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Regulation of the receptor-mediated cyclic AMP response of kidney to parathyroid hormone in the vitamin D-deficient rat.
J Supramol Struct. 1978; 9(2):179-88.JS

Abstract

Rats fed a diet deficient in vitamin D were found to exhibit a refractory cyclic AMP response of kidney slices to parathyroid hormone and a marked decrease in membrane parathyroid hormone-dependent adenylate cyclase activity. Both the characteristic calcium deficiency (hypocalcemia) and secondary elevation of circulating parathyroid hormone appeared before the first noticeable decrease in hormone-dependent enzyme activity. After repletion of D-deficient rats with vitamin D2, we found that serum calcium and parathyroid hormone were both restored to normal levels before the depressed enzyme response to the hormone was reversed. Moreover, infusion of parthyroid hormone into vitamin D-replete rats led to a marked reduction in parathyroid hormone-dependent adenylate cyclase activity, which was partly restored to control level 3 hours after discontinuing the hormone infusion. Taken as a whole, this study suggests that the elevated endogenous parathyroid hormone in the vitamin D-deficient rat is involved in the "down-regulation" of renal cyclic AMP responsiveness to the hormone. However, these experiments do not rule out the possibility that calcium deficiency and/or vitamin D per se participate in the regulation of the renal cyclic AMP response to parathyroid hormone.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

219292

Citation

Forte, L R., et al. "Regulation of the Receptor-mediated Cyclic AMP Response of Kidney to Parathyroid Hormone in the Vitamin D-deficient Rat." Journal of Supramolecular Structure, vol. 9, no. 2, 1978, pp. 179-88.
Forte LR, Carnes DL, Nickols GA, et al. Regulation of the receptor-mediated cyclic AMP response of kidney to parathyroid hormone in the vitamin D-deficient rat. J Supramol Struct. 1978;9(2):179-88.
Forte, L. R., Carnes, D. L., Nickols, G. A., & Anast, C. S. (1978). Regulation of the receptor-mediated cyclic AMP response of kidney to parathyroid hormone in the vitamin D-deficient rat. Journal of Supramolecular Structure, 9(2), 179-88.
Forte LR, et al. Regulation of the Receptor-mediated Cyclic AMP Response of Kidney to Parathyroid Hormone in the Vitamin D-deficient Rat. J Supramol Struct. 1978;9(2):179-88. PubMed PMID: 219292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of the receptor-mediated cyclic AMP response of kidney to parathyroid hormone in the vitamin D-deficient rat. AU - Forte,L R, AU - Carnes,D L, AU - Nickols,G A, AU - Anast,C S, PY - 1978/1/1/pubmed PY - 1978/1/1/medline PY - 1978/1/1/entrez SP - 179 EP - 88 JF - Journal of supramolecular structure JO - J. Supramol. Struct. VL - 9 IS - 2 N2 - Rats fed a diet deficient in vitamin D were found to exhibit a refractory cyclic AMP response of kidney slices to parathyroid hormone and a marked decrease in membrane parathyroid hormone-dependent adenylate cyclase activity. Both the characteristic calcium deficiency (hypocalcemia) and secondary elevation of circulating parathyroid hormone appeared before the first noticeable decrease in hormone-dependent enzyme activity. After repletion of D-deficient rats with vitamin D2, we found that serum calcium and parathyroid hormone were both restored to normal levels before the depressed enzyme response to the hormone was reversed. Moreover, infusion of parthyroid hormone into vitamin D-replete rats led to a marked reduction in parathyroid hormone-dependent adenylate cyclase activity, which was partly restored to control level 3 hours after discontinuing the hormone infusion. Taken as a whole, this study suggests that the elevated endogenous parathyroid hormone in the vitamin D-deficient rat is involved in the "down-regulation" of renal cyclic AMP responsiveness to the hormone. However, these experiments do not rule out the possibility that calcium deficiency and/or vitamin D per se participate in the regulation of the renal cyclic AMP response to parathyroid hormone. SN - 0091-7419 UR - https://www.unboundmedicine.com/medline/citation/219292/Regulation_of_the_receptor_mediated_cyclic_AMP_response_of_kidney_to_parathyroid_hormone_in_the_vitamin_D_deficient_rat_ L2 - https://medlineplus.gov/vitaminddeficiency.html DB - PRIME DP - Unbound Medicine ER -