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A communicational link between skeletal muscle, brain, and cells of the immune system.
Int J Sports Med 1990; 11 Suppl 2:S122-8IJ

Abstract

The present paper reviews evidence for the role of specific amino acids in the etiology of fatigue and the overtraining syndrome in athletes. An increase in the plasma concentration ratio of free tryptophan: branched-chain amino acids may mediate an increase in 5-HT synthesis in the brain and thus induce fatigue during exercise. Glutamine is essential for the proper functioning of cells of the immune system and a decrease in plasma glutamine concentration post-exercise and in overtraining may induce an impairment in immune function. Branched-chain amino acids may play a central role in both these processes. Thus, they compete with free tryptophan for entry into the brain. Branched-chain amino acids may also be important precursors of nitrogen for the synthesis of glutamine in skeletal muscle or important in the control of glutamine release from muscle. Consequently, the metabolism of glutamine, tryptophan, and branched-chain amino acids may be the key to understanding some aspects of central fatigue and some aspects of immunosuppression that are very relevant to athletic endeavor. They may be also relevant to other physiological and pathological conditions.

Authors+Show Affiliations

Department of Biochemistry, University of Oxford.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2193890

Citation

Parry-Billings, M, et al. "A Communicational Link Between Skeletal Muscle, Brain, and Cells of the Immune System." International Journal of Sports Medicine, vol. 11 Suppl 2, 1990, pp. S122-8.
Parry-Billings M, Blomstrand E, McAndrew N, et al. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med. 1990;11 Suppl 2:S122-8.
Parry-Billings, M., Blomstrand, E., McAndrew, N., & Newsholme, E. A. (1990). A communicational link between skeletal muscle, brain, and cells of the immune system. International Journal of Sports Medicine, 11 Suppl 2, pp. S122-8.
Parry-Billings M, et al. A Communicational Link Between Skeletal Muscle, Brain, and Cells of the Immune System. Int J Sports Med. 1990;11 Suppl 2:S122-8. PubMed PMID: 2193890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A communicational link between skeletal muscle, brain, and cells of the immune system. AU - Parry-Billings,M, AU - Blomstrand,E, AU - McAndrew,N, AU - Newsholme,E A, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - S122 EP - 8 JF - International journal of sports medicine JO - Int J Sports Med VL - 11 Suppl 2 N2 - The present paper reviews evidence for the role of specific amino acids in the etiology of fatigue and the overtraining syndrome in athletes. An increase in the plasma concentration ratio of free tryptophan: branched-chain amino acids may mediate an increase in 5-HT synthesis in the brain and thus induce fatigue during exercise. Glutamine is essential for the proper functioning of cells of the immune system and a decrease in plasma glutamine concentration post-exercise and in overtraining may induce an impairment in immune function. Branched-chain amino acids may play a central role in both these processes. Thus, they compete with free tryptophan for entry into the brain. Branched-chain amino acids may also be important precursors of nitrogen for the synthesis of glutamine in skeletal muscle or important in the control of glutamine release from muscle. Consequently, the metabolism of glutamine, tryptophan, and branched-chain amino acids may be the key to understanding some aspects of central fatigue and some aspects of immunosuppression that are very relevant to athletic endeavor. They may be also relevant to other physiological and pathological conditions. SN - 0172-4622 UR - https://www.unboundmedicine.com/medline/citation/2193890/A_communicational_link_between_skeletal_muscle_brain_and_cells_of_the_immune_system_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1024863 DB - PRIME DP - Unbound Medicine ER -