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Levonorgestrel releasing-intrauterine system for the treatment of menorrhagia and/or frequent irregular uterine bleeding associated with uterine leiomyoma.
Eur J Contracept Reprod Health Care. 2011 Dec; 16(6):480-7.EJ

Abstract

OBJECTIVE

To evaluate the effectiveness of the levonorgestrel releasing-intrauterine system (LNG-IUS) in the treatment of menorrhagia and/or frequent irregular uterine bleeding in women with uterine myomas.

STUDY DESIGN

Prospective study whereby 102 women with intramural myomas (in a few cases associated with submucous or subserous myomas), suffering from menorrhagia and/or frequent irregular uterine bleeding, were evaluated by means of the Pictorial Blood Assessment Chart (PBAC; Higham score) and ultrasound, three, six and 12 months after insertion of a LNG-IUS.

RESULTS

The PBAC score dropped (from a mean value of 231.7 to 17.6 at 12 months). The duration of menstrual bleeding diminished significantly (p<0.001). Uterine volume decreased from a mean of 145 cm3 to 129 cm3 at 12 months (p=0.01). Changes in the volume of the myomas were not statistically significant (p=0.23). Satisfaction rate was good in 91 cases (89%), fair in four cases (4%), and poor in seven cases (7%). During the one-year period of follow-up, 11 cases of expulsion or removal of the LNG-IUS were recorded.

CONCLUSION

The LNG-IUS is effective in controlling heavy menorrhagia and/or frequent irregular uterine bleeding related to the presence of myomas, but has no significant effect on the size of the tumours.

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Publisher Full Text

Authors+Show Affiliations

Socolov D
Department of Obstetrics and Gynaecology, Gr. T. Popa University of Medicine, and Cuza Voda Maternity University Hospital, Iasi, Romania.
Blidaru I
No affiliation info available
Tamba B
No affiliation info available
Miron N
No affiliation info available
Boiculese L
No affiliation info available
Socolov R
No affiliation info available

MeSH

AdultContraceptive Agents, FemaleDevice RemovalFemaleHumansIntrauterine Device ExpulsionIntrauterine Devices, MedicatedLeiomyomaLevonorgestrelMenorrhagiaMiddle AgedOrgan SizePatient SatisfactionSeverity of Illness IndexTreatment OutcomeTumor BurdenUltrasonographyUterine HemorrhageUterine NeoplasmsUterus

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21942657

Citation

Socolov, Demetra, et al. "Levonorgestrel Releasing-intrauterine System for the Treatment of Menorrhagia And/or Frequent Irregular Uterine Bleeding Associated With Uterine Leiomyoma." The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, vol. 16, no. 6, 2011, pp. 480-7.
Socolov D, Blidaru I, Tamba B, et al. Levonorgestrel releasing-intrauterine system for the treatment of menorrhagia and/or frequent irregular uterine bleeding associated with uterine leiomyoma. Eur J Contracept Reprod Health Care. 2011;16(6):480-7.
Socolov, D., Blidaru, I., Tamba, B., Miron, N., Boiculese, L., & Socolov, R. (2011). Levonorgestrel releasing-intrauterine system for the treatment of menorrhagia and/or frequent irregular uterine bleeding associated with uterine leiomyoma. The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 16(6), 480-7. https://doi.org/10.3109/13625187.2011.614028
Socolov D, et al. Levonorgestrel Releasing-intrauterine System for the Treatment of Menorrhagia And/or Frequent Irregular Uterine Bleeding Associated With Uterine Leiomyoma. Eur J Contracept Reprod Health Care. 2011;16(6):480-7. PubMed PMID: 21942657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levonorgestrel releasing-intrauterine system for the treatment of menorrhagia and/or frequent irregular uterine bleeding associated with uterine leiomyoma. AU - Socolov,Demetra, AU - Blidaru,Iolanda, AU - Tamba,Bogdan, AU - Miron,Nora, AU - Boiculese,Lucian, AU - Socolov,Razvan, Y1 - 2011/09/26/ PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/4/6/medline SP - 480 EP - 7 JF - The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception JO - Eur J Contracept Reprod Health Care VL - 16 IS - 6 N2 - OBJECTIVE: To evaluate the effectiveness of the levonorgestrel releasing-intrauterine system (LNG-IUS) in the treatment of menorrhagia and/or frequent irregular uterine bleeding in women with uterine myomas. STUDY DESIGN: Prospective study whereby 102 women with intramural myomas (in a few cases associated with submucous or subserous myomas), suffering from menorrhagia and/or frequent irregular uterine bleeding, were evaluated by means of the Pictorial Blood Assessment Chart (PBAC; Higham score) and ultrasound, three, six and 12 months after insertion of a LNG-IUS. RESULTS: The PBAC score dropped (from a mean value of 231.7 to 17.6 at 12 months). The duration of menstrual bleeding diminished significantly (p<0.001). Uterine volume decreased from a mean of 145 cm3 to 129 cm3 at 12 months (p=0.01). Changes in the volume of the myomas were not statistically significant (p=0.23). Satisfaction rate was good in 91 cases (89%), fair in four cases (4%), and poor in seven cases (7%). During the one-year period of follow-up, 11 cases of expulsion or removal of the LNG-IUS were recorded. CONCLUSION: The LNG-IUS is effective in controlling heavy menorrhagia and/or frequent irregular uterine bleeding related to the presence of myomas, but has no significant effect on the size of the tumours. SN - 1473-0782 UR - https://www.unboundmedicine.com/medline/citation/21942657/Levonorgestrel_releasing_intrauterine_system_for_the_treatment_of_menorrhagia_and/or_frequent_irregular_uterine_bleeding_associated_with_uterine_leiomyoma_ L2 - https://www.tandfonline.com/doi/full/10.3109/13625187.2011.614028 DB - PRIME DP - Unbound Medicine ER -