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Interaction of MTHFR 1298C with ACE D allele augments the risk of diabetic nephropathy in Western Iran.
DNA Cell Biol 2012; 31(4):553-9DC

Abstract

The aim of the current study was to examine the influence of interaction between polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C with angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism on the risk of diabetic nephropathy (DN). In a case control study using polymerase chain reaction (PCR)- and PCR-restriction fragment length polymorphism (RFLP), the presence of three polymorphisms in 140 patients with type 2 diabetes mellitus (T2DM) with nephropathy including patients with micro- and macro-albuminuria and 72 patients with normoalbuminuria from Western Iran were investigated. In the presence of both MTHFR 677 T and ACE D alleles, there was a trend toward increased risk of DN 2.68-fold (p=0.054). The possession of both MTHFR 677 T and ACE D alleles increased the risk of macro-albuminuria four times (p=0.035). The concomitant presence of both MTHFR 1298 C and ACE D alleles increased the risk of macro-albuminuria 7.8-fold (p=0.012). In addition, the risk of progression from micro- to macro-albuminuria in the presence of both alleles tended to be increased (4.1-fold, p=0.09). Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C677T or A1298C polymorphism on the increased risk of DN among patients with T2DM. We found that MTHFR 1298 C strongly interacts with the ACE D allele and augments the risk of DN in our population.

Authors+Show Affiliations

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. zrahimi@kums.ac.irNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21942443

Citation

Rahimi, Zohreh, et al. "Interaction of MTHFR 1298C With ACE D Allele Augments the Risk of Diabetic Nephropathy in Western Iran." DNA and Cell Biology, vol. 31, no. 4, 2012, pp. 553-9.
Rahimi Z, Hasanvand A, Felehgari V. Interaction of MTHFR 1298C with ACE D allele augments the risk of diabetic nephropathy in Western Iran. DNA Cell Biol. 2012;31(4):553-9.
Rahimi, Z., Hasanvand, A., & Felehgari, V. (2012). Interaction of MTHFR 1298C with ACE D allele augments the risk of diabetic nephropathy in Western Iran. DNA and Cell Biology, 31(4), pp. 553-9. doi:10.1089/dna.2011.1364.
Rahimi Z, Hasanvand A, Felehgari V. Interaction of MTHFR 1298C With ACE D Allele Augments the Risk of Diabetic Nephropathy in Western Iran. DNA Cell Biol. 2012;31(4):553-9. PubMed PMID: 21942443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of MTHFR 1298C with ACE D allele augments the risk of diabetic nephropathy in Western Iran. AU - Rahimi,Zohreh, AU - Hasanvand,Ali, AU - Felehgari,Vahid, Y1 - 2011/09/23/ PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/6/19/medline SP - 553 EP - 9 JF - DNA and cell biology JO - DNA Cell Biol. VL - 31 IS - 4 N2 - The aim of the current study was to examine the influence of interaction between polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C with angiotensin converting enzyme insertion/deletion (ACE I/D) polymorphism on the risk of diabetic nephropathy (DN). In a case control study using polymerase chain reaction (PCR)- and PCR-restriction fragment length polymorphism (RFLP), the presence of three polymorphisms in 140 patients with type 2 diabetes mellitus (T2DM) with nephropathy including patients with micro- and macro-albuminuria and 72 patients with normoalbuminuria from Western Iran were investigated. In the presence of both MTHFR 677 T and ACE D alleles, there was a trend toward increased risk of DN 2.68-fold (p=0.054). The possession of both MTHFR 677 T and ACE D alleles increased the risk of macro-albuminuria four times (p=0.035). The concomitant presence of both MTHFR 1298 C and ACE D alleles increased the risk of macro-albuminuria 7.8-fold (p=0.012). In addition, the risk of progression from micro- to macro-albuminuria in the presence of both alleles tended to be increased (4.1-fold, p=0.09). Our study for the first time demonstrated a synergistic effect between ACE I/D with either MTHFR C677T or A1298C polymorphism on the increased risk of DN among patients with T2DM. We found that MTHFR 1298 C strongly interacts with the ACE D allele and augments the risk of DN in our population. SN - 1557-7430 UR - https://www.unboundmedicine.com/medline/citation/21942443/Interaction_of_MTHFR_1298C_with_ACE_D_allele_augments_the_risk_of_diabetic_nephropathy_in_Western_Iran_ L2 - https://www.liebertpub.com/doi/full/10.1089/dna.2011.1364?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -