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Reduced risk of breast cancer recurrence in patients using ACE inhibitors, ARBs, and/or statins.
Cancer Invest. 2011 Nov; 29(9):585-93.CI

Abstract

BACKGROUND

Epidemiologic and biochemical evidence suggest a role of statins and angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) as anti-neoplastic agents. This study was designed to evaluate the association between the use of these agents and the risk of breast cancer recurrence.

METHODS

We reviewed the medical records of patients treated for stage II/III breast cancer between 1999 and 2005. Statin and ACE-inhibitors/ARB users were defined as patients who took these medications for at least 6 months in no evidence of disease (NED) stage after the initial diagnosis. The primary outcome was disease-free survival and the secondary was overall survival. The Kaplan-Meier and Cox proportional hazard models were used.

RESULTS

A total of 703 patients were included. The median and maximal of follow up was 55 and 118 months, respectively. A total of 168 patients used ACE-inhibitors/ARBs, 156 patients used statins, and 81 used both. Univariate analysis showed significant reduction in breast cancer recurrence among patients who used ACE-inhibitors/ARBs (hazard ratio (HR) = 0.57; 95% CI: 0.37-0.89; p = .013) or statins (HR = 0.43; 95% CI: 0.26-0.70; p < .001). After adjusting for multiple variables, the use of ACE-inhibitors/ARBs (HR = 0.49; 95% CI: 0.31-0.76; p = .002) and statins (HR = 0.40; 95% CI: 0.24-0.67; p < .001) remained significant and an additive effect was found on those who used both drugs (HR = 0.30 95% CI: 0.15-0.61; p = .001). No association was found regarding overall survival.

CONCLUSIONS

The use of ACE-inhibitors/ARBs, statins, and the combination of both were all associated with a reduced risk of breast cancer recurrence. This observation should prompt further exploration.

Authors+Show Affiliations

Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ykchae@mdanderson.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21936625

Citation

Chae, Young Kwang, et al. "Reduced Risk of Breast Cancer Recurrence in Patients Using ACE Inhibitors, ARBs, And/or Statins." Cancer Investigation, vol. 29, no. 9, 2011, pp. 585-93.
Chae YK, Valsecchi ME, Kim J, et al. Reduced risk of breast cancer recurrence in patients using ACE inhibitors, ARBs, and/or statins. Cancer Invest. 2011;29(9):585-93.
Chae, Y. K., Valsecchi, M. E., Kim, J., Bianchi, A. L., Khemasuwan, D., Desai, A., & Tester, W. (2011). Reduced risk of breast cancer recurrence in patients using ACE inhibitors, ARBs, and/or statins. Cancer Investigation, 29(9), 585-93. https://doi.org/10.3109/07357907.2011.616252
Chae YK, et al. Reduced Risk of Breast Cancer Recurrence in Patients Using ACE Inhibitors, ARBs, And/or Statins. Cancer Invest. 2011;29(9):585-93. PubMed PMID: 21936625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced risk of breast cancer recurrence in patients using ACE inhibitors, ARBs, and/or statins. AU - Chae,Young Kwang, AU - Valsecchi,Matias E, AU - Kim,Jongoh, AU - Bianchi,Anabella Lucca, AU - Khemasuwan,Danai, AU - Desai,Ajit, AU - Tester,William, Y1 - 2011/09/21/ PY - 2011/9/23/entrez PY - 2011/9/23/pubmed PY - 2012/1/31/medline SP - 585 EP - 93 JF - Cancer investigation JO - Cancer Invest. VL - 29 IS - 9 N2 - BACKGROUND: Epidemiologic and biochemical evidence suggest a role of statins and angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs) as anti-neoplastic agents. This study was designed to evaluate the association between the use of these agents and the risk of breast cancer recurrence. METHODS: We reviewed the medical records of patients treated for stage II/III breast cancer between 1999 and 2005. Statin and ACE-inhibitors/ARB users were defined as patients who took these medications for at least 6 months in no evidence of disease (NED) stage after the initial diagnosis. The primary outcome was disease-free survival and the secondary was overall survival. The Kaplan-Meier and Cox proportional hazard models were used. RESULTS: A total of 703 patients were included. The median and maximal of follow up was 55 and 118 months, respectively. A total of 168 patients used ACE-inhibitors/ARBs, 156 patients used statins, and 81 used both. Univariate analysis showed significant reduction in breast cancer recurrence among patients who used ACE-inhibitors/ARBs (hazard ratio (HR) = 0.57; 95% CI: 0.37-0.89; p = .013) or statins (HR = 0.43; 95% CI: 0.26-0.70; p < .001). After adjusting for multiple variables, the use of ACE-inhibitors/ARBs (HR = 0.49; 95% CI: 0.31-0.76; p = .002) and statins (HR = 0.40; 95% CI: 0.24-0.67; p < .001) remained significant and an additive effect was found on those who used both drugs (HR = 0.30 95% CI: 0.15-0.61; p = .001). No association was found regarding overall survival. CONCLUSIONS: The use of ACE-inhibitors/ARBs, statins, and the combination of both were all associated with a reduced risk of breast cancer recurrence. This observation should prompt further exploration. SN - 1532-4192 UR - https://www.unboundmedicine.com/medline/citation/21936625/Reduced_risk_of_breast_cancer_recurrence_in_patients_using_ACE_inhibitors_ARBs_and/or_statins_ L2 - http://www.tandfonline.com/doi/full/10.3109/07357907.2011.616252 DB - PRIME DP - Unbound Medicine ER -