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The ATHENA human papillomavirus study: design, methods, and baseline results.
Am J Obstet Gynecol. 2012 Jan; 206(1):46.e1-46.e11.AJ

Abstract

OBJECTIVE

The objective of the study was to describe baseline data from Addressing the Need for Advanced HPV Diagnostics, a prospective, multicenter US cervical cancer screening trial.

STUDY DESIGN

A total of 47,208 women aged 21 years or older undergoing routine screening were enrolled; liquid-based cytology and human papillomavirus (HPV) testing were performed. Women with abnormal cytology underwent colposcopy, as did high-risk HPV (hrHPV)-positive women and a random subset of women negative by both tests aged 25 years or older. Verification bias adjustment was applied; 95% confidence intervals were computed by the bootstrap method.

RESULTS

The prevalence of cytologic abnormalities was 7.1%. hrHPV, HPV 16, and HPV 18 were detected using the cobas HPV Test in 12.6%, 2.8%, and 1.0% of women, respectively. Both cytologic abnormalities and hrHPV positivity declined with increasing age. The adjusted prevalence of cervical intraepithelial neoplasia grade 2 (CIN2) or greater in women aged 25-34 years was 2.3%, decreasing to 1.5% among older women.

CONCLUSION

The Addressing the Need for Advanced HPV Diagnostics study provides important estimates of the prevalence of cytologic abnormalities, hrHPV positivity, and CIN2 or greater in a US screening population.

Authors+Show Affiliations

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21944226

Citation

Wright, Thomas C., et al. "The ATHENA Human Papillomavirus Study: Design, Methods, and Baseline Results." American Journal of Obstetrics and Gynecology, vol. 206, no. 1, 2012, pp. 46.e1-46.e11.
Wright TC, Stoler MH, Behrens CM, et al. The ATHENA human papillomavirus study: design, methods, and baseline results. Am J Obstet Gynecol. 2012;206(1):46.e1-46.e11.
Wright, T. C., Stoler, M. H., Behrens, C. M., Apple, R., Derion, T., & Wright, T. L. (2012). The ATHENA human papillomavirus study: design, methods, and baseline results. American Journal of Obstetrics and Gynecology, 206(1), e1-e11. https://doi.org/10.1016/j.ajog.2011.07.024
Wright TC, et al. The ATHENA Human Papillomavirus Study: Design, Methods, and Baseline Results. Am J Obstet Gynecol. 2012;206(1):46.e1-46.e11. PubMed PMID: 21944226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ATHENA human papillomavirus study: design, methods, and baseline results. AU - Wright,Thomas C,Jr AU - Stoler,Mark H, AU - Behrens,Catherine M, AU - Apple,Raymond, AU - Derion,Toniann, AU - Wright,Teresa L, Y1 - 2011/07/22/ PY - 2011/04/12/received PY - 2011/06/14/revised PY - 2011/07/13/accepted PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/2/24/medline SP - 46.e1 EP - 46.e11 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 206 IS - 1 N2 - OBJECTIVE: The objective of the study was to describe baseline data from Addressing the Need for Advanced HPV Diagnostics, a prospective, multicenter US cervical cancer screening trial. STUDY DESIGN: A total of 47,208 women aged 21 years or older undergoing routine screening were enrolled; liquid-based cytology and human papillomavirus (HPV) testing were performed. Women with abnormal cytology underwent colposcopy, as did high-risk HPV (hrHPV)-positive women and a random subset of women negative by both tests aged 25 years or older. Verification bias adjustment was applied; 95% confidence intervals were computed by the bootstrap method. RESULTS: The prevalence of cytologic abnormalities was 7.1%. hrHPV, HPV 16, and HPV 18 were detected using the cobas HPV Test in 12.6%, 2.8%, and 1.0% of women, respectively. Both cytologic abnormalities and hrHPV positivity declined with increasing age. The adjusted prevalence of cervical intraepithelial neoplasia grade 2 (CIN2) or greater in women aged 25-34 years was 2.3%, decreasing to 1.5% among older women. CONCLUSION: The Addressing the Need for Advanced HPV Diagnostics study provides important estimates of the prevalence of cytologic abnormalities, hrHPV positivity, and CIN2 or greater in a US screening population. SN - 1097-6868 UR - https://www.unboundmedicine.com/medline/citation/21944226/The_ATHENA_human_papillomavirus_study:_design_methods_and_baseline_results_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9378(11)00940-9 DB - PRIME DP - Unbound Medicine ER -