Tags

Type your tag names separated by a space and hit enter

Could the level of serum albumin be a method for assessing malnutrition in hemodialysis patients?
Nutr Clin Pract. 2011 Oct; 26(5):607-13.NC

Abstract

BACKGROUND

Traditionally, serum albumin concentration has been used for assessing the nutrition status of hemodialysis patients despite evidence that the level is also affected by inflammation and many other underlying disorders frequently present in these individuals. The authors evaluated albumin as a nutrition parameter, comparing it with more specific anthropometric parameters.

METHODS

The study included a cohort of 271 patients. The analysis involved data obtained after patients entered the study (1994-2004). Anthropometric measurements included skinfolds, mid-arm circumference, mid-arm muscle circumference, percentage of body fat, body mass index, body height, and dry weight. Kt/V and normalized protein catabolic rate were also determined and laboratory analyses undertaken.

RESULTS

Serum albumin was only weakly correlated with mid-arm circumference (r = 0.12), mid-arm muscle circumference (r = 0.15), and fat-free mass (r = 0.12). Common factor analysis of nutrition parameters uncovered latent variables, but serum albumin was not associated strongly with them. The sensitivity of albumin in detecting malnutrition was 24%, with a specificity of 88% and a predictive value of 74%. Graphic analysis showed disagreement in albumin levels with percentage of body fat and mid-arm muscle circumference.

CONCLUSION

Serum albumin determination was shown to be a test with low sensitivity and specificity for evaluating malnutrition in hemodialysis patients. The values correlated weakly and showed graphic disagreement with anthropometric parameters. Therefore, methods that measure percentage of body fat and muscle mass should be used together or instead of serum albumin level for assessing the nutrition status of hemodialysis patients.

Authors+Show Affiliations

Clinic of Nephrology, Clinical Center of Serbia, Beograd, Serbia. milanst@eunet.rsNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21947644

Citation

Stosovic, Milan D., et al. "Could the Level of Serum Albumin Be a Method for Assessing Malnutrition in Hemodialysis Patients?" Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 26, no. 5, 2011, pp. 607-13.
Stosovic MD, Naumovic RT, Stanojevic MLj, et al. Could the level of serum albumin be a method for assessing malnutrition in hemodialysis patients? Nutr Clin Pract. 2011;26(5):607-13.
Stosovic, M. D., Naumovic, R. T., Stanojevic, M. L. j., Simic-Ogrizovic, S. P., Jovanovic, D. B., & Djukanovic, L. D. (2011). Could the level of serum albumin be a method for assessing malnutrition in hemodialysis patients? Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 26(5), 607-13. https://doi.org/10.1177/0884533611419665
Stosovic MD, et al. Could the Level of Serum Albumin Be a Method for Assessing Malnutrition in Hemodialysis Patients. Nutr Clin Pract. 2011;26(5):607-13. PubMed PMID: 21947644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Could the level of serum albumin be a method for assessing malnutrition in hemodialysis patients? AU - Stosovic,Milan D, AU - Naumovic,Radomir T, AU - Stanojevic,Mirjana Lj, AU - Simic-Ogrizovic,Sanja P, AU - Jovanovic,Dijana B, AU - Djukanovic,Ljubica D, PY - 2011/9/28/entrez PY - 2011/9/29/pubmed PY - 2012/3/28/medline SP - 607 EP - 13 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 26 IS - 5 N2 - BACKGROUND: Traditionally, serum albumin concentration has been used for assessing the nutrition status of hemodialysis patients despite evidence that the level is also affected by inflammation and many other underlying disorders frequently present in these individuals. The authors evaluated albumin as a nutrition parameter, comparing it with more specific anthropometric parameters. METHODS: The study included a cohort of 271 patients. The analysis involved data obtained after patients entered the study (1994-2004). Anthropometric measurements included skinfolds, mid-arm circumference, mid-arm muscle circumference, percentage of body fat, body mass index, body height, and dry weight. Kt/V and normalized protein catabolic rate were also determined and laboratory analyses undertaken. RESULTS: Serum albumin was only weakly correlated with mid-arm circumference (r = 0.12), mid-arm muscle circumference (r = 0.15), and fat-free mass (r = 0.12). Common factor analysis of nutrition parameters uncovered latent variables, but serum albumin was not associated strongly with them. The sensitivity of albumin in detecting malnutrition was 24%, with a specificity of 88% and a predictive value of 74%. Graphic analysis showed disagreement in albumin levels with percentage of body fat and mid-arm muscle circumference. CONCLUSION: Serum albumin determination was shown to be a test with low sensitivity and specificity for evaluating malnutrition in hemodialysis patients. The values correlated weakly and showed graphic disagreement with anthropometric parameters. Therefore, methods that measure percentage of body fat and muscle mass should be used together or instead of serum albumin level for assessing the nutrition status of hemodialysis patients. SN - 1941-2452 UR - https://www.unboundmedicine.com/medline/citation/21947644/Could_the_level_of_serum_albumin_be_a_method_for_assessing_malnutrition_in_hemodialysis_patients L2 - https://doi.org/10.1177/0884533611419665 DB - PRIME DP - Unbound Medicine ER -