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The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial.
Menopause. 2012 Feb; 19(2):202-10.M

Abstract

OBJECTIVE

The aim of this study was to investigate the effects of the natural S-equol supplement on skin aging in equol-nonproducing Japanese postmenopausal women.

METHODS

A randomized, double-blind, placebo-controlled trial examined the use of the natural S-equol supplement for 12 weeks in 101 postmenopausal Japanese women who were equol nonproducers. They were randomly assigned to one of three groups: placebo (n = 34), 10 mg S-equol/day (EQL10; n = 34), or 30 mg S-equol/day (EQL30; n = 33). Skin parameters of crow's-feet wrinkles (area and depth), hydration, transepidermal water loss, and elasticity were measured at baseline and at monthly intervals during treatment. Vaginal cytology, endometrial thickness, and mammography were performed before and after treatment. Serum hormone concentrations were measured at the same time as skin parameters.

RESULTS

The EQL10 and EQL30 groups showed significant reductions in wrinkle area compared with the placebo group (P < 0.05). There was a significant difference in wrinkle depth between the placebo group and the EQL30 group (P < 0.05). Other skin parameters did not show significant differences after the treatment in any group. There were no abnormal results in hormone status or gynecological examinations.

CONCLUSIONS

Our data suggest that natural S-equol supplementation (EQL10 and EQL30) may have a beneficial effect on crow's-feet wrinkles in postmenopausal women without serious adverse events.

Authors+Show Affiliations

Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, Saga, Japan. a_oyama@research.otsuka.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21934634

Citation

Oyama, Ayuko, et al. "The Effects of Natural S-equol Supplementation On Skin Aging in Postmenopausal Women: a Pilot Randomized Placebo-controlled Trial." Menopause (New York, N.Y.), vol. 19, no. 2, 2012, pp. 202-10.
Oyama A, Ueno T, Uchiyama S, et al. The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. Menopause. 2012;19(2):202-10.
Oyama, A., Ueno, T., Uchiyama, S., Aihara, T., Miyake, A., Kondo, S., & Matsunaga, K. (2012). The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. Menopause (New York, N.Y.), 19(2), 202-10. https://doi.org/10.1097/gme.0b013e318227427b
Oyama A, et al. The Effects of Natural S-equol Supplementation On Skin Aging in Postmenopausal Women: a Pilot Randomized Placebo-controlled Trial. Menopause. 2012;19(2):202-10. PubMed PMID: 21934634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of natural S-equol supplementation on skin aging in postmenopausal women: a pilot randomized placebo-controlled trial. AU - Oyama,Ayuko, AU - Ueno,Tomomi, AU - Uchiyama,Shigeto, AU - Aihara,Tomohiko, AU - Miyake,Akira, AU - Kondo,Sumio, AU - Matsunaga,Kayoko, PY - 2011/9/22/entrez PY - 2011/9/22/pubmed PY - 2012/5/15/medline SP - 202 EP - 10 JF - Menopause (New York, N.Y.) JO - Menopause VL - 19 IS - 2 N2 - OBJECTIVE: The aim of this study was to investigate the effects of the natural S-equol supplement on skin aging in equol-nonproducing Japanese postmenopausal women. METHODS: A randomized, double-blind, placebo-controlled trial examined the use of the natural S-equol supplement for 12 weeks in 101 postmenopausal Japanese women who were equol nonproducers. They were randomly assigned to one of three groups: placebo (n = 34), 10 mg S-equol/day (EQL10; n = 34), or 30 mg S-equol/day (EQL30; n = 33). Skin parameters of crow's-feet wrinkles (area and depth), hydration, transepidermal water loss, and elasticity were measured at baseline and at monthly intervals during treatment. Vaginal cytology, endometrial thickness, and mammography were performed before and after treatment. Serum hormone concentrations were measured at the same time as skin parameters. RESULTS: The EQL10 and EQL30 groups showed significant reductions in wrinkle area compared with the placebo group (P < 0.05). There was a significant difference in wrinkle depth between the placebo group and the EQL30 group (P < 0.05). Other skin parameters did not show significant differences after the treatment in any group. There were no abnormal results in hormone status or gynecological examinations. CONCLUSIONS: Our data suggest that natural S-equol supplementation (EQL10 and EQL30) may have a beneficial effect on crow's-feet wrinkles in postmenopausal women without serious adverse events. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/21934634/The_effects_of_natural_S_equol_supplementation_on_skin_aging_in_postmenopausal_women:_a_pilot_randomized_placebo_controlled_trial_ L2 - https://doi.org/10.1097/gme.0b013e318227427b DB - PRIME DP - Unbound Medicine ER -