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Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects.
Br J Nutr 2012; 107(10):1445-51BJ

Abstract

Berries are often consumed with sucrose. They are also rich sources of polyphenols which may modulate glycaemia after carbohydrate ingestion. The present study investigated the postprandial glucose, insulin and glucagon-like peptide 1 (GLP-1) responses to sucrose ingested with berries, in comparison with a similar sucrose load without berries. A total of twelve healthy subjects were recruited to a randomised, single-blind, placebo-controlled crossover study. They participated in two meal tests on separate days. The berry meal was a purée (150 g) made of bilberries, blackcurrants, cranberries and strawberries with 35 g sucrose. The control meal included the same amount of sucrose and available carbohydrates in water. Fingertip capillary and venous blood samples were taken at baseline and at 15, 30, 45, 60, 90 and 120 min after starting to eat the meal. Glucose, insulin and GLP-1 concentrations were determined from the venous samples, and glucose also from the capillary samples. Compared to the control meal, ingestion of the berry meal resulted in lower capillary and venous plasma glucose and serum insulin concentrations at 15 min (P = 0·021, P < 0·007 and P = 0·028, respectively), in higher concentrations at 90 min (P = 0·028, P = 0·021 and P = 0·042, respectively), and in a modest effect on the GLP-1 response (P = 0·05). It also reduced the maximum increases of capillary and venous glucose and insulin concentrations (P = 0·009, P = 0·011 and P = 0·005, respectively), and improved the glycaemic profile (P < 0·001 and P = 0·003 for capillary and venous samples, respectively). These results suggest that the glycaemic control after ingestion of sucrose can be improved by simultaneous consumption of berries.

Authors+Show Affiliations

Department of Clinical Nutrition, Food and Health Research Centre, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland. riitta.torronen@uef.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21929838

Citation

Törrönen, Riitta, et al. "Postprandial Glucose, Insulin and Glucagon-like Peptide 1 Responses to Sucrose Ingested With Berries in Healthy Subjects." The British Journal of Nutrition, vol. 107, no. 10, 2012, pp. 1445-51.
Törrönen R, Sarkkinen E, Niskanen T, et al. Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. Br J Nutr. 2012;107(10):1445-51.
Törrönen, R., Sarkkinen, E., Niskanen, T., Tapola, N., Kilpi, K., & Niskanen, L. (2012). Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. The British Journal of Nutrition, 107(10), pp. 1445-51. doi:10.1017/S0007114511004557.
Törrönen R, et al. Postprandial Glucose, Insulin and Glucagon-like Peptide 1 Responses to Sucrose Ingested With Berries in Healthy Subjects. Br J Nutr. 2012;107(10):1445-51. PubMed PMID: 21929838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. AU - Törrönen,Riitta, AU - Sarkkinen,Essi, AU - Niskanen,Tarja, AU - Tapola,Niina, AU - Kilpi,Kyllikki, AU - Niskanen,Leo, Y1 - 2011/09/20/ PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2012/7/11/medline SP - 1445 EP - 51 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 107 IS - 10 N2 - Berries are often consumed with sucrose. They are also rich sources of polyphenols which may modulate glycaemia after carbohydrate ingestion. The present study investigated the postprandial glucose, insulin and glucagon-like peptide 1 (GLP-1) responses to sucrose ingested with berries, in comparison with a similar sucrose load without berries. A total of twelve healthy subjects were recruited to a randomised, single-blind, placebo-controlled crossover study. They participated in two meal tests on separate days. The berry meal was a purée (150 g) made of bilberries, blackcurrants, cranberries and strawberries with 35 g sucrose. The control meal included the same amount of sucrose and available carbohydrates in water. Fingertip capillary and venous blood samples were taken at baseline and at 15, 30, 45, 60, 90 and 120 min after starting to eat the meal. Glucose, insulin and GLP-1 concentrations were determined from the venous samples, and glucose also from the capillary samples. Compared to the control meal, ingestion of the berry meal resulted in lower capillary and venous plasma glucose and serum insulin concentrations at 15 min (P = 0·021, P < 0·007 and P = 0·028, respectively), in higher concentrations at 90 min (P = 0·028, P = 0·021 and P = 0·042, respectively), and in a modest effect on the GLP-1 response (P = 0·05). It also reduced the maximum increases of capillary and venous glucose and insulin concentrations (P = 0·009, P = 0·011 and P = 0·005, respectively), and improved the glycaemic profile (P < 0·001 and P = 0·003 for capillary and venous samples, respectively). These results suggest that the glycaemic control after ingestion of sucrose can be improved by simultaneous consumption of berries. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21929838/Postprandial_glucose_insulin_and_glucagon_like_peptide_1_responses_to_sucrose_ingested_with_berries_in_healthy_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511004557/type/journal_article DB - PRIME DP - Unbound Medicine ER -