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The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study.
Am J Geriatr Psychiatry. 2012 Jul; 20(7):635-9.AJ

Abstract

OBJECTIVE

To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline.

DESIGN

Longitudinal.

PARTICIPANTS

We assessed 1528 individuals, aged 60-64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants.

RESULTS

Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment.

CONCLUSIONS

In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline.

Authors+Show Affiliations

Centre for Mental Health Research, Australian National University, Canberra, Australia. nicolas.cherbuin@anu.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21937919

Citation

Cherbuin, Nicolas, and Kaarin J. Anstey. "The Mediterranean Diet Is Not Related to Cognitive Change in a Large Prospective Investigation: the PATH Through Life Study." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 20, no. 7, 2012, pp. 635-9.
Cherbuin N, Anstey KJ. The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study. Am J Geriatr Psychiatry. 2012;20(7):635-9.
Cherbuin, N., & Anstey, K. J. (2012). The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 20(7), 635-9. https://doi.org/10.1097/JGP.0b013e31823032a9
Cherbuin N, Anstey KJ. The Mediterranean Diet Is Not Related to Cognitive Change in a Large Prospective Investigation: the PATH Through Life Study. Am J Geriatr Psychiatry. 2012;20(7):635-9. PubMed PMID: 21937919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study. AU - Cherbuin,Nicolas, AU - Anstey,Kaarin J, PY - 2011/9/23/entrez PY - 2011/9/23/pubmed PY - 2012/11/14/medline SP - 635 EP - 9 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 20 IS - 7 N2 - OBJECTIVE: To determine whether the Mediterranean diet and other dietary variables are predictors of transition from healthy cognitive aging to mild cognitive impairment and cognitive decline. DESIGN: Longitudinal. PARTICIPANTS: We assessed 1528 individuals, aged 60-64 years, who were participating in a prospective epidemiological study of mental health and aging. We tested participants at two time points, 4 years apart, for mild cognitive impairment using either the International Consensus Criteria, impairment on the Clinical Dementia Rating scale (Clinical Dementia Rating: 0.5), or any of a suite of criteria sets (any mild cognitive disorder). We used logistic regression to assess the dietary predictors of conversion to clinical diagnoses and multiple regression to identify the predictors of cognitive decline (change in global cognition) in healthy participants. RESULTS: Of the 1528 participants with no cognitive impairment in the first wave of assessment and complete data, 10 participants were diagnosed with mild cognitive impairment, 19 with Clinical Dementia Rating 0.5, and 37 participants presented with any mild cognitive disorder at follow-up. Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment. CONCLUSIONS: In this large longitudinal investigation of generally healthy individuals Mediterranean diet was not found to be protective of cognitive decline. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/21937919/The_Mediterranean_diet_is_not_related_to_cognitive_change_in_a_large_prospective_investigation:_the_PATH_Through_Life_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064-7481(12)62090-9 DB - PRIME DP - Unbound Medicine ER -