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Differential responses to selenomethionine supplementation by sex and genotype in healthy adults.
Br J Nutr 2012; 107(10):1514-25BJ

Abstract

A year-long intervention trial was conducted to characterise the responses of multiple biomarkers of Se status in healthy American adults to supplemental selenomethionine (SeMet) and to identify factors affecting those responses. A total of 261 men and women were randomised to four doses of Se (0, 50, 100 or 200 μg/d as L-SeMet) for 12 months. Responses of several biomarkers of Se status (plasma Se, serum selenoprotein P (SEPP1), plasma glutathione peroxidase activity (GPX3), buccal cell Se, urinary Se) were determined relative to genotype of four selenoproteins (GPX1, GPX3, SEPP1, selenoprotein 15), dietary Se intake and parameters of single-carbon metabolism. Results showed that supplemental SeMet did not affect GPX3 activity or SEPP1 concentration, but produced significant, dose-dependent increases in the Se contents of plasma, urine and buccal cells, each of which plateaued by 9-12 months and was linearly related to effective Se dose (μg/d per kg0·75). The increase in urinary Se excretion was greater for women than men, and for individuals of the GPX1 679 T/T genotype than for those of the GPX1 679 C/C genotype. It is concluded that the most responsive Se-biomarkers in this non-deficient cohort were those related to body Se pools: plasma, buccal cell and urinary Se concentrations. Changes in plasma Se resulted from increases in its non-specific component and were affected by both sex and GPX1 genotype. In a cohort of relatively high Se status, the Se intake (as SeMet) required to support plasma Se concentration at a target level (Se(pl-target)) is: Se(in) = [(Se(pl - target) - Se(pl))/(18.2ng d kg⁰.⁷⁵/ml per mu g)] .

Authors+Show Affiliations

Grand Forks Human Nutrition Research Center, USDA-ARS, 2420 2nd Avenue North, Stop 9034, Grand Forks, ND 58202-9034, USA. gerald.combs@ars.usda.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21936966

Citation

Combs, Gerald F., et al. "Differential Responses to Selenomethionine Supplementation By Sex and Genotype in Healthy Adults." The British Journal of Nutrition, vol. 107, no. 10, 2012, pp. 1514-25.
Combs GF, Jackson MI, Watts JC, et al. Differential responses to selenomethionine supplementation by sex and genotype in healthy adults. Br J Nutr. 2012;107(10):1514-25.
Combs, G. F., Jackson, M. I., Watts, J. C., Johnson, L. K., Zeng, H., Idso, J., ... Milner, J. A. (2012). Differential responses to selenomethionine supplementation by sex and genotype in healthy adults. The British Journal of Nutrition, 107(10), pp. 1514-25. doi:10.1017/S0007114511004715.
Combs GF, et al. Differential Responses to Selenomethionine Supplementation By Sex and Genotype in Healthy Adults. Br J Nutr. 2012;107(10):1514-25. PubMed PMID: 21936966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential responses to selenomethionine supplementation by sex and genotype in healthy adults. AU - Combs,Gerald F,Jr AU - Jackson,Matthew I, AU - Watts,Jennifer C, AU - Johnson,LuAnn K, AU - Zeng,Huawei, AU - Idso,Joseph, AU - Schomburg,Lutz, AU - Hoeg,Antonia, AU - Hoefig,Carolin S, AU - Chiang,Emily C, AU - Waters,David J, AU - Davis,Cindy D, AU - Milner,John A, Y1 - 2011/09/22/ PY - 2011/9/23/entrez PY - 2011/9/23/pubmed PY - 2012/7/11/medline SP - 1514 EP - 25 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 107 IS - 10 N2 - A year-long intervention trial was conducted to characterise the responses of multiple biomarkers of Se status in healthy American adults to supplemental selenomethionine (SeMet) and to identify factors affecting those responses. A total of 261 men and women were randomised to four doses of Se (0, 50, 100 or 200 μg/d as L-SeMet) for 12 months. Responses of several biomarkers of Se status (plasma Se, serum selenoprotein P (SEPP1), plasma glutathione peroxidase activity (GPX3), buccal cell Se, urinary Se) were determined relative to genotype of four selenoproteins (GPX1, GPX3, SEPP1, selenoprotein 15), dietary Se intake and parameters of single-carbon metabolism. Results showed that supplemental SeMet did not affect GPX3 activity or SEPP1 concentration, but produced significant, dose-dependent increases in the Se contents of plasma, urine and buccal cells, each of which plateaued by 9-12 months and was linearly related to effective Se dose (μg/d per kg0·75). The increase in urinary Se excretion was greater for women than men, and for individuals of the GPX1 679 T/T genotype than for those of the GPX1 679 C/C genotype. It is concluded that the most responsive Se-biomarkers in this non-deficient cohort were those related to body Se pools: plasma, buccal cell and urinary Se concentrations. Changes in plasma Se resulted from increases in its non-specific component and were affected by both sex and GPX1 genotype. In a cohort of relatively high Se status, the Se intake (as SeMet) required to support plasma Se concentration at a target level (Se(pl-target)) is: Se(in) = [(Se(pl - target) - Se(pl))/(18.2ng d kg⁰.⁷⁵/ml per mu g)] . SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21936966/Differential_responses_to_selenomethionine_supplementation_by_sex_and_genotype_in_healthy_adults_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511004715/type/journal_article DB - PRIME DP - Unbound Medicine ER -