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Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials.
Nutr Metab Cardiovasc Dis 2011; 21(11):844-50NM

Abstract

AIMS

Human clinical studies have yielded mixed results on the effects of consumption of probiotics on the plasma lipid profile. We conducted a meta-analysis of randomised controlled trials that evaluated the effects of probiotics consumption on blood lipids.

DATA SYNTHESIS

A systematic literature search of Embase, Web of Science, PubMed and Cochrane Controlled Trials Registry was conducted for studies that investigated the efficacy of probiotics on the plasma lipid profile of subjects. With the help of Review Manager 4.2, data from 13 trials, which included 485 participants with high, borderline high and normal cholesterol levels, were examined. The pooled mean net change in total cholesterol for those treated with probiotics compared to controls was -6.40 mg dl(-1) (95% confidence interval (CI), -9.93 to -2.87), mean net change in low-density lipoprotein (LDL) cholesterol was -4.90 mg dl(-1) (95% CI, -7.91 to -1.90), mean net change in high-density lipoprotein (HDL) cholesterol was -0.11 mg dl(-1) (95% CI, -1.90-1.69) and mean net change in triglycerides was -3.95 mg dl(-1) (95% CI, -10.32-2.42).

CONCLUSION

These results indicate that a diet rich in probiotics decreases total cholesterol and LDL cholesterol concentration in plasma for participants with high, borderline high and normal cholesterol levels.

Authors+Show Affiliations

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21930366

Citation

Guo, Z, et al. "Influence of Consumption of Probiotics On the Plasma Lipid Profile: a Meta-analysis of Randomised Controlled Trials." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 21, no. 11, 2011, pp. 844-50.
Guo Z, Liu XM, Zhang QX, et al. Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. Nutr Metab Cardiovasc Dis. 2011;21(11):844-50.
Guo, Z., Liu, X. M., Zhang, Q. X., Shen, Z., Tian, F. W., Zhang, H., ... Chen, W. (2011). Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 21(11), pp. 844-50. doi:10.1016/j.numecd.2011.04.008.
Guo Z, et al. Influence of Consumption of Probiotics On the Plasma Lipid Profile: a Meta-analysis of Randomised Controlled Trials. Nutr Metab Cardiovasc Dis. 2011;21(11):844-50. PubMed PMID: 21930366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. AU - Guo,Z, AU - Liu,X M, AU - Zhang,Q X, AU - Shen,Z, AU - Tian,F W, AU - Zhang,H, AU - Sun,Z H, AU - Zhang,H P, AU - Chen,W, Y1 - 2011/09/17/ PY - 2010/12/03/received PY - 2011/04/06/revised PY - 2011/04/07/accepted PY - 2011/9/21/entrez PY - 2011/9/21/pubmed PY - 2012/2/3/medline SP - 844 EP - 50 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 21 IS - 11 N2 - AIMS: Human clinical studies have yielded mixed results on the effects of consumption of probiotics on the plasma lipid profile. We conducted a meta-analysis of randomised controlled trials that evaluated the effects of probiotics consumption on blood lipids. DATA SYNTHESIS: A systematic literature search of Embase, Web of Science, PubMed and Cochrane Controlled Trials Registry was conducted for studies that investigated the efficacy of probiotics on the plasma lipid profile of subjects. With the help of Review Manager 4.2, data from 13 trials, which included 485 participants with high, borderline high and normal cholesterol levels, were examined. The pooled mean net change in total cholesterol for those treated with probiotics compared to controls was -6.40 mg dl(-1) (95% confidence interval (CI), -9.93 to -2.87), mean net change in low-density lipoprotein (LDL) cholesterol was -4.90 mg dl(-1) (95% CI, -7.91 to -1.90), mean net change in high-density lipoprotein (HDL) cholesterol was -0.11 mg dl(-1) (95% CI, -1.90-1.69) and mean net change in triglycerides was -3.95 mg dl(-1) (95% CI, -10.32-2.42). CONCLUSION: These results indicate that a diet rich in probiotics decreases total cholesterol and LDL cholesterol concentration in plasma for participants with high, borderline high and normal cholesterol levels. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/21930366/Influence_of_consumption_of_probiotics_on_the_plasma_lipid_profile:_a_meta_analysis_of_randomised_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(11)00103-7 DB - PRIME DP - Unbound Medicine ER -