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Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off.
Am J Ophthalmol. 2012 Jan; 153(1):128-36.AJ

Abstract

PURPOSE

To evaluate the correlation between morphologic changes in the outer retina and visual function after successful repair of rhegmatogenous retinal detachment with macula off.

DESIGN

Observational case series.

SETTINGS

Dijon University Hospital.

PATIENTS

Thirty patients (30 eyes) with successful repair of rhegmatogenous retinal detachment after macula off and a minimum 6-month follow-up after surgery.

MAIN OUTCOME MEASURES

Spectral-domain optical coherence tomography (SD-OCT) of the outer retina, fundus autofluorescence (FAF), and microperimetry.

RESULTS

Twenty of 30 eyes presented microstructural changes within the photoreceptor layer (66.7%). Of these, half of the patients (50%) had more than 1 lesion. Disrupted inner segment/outer segment (IS/OS) junction was noted in 16 out of 30 eyes (53.3%), irregular hyporeflectivity in the photoreceptor outer segments (PROS) was observed in 17 eyes (56.7%), external limiting membrane was discontinued in 10 eyes (33.3%), and hyperreflective spots in the outer nuclear layer were observed in 5 eyes (16.7%). FAF changes were detected in only 5 eyes (16.7%). Abnormalities in the IS/OS junction were significantly associated with lower foveal and macular sensitivity, thinner PROS, and global photoreceptor changes (P = .014, P = .003, P = .006, P < .0001, respectively). Patients with a normal foveal profile showed similar findings.

CONCLUSIONS

SD-OCT and microperimetry seem to be appropriate tools to determine the visual and the anatomic recovery of the macula after surgery.

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Authors+Show Affiliations

Delolme MP
Department of Ophthalmology, University Hospital, Dijon, France.
Dugas B
No affiliation info available
Nicot F
No affiliation info available
Muselier A
No affiliation info available
Bron AM
No affiliation info available
Creuzot-Garcher C
No affiliation info available

MeSH

AgedAged, 80 and overEndotamponadeFemaleFluorescein AngiographyFollow-Up StudiesHumansMaleMiddle AgedPhotoreceptor Cells, VertebrateRetinal DetachmentRetrospective StudiesScleral BucklingTomography, Optical CoherenceVisual AcuityVisual Field TestsVitrectomy

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21937016

Citation

Delolme, Marie Pierre, et al. "Anatomical and Functional Macular Changes After Rhegmatogenous Retinal Detachment With Macula Off." American Journal of Ophthalmology, vol. 153, no. 1, 2012, pp. 128-36.
Delolme MP, Dugas B, Nicot F, et al. Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off. Am J Ophthalmol. 2012;153(1):128-36.
Delolme, M. P., Dugas, B., Nicot, F., Muselier, A., Bron, A. M., & Creuzot-Garcher, C. (2012). Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off. American Journal of Ophthalmology, 153(1), 128-36. https://doi.org/10.1016/j.ajo.2011.06.010
Delolme MP, et al. Anatomical and Functional Macular Changes After Rhegmatogenous Retinal Detachment With Macula Off. Am J Ophthalmol. 2012;153(1):128-36. PubMed PMID: 21937016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off. AU - Delolme,Marie Pierre, AU - Dugas,Brice, AU - Nicot,Frédéric, AU - Muselier,Aurore, AU - Bron,Alain M, AU - Creuzot-Garcher,Catherine, Y1 - 2011/09/19/ PY - 2011/01/17/received PY - 2011/05/26/revised PY - 2011/06/04/accepted PY - 2011/9/23/entrez PY - 2011/9/23/pubmed PY - 2012/2/2/medline SP - 128 EP - 36 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 153 IS - 1 N2 - PURPOSE: To evaluate the correlation between morphologic changes in the outer retina and visual function after successful repair of rhegmatogenous retinal detachment with macula off. DESIGN: Observational case series. SETTINGS: Dijon University Hospital. PATIENTS: Thirty patients (30 eyes) with successful repair of rhegmatogenous retinal detachment after macula off and a minimum 6-month follow-up after surgery. MAIN OUTCOME MEASURES: Spectral-domain optical coherence tomography (SD-OCT) of the outer retina, fundus autofluorescence (FAF), and microperimetry. RESULTS: Twenty of 30 eyes presented microstructural changes within the photoreceptor layer (66.7%). Of these, half of the patients (50%) had more than 1 lesion. Disrupted inner segment/outer segment (IS/OS) junction was noted in 16 out of 30 eyes (53.3%), irregular hyporeflectivity in the photoreceptor outer segments (PROS) was observed in 17 eyes (56.7%), external limiting membrane was discontinued in 10 eyes (33.3%), and hyperreflective spots in the outer nuclear layer were observed in 5 eyes (16.7%). FAF changes were detected in only 5 eyes (16.7%). Abnormalities in the IS/OS junction were significantly associated with lower foveal and macular sensitivity, thinner PROS, and global photoreceptor changes (P = .014, P = .003, P = .006, P < .0001, respectively). Patients with a normal foveal profile showed similar findings. CONCLUSIONS: SD-OCT and microperimetry seem to be appropriate tools to determine the visual and the anatomic recovery of the macula after surgery. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/21937016/Anatomical_and_functional_macular_changes_after_rhegmatogenous_retinal_detachment_with_macula_off_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(11)00481-8 DB - PRIME DP - Unbound Medicine ER -