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Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity.
Food Chem Toxicol. 2011 Dec; 49(12):3090-7.FC

Abstract

Nephrotoxicity is one of the serious dose limiting side effects of cisplatin when used in the treatment of various malignant conditions. Accumulating evidence suggests that oxidative stress caused by free radicals and apoptosis of renal cells contributes to the pathogenesis of cisplatin-induced nephrotoxicity. Present study was aimed to explore the effect of carnosic acid, a potent antioxidant, against cisplatin induced oxidative stress and nephrotoxicity in rats. A single dose of cisplatin (7.5mg/kg) caused marked renal damage, characterized by a significant (P<0.05) increase in serum creatinine, blood urea nitrogen (BUN) and relative weight of kidney with higher kidney MDA (malondialdehyde), tROS (total reactive oxygen species), caspase 3, GSH (reduced glutathione) levels and lowered tissue nitrite, SOD (superoxide dismutase), CAT (catalase), GSH-Px (glutathione peroxidase), GR (glutathione reductase) and GST (glutathione S-transferase) levels compared to normal control. Carnosic acid treatment significantly (P<0.05) attenuated the increase in lipid peroxidation, caspase-3 and ROS generation and enhanced the levels of reduced glutathione, tissue nitrite level and activities of SOD, CAT, GSH-Px, GR and GST compared to cisplatin control. The present study demonstrates that carnosic acid has a protective effect on cisplatin induced experimental nephrotoxicity and is attributed to its potent antioxidant and antiapoptotic properties.

Authors+Show Affiliations

National Institute of Pharmaceutical Education and Research, Balanagar, Hyderabad, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21930180

Citation

Sahu, Bidya Dhar, et al. "Carnosic Acid Attenuates Renal Injury in an Experimental Model of Rat Cisplatin-induced Nephrotoxicity." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 49, no. 12, 2011, pp. 3090-7.
Sahu BD, Rentam KK, Putcha UK, et al. Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. Food Chem Toxicol. 2011;49(12):3090-7.
Sahu, B. D., Rentam, K. K., Putcha, U. K., Kuncha, M., Vegi, G. M., & Sistla, R. (2011). Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 49(12), 3090-7. https://doi.org/10.1016/j.fct.2011.08.018
Sahu BD, et al. Carnosic Acid Attenuates Renal Injury in an Experimental Model of Rat Cisplatin-induced Nephrotoxicity. Food Chem Toxicol. 2011;49(12):3090-7. PubMed PMID: 21930180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity. AU - Sahu,Bidya Dhar, AU - Rentam,Kiran Kumar Reddy, AU - Putcha,Uday Kumar, AU - Kuncha,Madhusudana, AU - Vegi,Ganga Modi Naidu, AU - Sistla,Ramakrishna, Y1 - 2011/09/06/ PY - 2011/07/21/received PY - 2011/08/12/revised PY - 2011/08/18/accepted PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2012/3/29/medline SP - 3090 EP - 7 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 49 IS - 12 N2 - Nephrotoxicity is one of the serious dose limiting side effects of cisplatin when used in the treatment of various malignant conditions. Accumulating evidence suggests that oxidative stress caused by free radicals and apoptosis of renal cells contributes to the pathogenesis of cisplatin-induced nephrotoxicity. Present study was aimed to explore the effect of carnosic acid, a potent antioxidant, against cisplatin induced oxidative stress and nephrotoxicity in rats. A single dose of cisplatin (7.5mg/kg) caused marked renal damage, characterized by a significant (P<0.05) increase in serum creatinine, blood urea nitrogen (BUN) and relative weight of kidney with higher kidney MDA (malondialdehyde), tROS (total reactive oxygen species), caspase 3, GSH (reduced glutathione) levels and lowered tissue nitrite, SOD (superoxide dismutase), CAT (catalase), GSH-Px (glutathione peroxidase), GR (glutathione reductase) and GST (glutathione S-transferase) levels compared to normal control. Carnosic acid treatment significantly (P<0.05) attenuated the increase in lipid peroxidation, caspase-3 and ROS generation and enhanced the levels of reduced glutathione, tissue nitrite level and activities of SOD, CAT, GSH-Px, GR and GST compared to cisplatin control. The present study demonstrates that carnosic acid has a protective effect on cisplatin induced experimental nephrotoxicity and is attributed to its potent antioxidant and antiapoptotic properties. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/21930180/Carnosic_acid_attenuates_renal_injury_in_an_experimental_model_of_rat_cisplatin_induced_nephrotoxicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00435-2 DB - PRIME DP - Unbound Medicine ER -