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Age-related changes in the three-way correlation between anterior hippocampus volume, whole-brain patterns of encoding activity and subsequent context retrieval.
Brain Res. 2011 Oct 28; 1420:68-79.BR

Abstract

Age-related declines in memory for context have been linked to volume loss in the hippocampal head (HH) with age. However, it remains unclear how this volumetric decline correlates with age-related changes in whole-brain activity during context encoding, and subsequent context retrieval. In the current study we examine this. We collected functional magnetic resonance imaging data in young and older adults during the encoding of item, spatial context and temporal context. HH volume and subsequent retrieval performance was measured in all participants. In young adults only there was a positive three-way correlation between larger HH volumes, better memory retrieval, and increased activity in right hippocampus, right ventrolateral prefrontal cortex (VLPFC) and midline brain regions during episodic encoding. In contrast, older adults exhibited a positive three-way association between HH volume, generalized activity in bilateral hippocampus and dorsolateral PFC across all encoding tasks, and subsequent spatial context retrieval. Young adults also engaged this network, but only during the most difficult temporal context encoding task and activity in this network correlated with subsequent temporal context retrieval. We conclude that age-related volumetric reductions in HH disrupted the structure-function association between the hippocampus and activity in the first general encoding network recruited by young adults. Instead, older adults recruited those brain regions young adults only engaged for the most difficult temporal task, at lower difficulty levels. This altered pattern of association correlated with spatial context retrieval in older adults, but was not sufficient to maintain context memory abilities overall.

Authors+Show Affiliations

Department of Neuroscience, McGill Univ., Montreal, QC, Canada H3A 2T5.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21945346

Citation

Maillet, David, and M Natasha Rajah. "Age-related Changes in the Three-way Correlation Between Anterior Hippocampus Volume, Whole-brain Patterns of Encoding Activity and Subsequent Context Retrieval." Brain Research, vol. 1420, 2011, pp. 68-79.
Maillet D, Rajah MN. Age-related changes in the three-way correlation between anterior hippocampus volume, whole-brain patterns of encoding activity and subsequent context retrieval. Brain Res. 2011;1420:68-79.
Maillet, D., & Rajah, M. N. (2011). Age-related changes in the three-way correlation between anterior hippocampus volume, whole-brain patterns of encoding activity and subsequent context retrieval. Brain Research, 1420, 68-79. https://doi.org/10.1016/j.brainres.2011.08.071
Maillet D, Rajah MN. Age-related Changes in the Three-way Correlation Between Anterior Hippocampus Volume, Whole-brain Patterns of Encoding Activity and Subsequent Context Retrieval. Brain Res. 2011 Oct 28;1420:68-79. PubMed PMID: 21945346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in the three-way correlation between anterior hippocampus volume, whole-brain patterns of encoding activity and subsequent context retrieval. AU - Maillet,David, AU - Rajah,M Natasha, Y1 - 2011/09/05/ PY - 2011/06/30/received PY - 2011/08/12/revised PY - 2011/08/30/accepted PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/2/18/medline SP - 68 EP - 79 JF - Brain research JO - Brain Res. VL - 1420 N2 - Age-related declines in memory for context have been linked to volume loss in the hippocampal head (HH) with age. However, it remains unclear how this volumetric decline correlates with age-related changes in whole-brain activity during context encoding, and subsequent context retrieval. In the current study we examine this. We collected functional magnetic resonance imaging data in young and older adults during the encoding of item, spatial context and temporal context. HH volume and subsequent retrieval performance was measured in all participants. In young adults only there was a positive three-way correlation between larger HH volumes, better memory retrieval, and increased activity in right hippocampus, right ventrolateral prefrontal cortex (VLPFC) and midline brain regions during episodic encoding. In contrast, older adults exhibited a positive three-way association between HH volume, generalized activity in bilateral hippocampus and dorsolateral PFC across all encoding tasks, and subsequent spatial context retrieval. Young adults also engaged this network, but only during the most difficult temporal context encoding task and activity in this network correlated with subsequent temporal context retrieval. We conclude that age-related volumetric reductions in HH disrupted the structure-function association between the hippocampus and activity in the first general encoding network recruited by young adults. Instead, older adults recruited those brain regions young adults only engaged for the most difficult temporal task, at lower difficulty levels. This altered pattern of association correlated with spatial context retrieval in older adults, but was not sufficient to maintain context memory abilities overall. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/21945346/Age_related_changes_in_the_three_way_correlation_between_anterior_hippocampus_volume_whole_brain_patterns_of_encoding_activity_and_subsequent_context_retrieval_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(11)01649-0 DB - PRIME DP - Unbound Medicine ER -