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Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle marmelos (Linn.).
Acta Pol Pharm. 2011 Sep-Oct; 68(5):687-92.AP

Abstract

The in vitro antimicrobial activity of serial petroleum ether, chloroform and methanol extracts from leaves of Aegle mawmelos were investigated against bacterial and fungal species. All the extracts exhibited broad spectrum antimicrobial activity with zones of inhibition ranging from 10 to 22 mm against bacteria: Staphylococcus aureus, beta Streptococcus haemolyticus group A, Proteus mimrabilis, Klebsiella pneumoniae, Pseudomonas aenrginosa, Escherichia coli, Salmonella typhi, fungi: Candida albicans, Candida tropicalis and Aspergillusflavus. The minimal inhibitory concentrations (MIC) and the minimal microbicidal concentrations (MMC) of the extracts ranged from 1.25 to 10 mg/mL and 2.5 to 20 mg/mL respectively. Assessment of antibacterial efficacy of different extract revealed that Staphylococcus aureus, beta Streptococcus haemolyticus group A, Pseudomonas aeruginosa and Escherichia coli showed high susceptibility to petroleum ether extract. Proteus mimrabilis, Klebsiella pneumoniae showed high susceptibility to chloroform extract and Salmonella typhi showed high susceptibility to methanol extract. Petroleum ether extract exhibited the highest antifungal efficacy against all tested fungal species. Phytochemical screening revealed the presence of phenols, sterols in petroleum ether and chloroform extracts, whereas tannins, flavonoids, coumarins, saponins and triterpenoids in methanol extract. The ability of the leaf extracts of Aegle manmelos to inhibit growth of bacteria and fungi is an indication of its broad spectrum antimicrobial activity which could be a potential source for development of novel bioactive antimicrobial agents.

Authors+Show Affiliations

Department of Pharmacology, Gajara Raja Medical College, Gwalior, (M.P.), India. saroj.kothari@rediff.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21928713

Citation

Kothari, Saroj, et al. "Antimicrobial Activity and Phytochemical Screening of Serial Extracts From Leaves of Aegle Marmelos (Linn.)." Acta Poloniae Pharmaceutica, vol. 68, no. 5, 2011, pp. 687-92.
Kothari S, Mishra V, Bharat S, et al. Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle marmelos (Linn.). Acta Pol Pharm. 2011;68(5):687-92.
Kothari, S., Mishra, V., Bharat, S., & Tonpay, S. D. (2011). Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle marmelos (Linn.). Acta Poloniae Pharmaceutica, 68(5), 687-92.
Kothari S, et al. Antimicrobial Activity and Phytochemical Screening of Serial Extracts From Leaves of Aegle Marmelos (Linn.). Acta Pol Pharm. 2011 Sep-Oct;68(5):687-92. PubMed PMID: 21928713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial activity and phytochemical screening of serial extracts from leaves of Aegle marmelos (Linn.). AU - Kothari,Saroj, AU - Mishra,Vaibhav, AU - Bharat,Savita, AU - Tonpay,Shrinivas D, PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2011/10/14/medline SP - 687 EP - 92 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 68 IS - 5 N2 - The in vitro antimicrobial activity of serial petroleum ether, chloroform and methanol extracts from leaves of Aegle mawmelos were investigated against bacterial and fungal species. All the extracts exhibited broad spectrum antimicrobial activity with zones of inhibition ranging from 10 to 22 mm against bacteria: Staphylococcus aureus, beta Streptococcus haemolyticus group A, Proteus mimrabilis, Klebsiella pneumoniae, Pseudomonas aenrginosa, Escherichia coli, Salmonella typhi, fungi: Candida albicans, Candida tropicalis and Aspergillusflavus. The minimal inhibitory concentrations (MIC) and the minimal microbicidal concentrations (MMC) of the extracts ranged from 1.25 to 10 mg/mL and 2.5 to 20 mg/mL respectively. Assessment of antibacterial efficacy of different extract revealed that Staphylococcus aureus, beta Streptococcus haemolyticus group A, Pseudomonas aeruginosa and Escherichia coli showed high susceptibility to petroleum ether extract. Proteus mimrabilis, Klebsiella pneumoniae showed high susceptibility to chloroform extract and Salmonella typhi showed high susceptibility to methanol extract. Petroleum ether extract exhibited the highest antifungal efficacy against all tested fungal species. Phytochemical screening revealed the presence of phenols, sterols in petroleum ether and chloroform extracts, whereas tannins, flavonoids, coumarins, saponins and triterpenoids in methanol extract. The ability of the leaf extracts of Aegle manmelos to inhibit growth of bacteria and fungi is an indication of its broad spectrum antimicrobial activity which could be a potential source for development of novel bioactive antimicrobial agents. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/21928713/Antimicrobial_activity_and_phytochemical_screening_of_serial_extracts_from_leaves_of_Aegle_marmelos__Linn___ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2011/5/687.pdf DB - PRIME DP - Unbound Medicine ER -