/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2012/2/24/medline SP - 104 EP - 14 JF - Neuroscience JO - Neuroscience VL - 196 N2 - The aim of the present study was to investigate the existence of possible functional correlation between GABA-A and dopamine (DA) receptors of the dorsal hippocampus and the ventral tegmental area (VTA) in passive avoidance learning. Two guide cannulas were stereotaxically implanted in the CA1 region of the dorsal hippocampus and the VTA of male Wistar rats. In order to measure memory retrieval, the animals were trained in a step-through type passive avoidance task and tested 24 h after training. Post-training intra-CA1 administration of a GABA-A receptor agonist, muscimol (0.01-0.02 μg/rat) dose-dependently impaired memory retrieval. Post-training intra-VTA administration of SCH23390 (a dopamine D1 receptor antagonist; 0.1-0.8 μg/rat) or sulpiride (a D2 receptor antagonist; 0.5-1.5 μg/rat) decreased the inhibitory effect of muscimol (0.02 μg/rat, intra-CA1) on memory retrieval. Intra-VTA administration of the same doses of SCH23390, but not sulpiride, decreased the step-through latencies. On the other hand, post-training administration of muscimol (0.02 μg/rat) into the VTA inhibited memory retrieval. The administration of SCH23390 (0.01-0.2 μg/rat) or sulpiride (0.1-1 μg/rat) into the CA1 region, immediately after training, had no effect on memory retrieval. Furthermore, the amnesic effect of intra-VTA administration of muscimol was significantly decreased by intra-CA1 administration of sulpiride (0.5 and 1 μg/rat, intra-CA1), but not SCH23390. The practical conclusion is that the relationship between the hippocampus and the VTA may regulate memory formation in passive avoidance learning. Also, the correlation between the hippocampus and VTA by a dopaminergic system may be involved in mediating muscimol-induced amnesia. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/21925239/Functional_correlation_between_GABAergic_and_dopaminergic_systems_of_dorsal_hippocampus_and_ventral_tegmental_area_in_passive_avoidance_learning_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(11)01031-1 DB - PRIME DP - Unbound Medicine ER -