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Study of the critical points and the role of the pores and viscosity in carbamazepine hydrophilic matrix tablets.
Eur J Pharm Biopharm. 2012 Jan; 80(1):136-42.EJ

Abstract

Percolation theory has been applied to estimate the Hypromellose (HPMC) percolation thresholds and the influence of the polymer viscosity and the initial porosity on these thresholds in carbamazepine multicomponent matrix formulations. Different batches containing two viscosity grades of HPMC as hydrophilic matrix forming polymer, MCC and lactose as fillers, and a lubricant mixture have been manufactured varying the compression pressure in order to obtain matrices with three levels of initial porosity. The results suggested the existence of an excipient percolation threshold between 13 and 15% v/v of HPMC for the different batches prepared. It has been found that the percolation threshold for this polymer is independent on the formulation factors studied in this paper: polymer viscosity and initial porosity of the matrices.

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Authors+Show Affiliations

Aguilar-de-Leyva A
Department of Pharmacy and Pharmaceutical Technology, University of Seville, Seville, Spain.
Cifuentes C
No affiliation info available
Rajabi-Siahboomi AR
No affiliation info available
Caraballo I
No affiliation info available

MeSH

CarbamazepineChemistry, PharmaceuticalDelayed-Action PreparationsExcipientsHydrophobic and Hydrophilic InteractionsHypromellose DerivativesKineticsLactoseMethylcelluloseParticle SizePolymersPorosityTabletsViscosity

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21946473

Citation

Aguilar-de-Leyva, Angela, et al. "Study of the Critical Points and the Role of the Pores and Viscosity in Carbamazepine Hydrophilic Matrix Tablets." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 80, no. 1, 2012, pp. 136-42.
Aguilar-de-Leyva A, Cifuentes C, Rajabi-Siahboomi AR, et al. Study of the critical points and the role of the pores and viscosity in carbamazepine hydrophilic matrix tablets. Eur J Pharm Biopharm. 2012;80(1):136-42.
Aguilar-de-Leyva, A., Cifuentes, C., Rajabi-Siahboomi, A. R., & Caraballo, I. (2012). Study of the critical points and the role of the pores and viscosity in carbamazepine hydrophilic matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 80(1), 136-42. https://doi.org/10.1016/j.ejpb.2011.09.007
Aguilar-de-Leyva A, et al. Study of the Critical Points and the Role of the Pores and Viscosity in Carbamazepine Hydrophilic Matrix Tablets. Eur J Pharm Biopharm. 2012;80(1):136-42. PubMed PMID: 21946473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of the critical points and the role of the pores and viscosity in carbamazepine hydrophilic matrix tablets. AU - Aguilar-de-Leyva,Angela, AU - Cifuentes,Celia, AU - Rajabi-Siahboomi,Ali R, AU - Caraballo,Isidoro, Y1 - 2011/09/17/ PY - 2011/05/19/received PY - 2011/08/23/revised PY - 2011/09/12/accepted PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/7/3/medline SP - 136 EP - 42 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 80 IS - 1 N2 - Percolation theory has been applied to estimate the Hypromellose (HPMC) percolation thresholds and the influence of the polymer viscosity and the initial porosity on these thresholds in carbamazepine multicomponent matrix formulations. Different batches containing two viscosity grades of HPMC as hydrophilic matrix forming polymer, MCC and lactose as fillers, and a lubricant mixture have been manufactured varying the compression pressure in order to obtain matrices with three levels of initial porosity. The results suggested the existence of an excipient percolation threshold between 13 and 15% v/v of HPMC for the different batches prepared. It has been found that the percolation threshold for this polymer is independent on the formulation factors studied in this paper: polymer viscosity and initial porosity of the matrices. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/21946473/Study_of_the_critical_points_and_the_role_of_the_pores_and_viscosity_in_carbamazepine_hydrophilic_matrix_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(11)00268-2 DB - PRIME DP - Unbound Medicine ER -