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Effect of low fat-high carbohydrate diets in hypertensive patients with non-insulin-dependent diabetes mellitus.
Am J Hypertens 1990; 3(7):527-32AJ

Abstract

Effects of variations in dietary fat and carbohydrate content on various aspects of glucose, insulin, and lipoprotein metabolism were evaluated in 11 patients with hypertension, who also had non-insulin-dependent diabetes mellitus (NIDDM). All of these patients were being treated with sulfonylureas, thiazides, and beta-adrenergic receptor antagonists. The comparison diets contained either 40 or 60% of total calories as carbohydrate, with reciprocal changes in fat content from 40 to 20%. The diets were consumed in a random order for 15 days in a crossover experimental design. The ratio of polyunsaturated to saturated fat and total cholesterol intake were held constant in the two diets. Plasma glucose and insulin concentrations were significantly (P less than .001) elevated throughout the day when patients consumed the 60% carbohydrate diet. Fasting plasma total and very-low-density lipoprotein (VLDL) and triglyceride (TG) concentrations increased by 30% (P less than .001) after 15 days on the 60% carbohydrate diet. Total plasma cholesterol concentrations were similar on both diets, as were low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations.

Authors+Show Affiliations

Department of Medicine, Tri-Service General Hospital, Taipei, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2194509

Citation

Fuh, M M., et al. "Effect of Low Fat-high Carbohydrate Diets in Hypertensive Patients With Non-insulin-dependent Diabetes Mellitus." American Journal of Hypertension, vol. 3, no. 7, 1990, pp. 527-32.
Fuh MM, Lee MM, Jeng CY, et al. Effect of low fat-high carbohydrate diets in hypertensive patients with non-insulin-dependent diabetes mellitus. Am J Hypertens. 1990;3(7):527-32.
Fuh, M. M., Lee, M. M., Jeng, C. Y., Ma, F., Chen, Y. D., & Reaven, G. M. (1990). Effect of low fat-high carbohydrate diets in hypertensive patients with non-insulin-dependent diabetes mellitus. American Journal of Hypertension, 3(7), pp. 527-32.
Fuh MM, et al. Effect of Low Fat-high Carbohydrate Diets in Hypertensive Patients With Non-insulin-dependent Diabetes Mellitus. Am J Hypertens. 1990;3(7):527-32. PubMed PMID: 2194509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of low fat-high carbohydrate diets in hypertensive patients with non-insulin-dependent diabetes mellitus. AU - Fuh,M M, AU - Lee,M M, AU - Jeng,C Y, AU - Ma,F, AU - Chen,Y D, AU - Reaven,G M, PY - 1990/7/1/pubmed PY - 1990/7/1/medline PY - 1990/7/1/entrez SP - 527 EP - 32 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 3 IS - 7 N2 - Effects of variations in dietary fat and carbohydrate content on various aspects of glucose, insulin, and lipoprotein metabolism were evaluated in 11 patients with hypertension, who also had non-insulin-dependent diabetes mellitus (NIDDM). All of these patients were being treated with sulfonylureas, thiazides, and beta-adrenergic receptor antagonists. The comparison diets contained either 40 or 60% of total calories as carbohydrate, with reciprocal changes in fat content from 40 to 20%. The diets were consumed in a random order for 15 days in a crossover experimental design. The ratio of polyunsaturated to saturated fat and total cholesterol intake were held constant in the two diets. Plasma glucose and insulin concentrations were significantly (P less than .001) elevated throughout the day when patients consumed the 60% carbohydrate diet. Fasting plasma total and very-low-density lipoprotein (VLDL) and triglyceride (TG) concentrations increased by 30% (P less than .001) after 15 days on the 60% carbohydrate diet. Total plasma cholesterol concentrations were similar on both diets, as were low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol concentrations. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/2194509/Effect_of_low_fat_high_carbohydrate_diets_in_hypertensive_patients_with_non_insulin_dependent_diabetes_mellitus_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1093/ajh/3.7.527 DB - PRIME DP - Unbound Medicine ER -