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Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring.
Pediatr Allergy Immunol. 2011 Dec; 22(8):827-35.PA

Abstract

BACKGROUND

Fatty acids (FA) modulate the immune system, and it has been proposed that they affect the incidence of IgE-mediated allergic diseases. We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring.

METHODS

We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Maternal dietary intake during pregnancy (8th month) was assessed by a validated 181-item food frequency questionnaire. The occurrence of asthma was assessed at the age of 5 yr with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for the statistical analyses.

RESULTS

Low maternal intakes of α-linolenic acid (18:3n-3) [lowest quarter vs. mid-half HR 1.67 (95% CI 1.12-2.48)] and total n-3-polyunsaturated fatty acids (PUFA) [HR 1.66 (95% CI 1.11-2.48)] during pregnancy were associated with an increased risk of asthma in the offspring, while a low intake of arachidonic acid (20:4n-6) [HR 0.52 (95% CI 0.32-0.84)] and high intake of total saturated fatty acids [highest quarter vs. mid-half HR 0.55 (95% CI 0.34-0.90)] and palmitic acid (16:0) [HR 0.51 (95% CI 0.31-0.83)] were associated with a decreased risk of asthma. The ratios of n-6 to n-3-PUFA and 18:2n-6 to 18:3n-3, and the maternal intake of oils, fish and fish products, showed no association with the risk of asthma. The associations found were independent of several perinatal and clinical confounders.

CONCLUSION

Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal α-linolenic acid, total n-3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring.

Authors+Show Affiliations

Nutrition Unit, Department of Lifestyle and Participation, National Institute of Health and Welfare, Helsinki, Finland. mirka.lumia@fimnet.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21929596

Citation

Lumia, Mirka, et al. "Dietary Fatty Acid Composition During Pregnancy and the Risk of Asthma in the Offspring." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 22, no. 8, 2011, pp. 827-35.
Lumia M, Luukkainen P, Tapanainen H, et al. Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatr Allergy Immunol. 2011;22(8):827-35.
Lumia, M., Luukkainen, P., Tapanainen, H., Kaila, M., Erkkola, M., Uusitalo, L., Niinistö, S., Kenward, M. G., Ilonen, J., Simell, O., Knip, M., Veijola, R., & Virtanen, S. M. (2011). Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 22(8), 827-35. https://doi.org/10.1111/j.1399-3038.2011.01202.x
Lumia M, et al. Dietary Fatty Acid Composition During Pregnancy and the Risk of Asthma in the Offspring. Pediatr Allergy Immunol. 2011;22(8):827-35. PubMed PMID: 21929596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. AU - Lumia,Mirka, AU - Luukkainen,Päivi, AU - Tapanainen,Heli, AU - Kaila,Minna, AU - Erkkola,Maijaliisa, AU - Uusitalo,Liisa, AU - Niinistö,Sari, AU - Kenward,Michael G, AU - Ilonen,Jorma, AU - Simell,Olli, AU - Knip,Mikael, AU - Veijola,Riitta, AU - Virtanen,Suvi M, Y1 - 2011/09/19/ PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2012/4/7/medline SP - 827 EP - 35 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 22 IS - 8 N2 - BACKGROUND: Fatty acids (FA) modulate the immune system, and it has been proposed that they affect the incidence of IgE-mediated allergic diseases. We explored the association of maternal dietary FA composition during pregnancy with the risk of asthma in the offspring. METHODS: We analyzed data from the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. Maternal dietary intake during pregnancy (8th month) was assessed by a validated 181-item food frequency questionnaire. The occurrence of asthma was assessed at the age of 5 yr with a questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC). Cox proportional hazards regression was used for the statistical analyses. RESULTS: Low maternal intakes of α-linolenic acid (18:3n-3) [lowest quarter vs. mid-half HR 1.67 (95% CI 1.12-2.48)] and total n-3-polyunsaturated fatty acids (PUFA) [HR 1.66 (95% CI 1.11-2.48)] during pregnancy were associated with an increased risk of asthma in the offspring, while a low intake of arachidonic acid (20:4n-6) [HR 0.52 (95% CI 0.32-0.84)] and high intake of total saturated fatty acids [highest quarter vs. mid-half HR 0.55 (95% CI 0.34-0.90)] and palmitic acid (16:0) [HR 0.51 (95% CI 0.31-0.83)] were associated with a decreased risk of asthma. The ratios of n-6 to n-3-PUFA and 18:2n-6 to 18:3n-3, and the maternal intake of oils, fish and fish products, showed no association with the risk of asthma. The associations found were independent of several perinatal and clinical confounders. CONCLUSION: Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal α-linolenic acid, total n-3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring. SN - 1399-3038 UR - https://www.unboundmedicine.com/medline/citation/21929596/Dietary_fatty_acid_composition_during_pregnancy_and_the_risk_of_asthma_in_the_offspring_ L2 - https://doi.org/10.1111/j.1399-3038.2011.01202.x DB - PRIME DP - Unbound Medicine ER -