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Accuracy of prenatal three-dimensional ultrasound in the diagnosis of cleft hard palate when cleft lip is present.
Ultrasound Obstet Gynecol. 2011 Oct; 38(4):440-4.UO

Abstract

OBJECTIVE

To investigate the accuracy of prenatal axial three-dimensional (3D) ultrasound in predicting the absence or presence of cleft palate in the presence of cleft lip.

METHODS

Between March 2005 and January 2009, there were 81 cases with a prenatal two-dimensional (2D) ultrasound screening diagnosis of unilateral or bilateral cleft lip at 22-25 weeks of gestation referred to our tertiary care center. Of these, 79 fetuses were included in this prospective study and two were excluded. Axial 3D ultrasound imaging of the fetal palate was performed and the diagnoses were compared with clinical findings at delivery. The frequencies of intact and cleft palate, the degree of association between the prenatal predictions and postnatal findings and the probability of detection of cleft lip and palate were determined.

RESULTS

Of 79 prenatal predictions, 77 (97%) were correct and the association between the prenatal predictions and postnatal findings was strong. The sensitivity for detection of cleft lip and palate within this high-risk population was 100% and the specificity was 90%. In one of the excluded cases, the palate could not be visualized due to a fetal prone position. There were chromosomal anomalies in 4% of cases and associated structural or growth anomalies in 23%, termination of pregnancy was carried out in 4% and intrauterine fetal demise occurred in 3%.

CONCLUSION

Axial 3D ultrasound of the fetal palate has high accuracy in identifying prenatal cleft palate when cleft lip is diagnosed at mid-trimester 2D ultrasound screening.

Authors+Show Affiliations

CHU Montpellier, Service de Gynécologie-Obstétrique, Hôpital Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, Montpellier, France. baeumler@free.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21936003

Citation

Bäumler, M, et al. "Accuracy of Prenatal Three-dimensional Ultrasound in the Diagnosis of Cleft Hard Palate when Cleft Lip Is Present." Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 38, no. 4, 2011, pp. 440-4.
Bäumler M, Faure JM, Bigorre M, et al. Accuracy of prenatal three-dimensional ultrasound in the diagnosis of cleft hard palate when cleft lip is present. Ultrasound Obstet Gynecol. 2011;38(4):440-4.
Bäumler, M., Faure, J. M., Bigorre, M., Bäumler-Patris, C., Boulot, P., Demattei, C., & Captier, G. (2011). Accuracy of prenatal three-dimensional ultrasound in the diagnosis of cleft hard palate when cleft lip is present. Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 38(4), 440-4. https://doi.org/10.1002/uog.8933
Bäumler M, et al. Accuracy of Prenatal Three-dimensional Ultrasound in the Diagnosis of Cleft Hard Palate when Cleft Lip Is Present. Ultrasound Obstet Gynecol. 2011;38(4):440-4. PubMed PMID: 21936003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accuracy of prenatal three-dimensional ultrasound in the diagnosis of cleft hard palate when cleft lip is present. AU - Bäumler,M, AU - Faure,J-M, AU - Bigorre,M, AU - Bäumler-Patris,C, AU - Boulot,P, AU - Demattei,C, AU - Captier,G, Y1 - 2011/08/25/ PY - 2010/12/23/accepted PY - 2011/9/22/entrez PY - 2011/9/22/pubmed PY - 2011/12/22/medline SP - 440 EP - 4 JF - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JO - Ultrasound Obstet Gynecol VL - 38 IS - 4 N2 - OBJECTIVE: To investigate the accuracy of prenatal axial three-dimensional (3D) ultrasound in predicting the absence or presence of cleft palate in the presence of cleft lip. METHODS: Between March 2005 and January 2009, there were 81 cases with a prenatal two-dimensional (2D) ultrasound screening diagnosis of unilateral or bilateral cleft lip at 22-25 weeks of gestation referred to our tertiary care center. Of these, 79 fetuses were included in this prospective study and two were excluded. Axial 3D ultrasound imaging of the fetal palate was performed and the diagnoses were compared with clinical findings at delivery. The frequencies of intact and cleft palate, the degree of association between the prenatal predictions and postnatal findings and the probability of detection of cleft lip and palate were determined. RESULTS: Of 79 prenatal predictions, 77 (97%) were correct and the association between the prenatal predictions and postnatal findings was strong. The sensitivity for detection of cleft lip and palate within this high-risk population was 100% and the specificity was 90%. In one of the excluded cases, the palate could not be visualized due to a fetal prone position. There were chromosomal anomalies in 4% of cases and associated structural or growth anomalies in 23%, termination of pregnancy was carried out in 4% and intrauterine fetal demise occurred in 3%. CONCLUSION: Axial 3D ultrasound of the fetal palate has high accuracy in identifying prenatal cleft palate when cleft lip is diagnosed at mid-trimester 2D ultrasound screening. SN - 1469-0705 UR - https://www.unboundmedicine.com/medline/citation/21936003/Accuracy_of_prenatal_three_dimensional_ultrasound_in_the_diagnosis_of_cleft_hard_palate_when_cleft_lip_is_present_ L2 - https://doi.org/10.1002/uog.8933 DB - PRIME DP - Unbound Medicine ER -