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[Effect of acupuncture on serum leptin level in patients with type II diabetes mellitus].
Zhen Ci Yan Jiu. 2011 Aug; 36(4):288-91.ZC

Abstract

OBJECTIVE

To study the relationship between serum leptin and insulin resistance, and to analyze the effect of acupuncture on serum leptin level in patients with type-II diabetes mellitus (DM).

METHODS

A total of 80 type-II DM patients were randomized into acupuncture and medication groups. Acupuncture was applied to Yishu (EX), Feishu (BL13), Pishu (BL 20), etc. according to syndrome identification. The treatment was given once every other day for 12 weeks. For patients in the medication group, Glibenclamide (2.5-7.5 mg/time, 1-2 times/d according to blood sugar level) was given for 12 weeks. Fasting blood glucose (FBG), fasting insulin (FINS) and fasting leptin (FLP) were detected by using glucose oxidase method, radioimmunoassay and ELISA, respectively. Insulin sensitivity index (ISI) and homeostasis model assessment-insulin resistance (HOMA-IR) were calculated.

RESULTS

In comparison with pre-treatment, FBG levels and HOMA-IR in both acupuncture and medication groups, and FINS and FLP levels in the acupuncture group were decreased significantly (P < 0.01), while ISI in both acupuncture and medication groups, and FINS level in the medication group were increased remarkably after the treatment (P < 0.01). Comparison between two groups showed that after the treatment, FINS and FLP levels, and HOMA-IR of the acupuncture group were considerably lower than those of the medication group (P < 0.01), while ISI of the acupuncture group was significantly higher than that of the medication group (P < 0.01).

CONCLUSION

Acupuncture therapy is effective in lowering FLP level, which may contribute to its clinical effect in improving type-II DM.

Authors+Show Affiliations

Cai H
Department of Integrated Chinese and Western Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China. njzy_caihui@163.com
Zhao LJ
No affiliation info available
Zhao ZM
No affiliation info available
Guo JH
No affiliation info available
Yuan AH
No affiliation info available

MeSH

Acupuncture TherapyAdultAgedBlood GlucoseDiabetes Mellitus, Type 2FastingFemaleHumansInsulinInsulin ResistanceLeptinMaleMiddle Aged

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21942183

Citation

Cai, Hui, et al. "[Effect of Acupuncture On Serum Leptin Level in Patients With Type II Diabetes Mellitus]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 36, no. 4, 2011, pp. 288-91.
Cai H, Zhao LJ, Zhao ZM, et al. [Effect of acupuncture on serum leptin level in patients with type II diabetes mellitus]. Zhen Ci Yan Jiu. 2011;36(4):288-91.
Cai, H., Zhao, L. J., Zhao, Z. M., Guo, J. H., & Yuan, A. H. (2011). [Effect of acupuncture on serum leptin level in patients with type II diabetes mellitus]. Zhen Ci Yan Jiu = Acupuncture Research, 36(4), 288-91.
Cai H, et al. [Effect of Acupuncture On Serum Leptin Level in Patients With Type II Diabetes Mellitus]. Zhen Ci Yan Jiu. 2011;36(4):288-91. PubMed PMID: 21942183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of acupuncture on serum leptin level in patients with type II diabetes mellitus]. AU - Cai,Hui, AU - Zhao,Ling-jie, AU - Zhao,Zhi-ming, AU - Guo,Jun-hao, AU - Yuan,Ai-hong, PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2011/10/26/medline SP - 288 EP - 91 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 36 IS - 4 N2 - OBJECTIVE: To study the relationship between serum leptin and insulin resistance, and to analyze the effect of acupuncture on serum leptin level in patients with type-II diabetes mellitus (DM). METHODS: A total of 80 type-II DM patients were randomized into acupuncture and medication groups. Acupuncture was applied to Yishu (EX), Feishu (BL13), Pishu (BL 20), etc. according to syndrome identification. The treatment was given once every other day for 12 weeks. For patients in the medication group, Glibenclamide (2.5-7.5 mg/time, 1-2 times/d according to blood sugar level) was given for 12 weeks. Fasting blood glucose (FBG), fasting insulin (FINS) and fasting leptin (FLP) were detected by using glucose oxidase method, radioimmunoassay and ELISA, respectively. Insulin sensitivity index (ISI) and homeostasis model assessment-insulin resistance (HOMA-IR) were calculated. RESULTS: In comparison with pre-treatment, FBG levels and HOMA-IR in both acupuncture and medication groups, and FINS and FLP levels in the acupuncture group were decreased significantly (P < 0.01), while ISI in both acupuncture and medication groups, and FINS level in the medication group were increased remarkably after the treatment (P < 0.01). Comparison between two groups showed that after the treatment, FINS and FLP levels, and HOMA-IR of the acupuncture group were considerably lower than those of the medication group (P < 0.01), while ISI of the acupuncture group was significantly higher than that of the medication group (P < 0.01). CONCLUSION: Acupuncture therapy is effective in lowering FLP level, which may contribute to its clinical effect in improving type-II DM. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/21942183/[Effect_of_acupuncture_on_serum_leptin_level_in_patients_with_type_II_diabetes_mellitus]_ DB - PRIME DP - Unbound Medicine ER -