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Seasonal, gestational and postnatal influences on multiple sclerosis: the beneficial role of a vitamin D supplementation during early life.

Abstract

There is now strong evidence linking vitamin D, the steroid hormone of sunlight, and Multiple Sclerosis (MS). Two of the most intriguing findings are the season of birth and childhood sun exposure effects. They both suggest that a vitamin D deficiency during these critical imprinting periods is a risk factor for MS. After having confirmed that people born in November are at lower risk of developing MS, we devised a mouse model of prenatal vitamin D deficiency. We observed that adult offspring born to vitamin D deficient mothers, when compared to control offspring, developed a striking milder and delayed experimental autoimmune encephalomyelitis (EAE) and permanently overexpressed the vitamin D receptor. This unexpected finding led us to conjecture that the newborns, after having known an in utero vitamin D-deficient environment, were highly sensitive ex utero to cholecalciferol-containing diet and interpreted the postnatal food as a vitamin D enriched environment. To validate this hypothesis, we devised a mouse model of postnatal vitamin D supplementation. Interestingly, using the same EAE model, we demonstrated that a delayed onset and less severe symptoms were displayed by postnatally vitamin D-supplemented mice. The latter finding is in accordance with previous animal studies demonstrating that a postnatal vitamin D deficiency induced an earlier onset and an increased symptom severity of EAE and epidemiological reports describing the importance of an adequate supply of vitamin D during early life.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Aix-Marseille Univ, NICN, CNRS UMR 6184, 13015 Marseille, France.

    ,

    Source

    Journal of the neurological sciences 311:1-2 2011 Dec 15 pg 64-8

    MeSH

    Animals
    Animals, Newborn
    Dietary Supplements
    Disease Models, Animal
    Female
    Humans
    Infant, Newborn
    Mice
    Multiple Sclerosis
    Pregnancy
    Risk Factors
    Seasons
    Treatment Outcome
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21930286

    Citation

    Fernandes de Abreu, Diana A., et al. "Seasonal, Gestational and Postnatal Influences On Multiple Sclerosis: the Beneficial Role of a Vitamin D Supplementation During Early Life." Journal of the Neurological Sciences, vol. 311, no. 1-2, 2011, pp. 64-8.
    Fernandes de Abreu DA, Landel V, Féron F. Seasonal, gestational and postnatal influences on multiple sclerosis: the beneficial role of a vitamin D supplementation during early life. J Neurol Sci. 2011;311(1-2):64-8.
    Fernandes de Abreu, D. A., Landel, V., & Féron, F. (2011). Seasonal, gestational and postnatal influences on multiple sclerosis: the beneficial role of a vitamin D supplementation during early life. Journal of the Neurological Sciences, 311(1-2), pp. 64-8. doi:10.1016/j.jns.2011.08.044.
    Fernandes de Abreu DA, Landel V, Féron F. Seasonal, Gestational and Postnatal Influences On Multiple Sclerosis: the Beneficial Role of a Vitamin D Supplementation During Early Life. J Neurol Sci. 2011 Dec 15;311(1-2):64-8. PubMed PMID: 21930286.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Seasonal, gestational and postnatal influences on multiple sclerosis: the beneficial role of a vitamin D supplementation during early life. AU - Fernandes de Abreu,Diana A, AU - Landel,Véréna, AU - Féron,François, Y1 - 2011/09/17/ PY - 2011/04/29/received PY - 2011/08/23/revised PY - 2011/08/29/accepted PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2012/9/1/medline SP - 64 EP - 8 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 311 IS - 1-2 N2 - There is now strong evidence linking vitamin D, the steroid hormone of sunlight, and Multiple Sclerosis (MS). Two of the most intriguing findings are the season of birth and childhood sun exposure effects. They both suggest that a vitamin D deficiency during these critical imprinting periods is a risk factor for MS. After having confirmed that people born in November are at lower risk of developing MS, we devised a mouse model of prenatal vitamin D deficiency. We observed that adult offspring born to vitamin D deficient mothers, when compared to control offspring, developed a striking milder and delayed experimental autoimmune encephalomyelitis (EAE) and permanently overexpressed the vitamin D receptor. This unexpected finding led us to conjecture that the newborns, after having known an in utero vitamin D-deficient environment, were highly sensitive ex utero to cholecalciferol-containing diet and interpreted the postnatal food as a vitamin D enriched environment. To validate this hypothesis, we devised a mouse model of postnatal vitamin D supplementation. Interestingly, using the same EAE model, we demonstrated that a delayed onset and less severe symptoms were displayed by postnatally vitamin D-supplemented mice. The latter finding is in accordance with previous animal studies demonstrating that a postnatal vitamin D deficiency induced an earlier onset and an increased symptom severity of EAE and epidemiological reports describing the importance of an adequate supply of vitamin D during early life. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/21930286/Seasonal_gestational_and_postnatal_influences_on_multiple_sclerosis:_the_beneficial_role_of_a_vitamin_D_supplementation_during_early_life_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(11)00541-7 DB - PRIME DP - Unbound Medicine ER -