Tags

Type your tag names separated by a space and hit enter

Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system.
Acta Pharm. 2011 Sep 01; 61(3):343-51.AP

Abstract

The study was carried out to establish the effectiveness of a mixed film composed of ethylcellulose/Eudragit S100 for colonic delivery of 5-flourouracil (5-FU). Tablets cores containing 5-FU were prepared by direct compression method by coating at different levels (2-9%, m/m) with a non-aqueous solution containing ethylcellulose/Eudragit S100. Coated tablets were studied for the in vitro release of 5-FU and the samples were analyzed spectrophotometrically at 266 nm. Drug release from coated systems depended on the thickness of the mixed film and the composition of the core. Channel formation was initiated in the coat by dissolution of the Eudragit S100 fraction at higher pH in the colonic region. The release was found to be higher in tablets containing Avicel as filler owing to its wicking action compared to that from lactose containing cores. Furthermore, batches containing superdisintegrant (1%, m/m Cross-PVP) along with Avicel in the core released approximately 81.1% drug during the colonic transit time. Kinetic studies indicated that all the formulations followed first-order release kinetics. The developed delivery system will expectedly deliver the drug to the colon.

Authors+Show Affiliations

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21945913

Citation

Kumar, Ruchita V., and Vivek Ranjan Sinha. "Tailoring of Drug Delivery of 5-fluorouracil to the Colon Via a Mixed Film Coated Unit System." Acta Pharmaceutica (Zagreb, Croatia), vol. 61, no. 3, 2011, pp. 343-51.
Kumar RV, Sinha VR. Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. Acta Pharm. 2011;61(3):343-51.
Kumar, R. V., & Sinha, V. R. (2011). Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. Acta Pharmaceutica (Zagreb, Croatia), 61(3), 343-51. https://doi.org/10.2478/v10007-011-0023-5
Kumar RV, Sinha VR. Tailoring of Drug Delivery of 5-fluorouracil to the Colon Via a Mixed Film Coated Unit System. Acta Pharm. 2011 Sep 1;61(3):343-51. PubMed PMID: 21945913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tailoring of drug delivery of 5-fluorouracil to the colon via a mixed film coated unit system. AU - Kumar,Ruchita V, AU - Sinha,Vivek Ranjan, PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/3/20/medline SP - 343 EP - 51 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 61 IS - 3 N2 - The study was carried out to establish the effectiveness of a mixed film composed of ethylcellulose/Eudragit S100 for colonic delivery of 5-flourouracil (5-FU). Tablets cores containing 5-FU were prepared by direct compression method by coating at different levels (2-9%, m/m) with a non-aqueous solution containing ethylcellulose/Eudragit S100. Coated tablets were studied for the in vitro release of 5-FU and the samples were analyzed spectrophotometrically at 266 nm. Drug release from coated systems depended on the thickness of the mixed film and the composition of the core. Channel formation was initiated in the coat by dissolution of the Eudragit S100 fraction at higher pH in the colonic region. The release was found to be higher in tablets containing Avicel as filler owing to its wicking action compared to that from lactose containing cores. Furthermore, batches containing superdisintegrant (1%, m/m Cross-PVP) along with Avicel in the core released approximately 81.1% drug during the colonic transit time. Kinetic studies indicated that all the formulations followed first-order release kinetics. The developed delivery system will expectedly deliver the drug to the colon. SN - 1846-9558 UR - https://www.unboundmedicine.com/medline/citation/21945913/Tailoring_of_drug_delivery_of_5_fluorouracil_to_the_colon_via_a_mixed_film_coated_unit_system_ L2 - https://www.degruyter.com/doi/10.2478/v10007-011-0023-5 DB - PRIME DP - Unbound Medicine ER -