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Effects of neuropeptide FF system on CB₁ and CB₂ receptors mediated antinociception in mice.
Neuropharmacology. 2012 Feb; 62(2):855-64.N

Abstract

It has been demonstrated that opioid and cannabinoid receptor systems can produce similar signal transduction and behavioural effects. Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in control of pain and analgesia through interactions with the opioid system. We were interested in whether the central and peripheral antinociception of cannabinoids could be influenced by supraspinal NPFF system. The present study examined the effects of NPFF and related peptides on the antinociceptive activities induced by the non-selective cannabinoid receptors agonist WIN55,212-2, given by supraspinal and intraplantar routes. In mice, the central and peripheral antinociception of WIN55,212-2 are mediated by cannabinoid CB(1) and CB(2) receptors, respectively. Interestingly, central administration of NPFF significantly reduced central and peripheral analgesia of cannabinoids in dose-dependent manners. In contrast, dNPA and NPVF (i.c.v.), two highly selective agonists for NPFF(2) and NPFF(1) receptors, dose-dependently augmented the antinociception caused by intracerebroventricular and intraplantar injection of WIN55,212-2. Additionally, pretreatment with the NPFF receptors selective antagonist RF9 (i.c.v.) markedly reduced the cannabinoid-modulating activities of NPFF and related peptides in nociceptive assays. These data provide the first evidence for a functional interaction between NPFF and cannabinoid systems, indicating that activation of central NPFF receptors interferes with cannabinoid-mediated central and peripheral antinociception. Intriguingly, the present work may pave the way for a new strategy of using combination treatment of cannabinoid and NPFF agonists for pain management. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.

Authors+Show Affiliations

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Physiology & Psychology, School of Basic Medical Sciences, Lanzhou University, 199 Donggang West Road, Lanzhou 730000, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21945715

Citation

Fang, Quan, et al. "Effects of Neuropeptide FF System On CB₁ and CB₂ Receptors Mediated Antinociception in Mice." Neuropharmacology, vol. 62, no. 2, 2012, pp. 855-64.
Fang Q, Han ZL, Li N, et al. Effects of neuropeptide FF system on CB₁ and CB₂ receptors mediated antinociception in mice. Neuropharmacology. 2012;62(2):855-64.
Fang, Q., Han, Z. L., Li, N., Wang, Z. L., He, N., & Wang, R. (2012). Effects of neuropeptide FF system on CB₁ and CB₂ receptors mediated antinociception in mice. Neuropharmacology, 62(2), 855-64. https://doi.org/10.1016/j.neuropharm.2011.09.013
Fang Q, et al. Effects of Neuropeptide FF System On CB₁ and CB₂ Receptors Mediated Antinociception in Mice. Neuropharmacology. 2012;62(2):855-64. PubMed PMID: 21945715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of neuropeptide FF system on CB₁ and CB₂ receptors mediated antinociception in mice. AU - Fang,Quan, AU - Han,Zheng-Lan, AU - Li,Ning, AU - Wang,Zi-Long, AU - He,Ning, AU - Wang,Rui, Y1 - 2011/09/19/ PY - 2011/06/21/received PY - 2011/09/04/revised PY - 2011/09/13/accepted PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/7/28/medline SP - 855 EP - 64 JF - Neuropharmacology JO - Neuropharmacology VL - 62 IS - 2 N2 - It has been demonstrated that opioid and cannabinoid receptor systems can produce similar signal transduction and behavioural effects. Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in control of pain and analgesia through interactions with the opioid system. We were interested in whether the central and peripheral antinociception of cannabinoids could be influenced by supraspinal NPFF system. The present study examined the effects of NPFF and related peptides on the antinociceptive activities induced by the non-selective cannabinoid receptors agonist WIN55,212-2, given by supraspinal and intraplantar routes. In mice, the central and peripheral antinociception of WIN55,212-2 are mediated by cannabinoid CB(1) and CB(2) receptors, respectively. Interestingly, central administration of NPFF significantly reduced central and peripheral analgesia of cannabinoids in dose-dependent manners. In contrast, dNPA and NPVF (i.c.v.), two highly selective agonists for NPFF(2) and NPFF(1) receptors, dose-dependently augmented the antinociception caused by intracerebroventricular and intraplantar injection of WIN55,212-2. Additionally, pretreatment with the NPFF receptors selective antagonist RF9 (i.c.v.) markedly reduced the cannabinoid-modulating activities of NPFF and related peptides in nociceptive assays. These data provide the first evidence for a functional interaction between NPFF and cannabinoid systems, indicating that activation of central NPFF receptors interferes with cannabinoid-mediated central and peripheral antinociception. Intriguingly, the present work may pave the way for a new strategy of using combination treatment of cannabinoid and NPFF agonists for pain management. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/21945715/Effects_of_neuropeptide_FF_system_on_CB₁_and_CB₂_receptors_mediated_antinociception_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(11)00408-4 DB - PRIME DP - Unbound Medicine ER -