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Effect of metformin therapy on vitamin D and vitamin B₁₂ levels in patients with type 2 diabetes mellitus.
Endocr Pract 2012 Mar-Apr; 18(2):179-84EP

Abstract

OBJECTIVE

To determine the effect of metformin on 25-hydroxyvitamin D [25(OH)D] and vitamin B₁₂ levels in patients with type 2 diabetes mellitus.

METHODS

We performed a retrospective review of medical records of patients treated between 2003 and 2009 at Loyola University Medical Center, Maywood, Illinois, in both ambulatory primary care and endocrinology clinics. The study cohort consisted of 706 patients with type 2 diabetes mellitus who were 20 to 93 years old (mean age, 63 ± 13) and had a mean body mass index of 33.1 kg/m². Of these patients, 42% were treated with metformin, and 34% had been diagnosed with osteoporosis or osteopenia.

RESULTS

Patients taking metformin had statistically significant lower vitamin B₁₂ levels than those not receiving metformin (P<.0001; 95% confidence interval [CI] = -220 to -84 pg/mL). No statistically significant difference was found between users and nonusers of metformin in regard to 25(OH)D levels when adjusted for variables (P = .297; 95% CI for mean difference = -0.7 to 2.2 ng/mL). Metformin use did not adversely affect successful treatment of vitamin D deficiency in this patient population as a whole, nor did it affect the subgroup with osteoporosis (P = .956). The patients with osteoporosis had statistically significant lower baseline 25(OH)D levels in comparison with those without osteoporosis, when adjustments were made for all variables (P = .003; 95% CI = 0.7 to 3.5 ng/mL).

CONCLUSION

This study confirms the higher prevalence of vitamin B₁₂ deficiency in metformin-treated patients with type 2 diabetes than in those not treated with metformin. This study also suggests that vitamin D deficiency is not a clinical concern among metformin-treated patients with type 2 diabetes and that metformin does not negatively affect treatment of vitamin D deficiency in these patients.

Authors+Show Affiliations

Department of General Internal Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA. ekos@lumc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21940283

Citation

Kos, Elizabeth, et al. "Effect of Metformin Therapy On Vitamin D and Vitamin B₁₂ Levels in Patients With Type 2 Diabetes Mellitus." Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, vol. 18, no. 2, 2012, pp. 179-84.
Kos E, Liszek MJ, Emanuele MA, et al. Effect of metformin therapy on vitamin D and vitamin B₁₂ levels in patients with type 2 diabetes mellitus. Endocr Pract. 2012;18(2):179-84.
Kos, E., Liszek, M. J., Emanuele, M. A., Durazo-Arvizu, R., & Camacho, P. (2012). Effect of metformin therapy on vitamin D and vitamin B₁₂ levels in patients with type 2 diabetes mellitus. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 18(2), pp. 179-84. doi:10.4158/EP11009.OR.
Kos E, et al. Effect of Metformin Therapy On Vitamin D and Vitamin B₁₂ Levels in Patients With Type 2 Diabetes Mellitus. Endocr Pract. 2012;18(2):179-84. PubMed PMID: 21940283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of metformin therapy on vitamin D and vitamin B₁₂ levels in patients with type 2 diabetes mellitus. AU - Kos,Elizabeth, AU - Liszek,Mary Jo, AU - Emanuele,Mary Ann, AU - Durazo-Arvizu,Ramon, AU - Camacho,Pauline, PY - 2011/9/24/entrez PY - 2011/9/24/pubmed PY - 2012/8/9/medline SP - 179 EP - 84 JF - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JO - Endocr Pract VL - 18 IS - 2 N2 - OBJECTIVE: To determine the effect of metformin on 25-hydroxyvitamin D [25(OH)D] and vitamin B₁₂ levels in patients with type 2 diabetes mellitus. METHODS: We performed a retrospective review of medical records of patients treated between 2003 and 2009 at Loyola University Medical Center, Maywood, Illinois, in both ambulatory primary care and endocrinology clinics. The study cohort consisted of 706 patients with type 2 diabetes mellitus who were 20 to 93 years old (mean age, 63 ± 13) and had a mean body mass index of 33.1 kg/m². Of these patients, 42% were treated with metformin, and 34% had been diagnosed with osteoporosis or osteopenia. RESULTS: Patients taking metformin had statistically significant lower vitamin B₁₂ levels than those not receiving metformin (P<.0001; 95% confidence interval [CI] = -220 to -84 pg/mL). No statistically significant difference was found between users and nonusers of metformin in regard to 25(OH)D levels when adjusted for variables (P = .297; 95% CI for mean difference = -0.7 to 2.2 ng/mL). Metformin use did not adversely affect successful treatment of vitamin D deficiency in this patient population as a whole, nor did it affect the subgroup with osteoporosis (P = .956). The patients with osteoporosis had statistically significant lower baseline 25(OH)D levels in comparison with those without osteoporosis, when adjustments were made for all variables (P = .003; 95% CI = 0.7 to 3.5 ng/mL). CONCLUSION: This study confirms the higher prevalence of vitamin B₁₂ deficiency in metformin-treated patients with type 2 diabetes than in those not treated with metformin. This study also suggests that vitamin D deficiency is not a clinical concern among metformin-treated patients with type 2 diabetes and that metformin does not negatively affect treatment of vitamin D deficiency in these patients. SN - 1934-2403 UR - https://www.unboundmedicine.com/medline/citation/21940283/Effect_of_metformin_therapy_on_vitamin_D_and_vitamin_B₁₂_levels_in_patients_with_type_2_diabetes_mellitus_ L2 - http://journals.aace.com/doi/10.4158/EP11009.OR?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -