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Serological markers and celiac disease: a new diagnostic approach?
J Pediatr Gastroenterol Nutr. 1990 May; 10(4):435-42.JP

Abstract

We analyze the diagnostic efficacy of two celiac disease serological markers: anti-gliadin (IgA and IgG class) and anti-endomysium IgA-class (EmA-IgA) antibodies applied to 336 serum samples from celiac patients on both gluten-challenge and gluten-free diets, and a control group. The anti-gliadin and anti-endomysium antibodies levels were significantly higher among the gluten-consuming celiac patients than in the other groups. The greatest efficacy in diagnosing celiac disease was achieved in the Ema-IgA class test. The IgA-class anti-gliadin antibodies proved to be more specific, with a higher positive test predictive value than the IgG-class anti-gliadin antibodies, whereas the latter proved to be more sensitive, with a higher negative test predictive value than those of the IgA-class anti-gliadin antibodies. Our results also demonstrate that the simultaneous assessment of anti-gliadin IgA- and IgG-class antibodies constitutes a valid test in selecting patients suspected of having celiac disease. In turn the EmA-IgA antibodies constitute a confirmative test for indication of an intestinal biopsy.

Authors+Show Affiliations

General Hospital, Department of Pediatrics and Clinical Analysis Section of Gastroenterology, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2193137

Citation

Calabuig, M, et al. "Serological Markers and Celiac Disease: a New Diagnostic Approach?" Journal of Pediatric Gastroenterology and Nutrition, vol. 10, no. 4, 1990, pp. 435-42.
Calabuig M, Torregosa R, Polo P, et al. Serological markers and celiac disease: a new diagnostic approach? J Pediatr Gastroenterol Nutr. 1990;10(4):435-42.
Calabuig, M., Torregosa, R., Polo, P., Tuset, L., Tomás, C., Alvarez, V., Garcia-Vila, A., Brines, J., Vilar, P., & Farré, C. (1990). Serological markers and celiac disease: a new diagnostic approach? Journal of Pediatric Gastroenterology and Nutrition, 10(4), 435-42.
Calabuig M, et al. Serological Markers and Celiac Disease: a New Diagnostic Approach. J Pediatr Gastroenterol Nutr. 1990;10(4):435-42. PubMed PMID: 2193137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological markers and celiac disease: a new diagnostic approach? A1 - Calabuig,M, AU - Torregosa,R, AU - Polo,P, AU - Tuset,L, AU - Tomás,C, AU - Alvarez,V, AU - Garcia-Vila,A, AU - Brines,J, AU - Vilar,P, AU - Farré,C, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 435 EP - 42 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 10 IS - 4 N2 - We analyze the diagnostic efficacy of two celiac disease serological markers: anti-gliadin (IgA and IgG class) and anti-endomysium IgA-class (EmA-IgA) antibodies applied to 336 serum samples from celiac patients on both gluten-challenge and gluten-free diets, and a control group. The anti-gliadin and anti-endomysium antibodies levels were significantly higher among the gluten-consuming celiac patients than in the other groups. The greatest efficacy in diagnosing celiac disease was achieved in the Ema-IgA class test. The IgA-class anti-gliadin antibodies proved to be more specific, with a higher positive test predictive value than the IgG-class anti-gliadin antibodies, whereas the latter proved to be more sensitive, with a higher negative test predictive value than those of the IgA-class anti-gliadin antibodies. Our results also demonstrate that the simultaneous assessment of anti-gliadin IgA- and IgG-class antibodies constitutes a valid test in selecting patients suspected of having celiac disease. In turn the EmA-IgA antibodies constitute a confirmative test for indication of an intestinal biopsy. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/2193137/Serological_markers_and_celiac_disease:_a_new_diagnostic_approach L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2193137.ui DB - PRIME DP - Unbound Medicine ER -