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A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice.
J Agric Food Chem 2011; 59(20):11287-93JA

Abstract

The immunomodulatory effects of a hot water extract from matured fruit of the date palm tree (Phoenix dactylifera L.) were investigated in comparison to those of prune and fig fruit in mice. The number of spleen IFN-γ(+)CD4(+), IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells was highest in mice given the date extract-added diet. Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-γ mRNA expression significantly in mouse Peyer's patch cell cultures. Chlorogenic acid and caffeic acid also increased the number of IFN-γ(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. On the other hand, a 70% ethanol-insoluble date extract treated with trypsin increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. These results indicate that some polyphenols and polysaccharides present in date fruit stimulate the cellular immune system in mice.

Authors+Show Affiliations

Interdisciplinary Graduate School of Science and Technology, Shinshu University, Minamiminowa-mura 8304, Kamiina-gun, Nagano 399-4598, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21936496

Citation

Karasawa, Koji, et al. "A Matured Fruit Extract of Date Palm Tree (Phoenix Dactylifera L.) Stimulates the Cellular Immune System in Mice." Journal of Agricultural and Food Chemistry, vol. 59, no. 20, 2011, pp. 11287-93.
Karasawa K, Uzuhashi Y, Hirota M, et al. A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice. J Agric Food Chem. 2011;59(20):11287-93.
Karasawa, K., Uzuhashi, Y., Hirota, M., & Otani, H. (2011). A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice. Journal of Agricultural and Food Chemistry, 59(20), pp. 11287-93. doi:10.1021/jf2029225.
Karasawa K, et al. A Matured Fruit Extract of Date Palm Tree (Phoenix Dactylifera L.) Stimulates the Cellular Immune System in Mice. J Agric Food Chem. 2011 Oct 26;59(20):11287-93. PubMed PMID: 21936496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice. AU - Karasawa,Koji, AU - Uzuhashi,Yuji, AU - Hirota,Mitsuru, AU - Otani,Hajime, Y1 - 2011/10/03/ PY - 2011/9/23/entrez PY - 2011/9/23/pubmed PY - 2012/3/6/medline SP - 11287 EP - 93 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 59 IS - 20 N2 - The immunomodulatory effects of a hot water extract from matured fruit of the date palm tree (Phoenix dactylifera L.) were investigated in comparison to those of prune and fig fruit in mice. The number of spleen IFN-γ(+)CD4(+), IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells was highest in mice given the date extract-added diet. Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-γ mRNA expression significantly in mouse Peyer's patch cell cultures. Chlorogenic acid and caffeic acid also increased the number of IFN-γ(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. On the other hand, a 70% ethanol-insoluble date extract treated with trypsin increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. These results indicate that some polyphenols and polysaccharides present in date fruit stimulate the cellular immune system in mice. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/21936496/A_matured_fruit_extract_of_date_palm_tree__Phoenix_dactylifera_L___stimulates_the_cellular_immune_system_in_mice_ L2 - https://dx.doi.org/10.1021/jf2029225 DB - PRIME DP - Unbound Medicine ER -