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HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls.
Rheumatol Int. 2012 Oct; 32(10):3103-5.RI

Abstract

The aim of this study was to determine human leukocyte antigen (HLA)-B27 subtypes frequency in ankylosing spondylitis (AS) and related spondyloartropathy (SpA) patients. Therefore, we investigated the differences in HLA-B27 subtypes between HLA-B27-positive patients and controls. Sixty six patients were included in this study (51 AS and 15 SpA). Thirty-five individuals were diagnosed with leukemia or chronic renal failure, and their donors without any rheumatological problem (no SpA history) were selected as the control group. HLA-B27 subtyping was performed by PCR-SSP (polymerase chain reaction with sequence-specific primer) method in serologically HLA-B27-positive 46 AS patients, 9 SpA patients and control group. When the frequency of HLA-B27 was 4.5% in Turkish population, this frequency was 90.2% in AS patients. Four different HLA-B27 subtypes found in AS patients were B 2705 (65.2%), B 2702 (26.1%), B 2704 (6.5%) and B 2707 (2.2%). In SpA patients, B 2705 and B 2702 found in equal frequency. Five B27 alleles were identified in our control group: B 2705 (54.3%), B 2702 (31.4) %, B 2703 (2.9%), B 2704 (2.9%) and B 2702/B 2705 (8.5%). Both in the patient group and in the control group, we also observed B 2705 as most frequent allele, and B 2702 was second common allele. Our results show that the frequency of HLA-B27 subtypes is not significantly different between patients and controls (P > 0.10).

Authors+Show Affiliations

Acar M
Department of Genetics, Selcuk University Medical School, Konya, Turkey. acarmuradiye@hotmail.com
Cora T
No affiliation info available
Tunc R
No affiliation info available
Acar H
No affiliation info available

MeSH

Case-Control StudiesGene FrequencyGenetic Predisposition to DiseaseHLA-B27 AntigenHumansPhenotypePolymerase Chain ReactionSpondylitis, AnkylosingTurkey

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21927904

Citation

Acar, Muradiye, et al. "HLA-B27 Subtypes in Turkish Patients With Ankylosing Spondylitis and Healthy Controls." Rheumatology International, vol. 32, no. 10, 2012, pp. 3103-5.
Acar M, Cora T, Tunc R, et al. HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. Rheumatol Int. 2012;32(10):3103-5.
Acar, M., Cora, T., Tunc, R., & Acar, H. (2012). HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. Rheumatology International, 32(10), 3103-5.
Acar M, et al. HLA-B27 Subtypes in Turkish Patients With Ankylosing Spondylitis and Healthy Controls. Rheumatol Int. 2012;32(10):3103-5. PubMed PMID: 21927904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-B27 subtypes in Turkish patients with ankylosing spondylitis and healthy controls. AU - Acar,Muradiye, AU - Cora,Tulin, AU - Tunc,Recep, AU - Acar,Hasan, Y1 - 2011/09/17/ PY - 2011/03/23/received PY - 2011/08/21/accepted PY - 2011/9/20/entrez PY - 2011/9/20/pubmed PY - 2013/2/21/medline SP - 3103 EP - 5 JF - Rheumatology international JO - Rheumatol Int VL - 32 IS - 10 N2 - The aim of this study was to determine human leukocyte antigen (HLA)-B27 subtypes frequency in ankylosing spondylitis (AS) and related spondyloartropathy (SpA) patients. Therefore, we investigated the differences in HLA-B27 subtypes between HLA-B27-positive patients and controls. Sixty six patients were included in this study (51 AS and 15 SpA). Thirty-five individuals were diagnosed with leukemia or chronic renal failure, and their donors without any rheumatological problem (no SpA history) were selected as the control group. HLA-B27 subtyping was performed by PCR-SSP (polymerase chain reaction with sequence-specific primer) method in serologically HLA-B27-positive 46 AS patients, 9 SpA patients and control group. When the frequency of HLA-B27 was 4.5% in Turkish population, this frequency was 90.2% in AS patients. Four different HLA-B27 subtypes found in AS patients were B 2705 (65.2%), B 2702 (26.1%), B 2704 (6.5%) and B 2707 (2.2%). In SpA patients, B 2705 and B 2702 found in equal frequency. Five B27 alleles were identified in our control group: B 2705 (54.3%), B 2702 (31.4) %, B 2703 (2.9%), B 2704 (2.9%) and B 2702/B 2705 (8.5%). Both in the patient group and in the control group, we also observed B 2705 as most frequent allele, and B 2702 was second common allele. Our results show that the frequency of HLA-B27 subtypes is not significantly different between patients and controls (P > 0.10). SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/21927904/HLA_B27_subtypes_in_Turkish_patients_with_ankylosing_spondylitis_and_healthy_controls_ L2 - https://dx.doi.org/10.1007/s00296-011-2099-0 DB - PRIME DP - Unbound Medicine ER -