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A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice.

Abstract

The immunomodulatory effects of a hot water extract from matured fruit of the date palm tree (Phoenix dactylifera L.) were investigated in comparison to those of prune and fig fruit in mice. The number of spleen IFN-γ(+)CD4(+), IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells was highest in mice given the date extract-added diet. Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-γ mRNA expression significantly in mouse Peyer's patch cell cultures. Chlorogenic acid and caffeic acid also increased the number of IFN-γ(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. On the other hand, a 70% ethanol-insoluble date extract treated with trypsin increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. These results indicate that some polyphenols and polysaccharides present in date fruit stimulate the cellular immune system in mice.

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  • Authors+Show Affiliations

    ,

    Interdisciplinary Graduate School of Science and Technology, Shinshu University, Minamiminowa-mura 8304, Kamiina-gun, Nagano 399-4598, Japan.

    , ,

    Source

    Journal of agricultural and food chemistry 59:20 2011 Oct 26 pg 11287-93

    MeSH

    Animals
    Arecaceae
    Cells, Cultured
    Fruit
    Gene Expression
    Immunity, Cellular
    Interferon-gamma
    Male
    Mice
    Mice, Inbred C3H
    Peyer's Patches
    Plant Extracts
    Polyphenols
    Spleen

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21936496

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice. AU - Karasawa,Koji, AU - Uzuhashi,Yuji, AU - Hirota,Mitsuru, AU - Otani,Hajime, Y1 - 2011/10/03/ PY - 2011/9/23/entrez PY - 2011/9/23/pubmed PY - 2012/3/6/medline SP - 11287 EP - 93 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 59 IS - 20 N2 - The immunomodulatory effects of a hot water extract from matured fruit of the date palm tree (Phoenix dactylifera L.) were investigated in comparison to those of prune and fig fruit in mice. The number of spleen IFN-γ(+)CD4(+), IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells was highest in mice given the date extract-added diet. Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-γ mRNA expression significantly in mouse Peyer's patch cell cultures. Chlorogenic acid and caffeic acid also increased the number of IFN-γ(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. On the other hand, a 70% ethanol-insoluble date extract treated with trypsin increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. These results indicate that some polyphenols and polysaccharides present in date fruit stimulate the cellular immune system in mice. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/21936496/A_matured_fruit_extract_of_date_palm_tree__Phoenix_dactylifera_L___stimulates_the_cellular_immune_system_in_mice_ L2 - https://dx.doi.org/10.1021/jf2029225 DB - PRIME DP - Unbound Medicine ER -